Eating affects previous fat eaten uptake

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Hi All,

Eating a meal apparently affects the uptake of fat that was previously eaten.

The pdf is corrupted for the below.

Their BMI was an average of 26.6 and they were 62 years old on average.

The areas under the curves for the times 0-27 minutes and 270-600 minutes

were:

TAG, 374±66 and 563±116. For Apo B-48, they were: 254±52 and 376±87. for RE,

they

were: 120±36 and 53±66.

Meal ingestion provokes entry of lipoproteins containing fat from the

previous

meal: possible metabolic implications

K. D. R. R. Silva, J. W. , C. M. , et al.

European Journal of Nutrition ISSN: 1436-6207 (Paper) 1436-6215 (Online) Issue:

Online First 05 November, 2004

Summary

Background Prolonged and exaggerated postprandial plasma triacylglycerol (TAG)

concentrations are considered as an independent risk factor for coronary artery

disease. Western populations eat many meals at regular intervals, and can be in

a

postprandial state for at least 17h of a 24h period. After consuming 2 meals an

early plasma TAG peak has been observed after the second meal, the origin of

which

is unclear.

... Methods Postprandial plasma lipaemic responses of 17 healthy

postmenopausal

women were studied by giving a test breakfast followed by a lunch. Watermiscible

retinyl palmitate (RP) was added to the breakfast, but not the lunch test meal.

Plasma TAG, retinyl esters (RE) and apo B–48 were determined for a 10h period

following breakfast.

Results In response to the test meals, RE, apo B–48 and TAG showed multiple

peaks.

Despite omission of RP from the lunch, RE showed an early peak response after

ingestion of lunch in 15 of 17 subjects. The peak response after lunch of all

three

markers appeared significantly earlier compared with their respective peak

responses

after the breakfast (P < 0.0001). The area of RE response after lunch was

significantly correlated with the RE lipaemic response to the breakfast (r =

0.67; P

< 0.004) and to the fasting TAG concentration (r = 0.48; P < 0.05).

Conclusions Since the lunch did not contain RP, the distinctive second influx

of

RE after lunch was believed to have originated from the breakfast. This,

together

with the fact that all three markers showed an earlier response to the lunch

than

the breakfast, supports the view that ingestion of a second meal provokes entry

of

fat from the previous meal, from an as yet unidentified site (gut, enterocytes,

lymph). The results indicate that the degree of TAG storage from previous meals

might be a function of TAG tolerance and provide a possible site of regulation

of

the entry of fat into the systemic circulation.

Al Pater, PhD; email: old542000@...

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