Re: [CLL] CLL HSCs - implications?

[Guest guest]

At 04:41 PM 8/16/2011, Al Janski wrote:

>What are other implications of the existence of

>CLL HSCs? For example, what roles might they

>play in recurrence of CLL disease after remissions?

Today, Dr. Hamblin posted comments related to

this subject, focusing on implications for

understanding the etiology of CLL, at:

http://mutated-unmuated.blogspot.com/2011/09/cll-and-leukemic-stem-cells.html

Al Janski

REFERENCES:

PRESS RELEASE:

Stem Cells Central to Pathogenesis of Mature Lymphoid Tumors

http://www.sciencedaily.com/releases/2011/08/110815121521.htm

ORIGINAL RESEARCH PAPER:

" Self-Renewing Hematopoietic Stem Cell Is the

Primary Target in Pathogenesis of Human Chronic

Lymphocytic Leukemia " ; Y. Kikushige et al.;

Cancer Cell 20, 246–259, August 16, 2011

http://www.cell.com/cancer-cell/retrieve/pii/S1535610811002595I

COMMENTARY:

" Surprise! HSC Are Aberrant in Chronic

Lymphocytic Leukemia " ; Ash A. Alizadeh and

Ravindra Majeti; Cancer Cell 20, August 16, 2011 135-136

http://www.sciencedirect.com/science/article/pii/S1535610811002698

SNIP......

" Nearly all current therapies for CLL, including

rituximab, target the mature B cell leukemic

population; however, it may be that therapies

effective at targeting these CLL cells will not

affect the preleukemic HSC. Thus, curative

strategies may need to target not only the

frankly leukemic cells, but also the preleukemic

HSC. How to preferentially target these

preleukemic HSC, as compared to residual normal

HSC, represents a major challenge that will

depend on investigations into the mechanisms that

give rise to these aberrant cells. "