Leptin Levels Significantly Higher in CLL Patients; Correlated with CD38

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Exp Oncol. 2006 Sep;28(3):241-4.

Leptin and resistin levels in serum of patients with hematologic

malignancies: correlation with clinical characteristics.

Pamuk GE, Demir M, Harmandar F, Yesil Y, Turgut B, Vural O.

Department of Hematology, Trakya University Medical Faculty, Edirne,

Turkey. gepamuk@....

AIM: To evaluate leptin and resistin levels in patients with various

hematologic malignancies.

METHODS: We included 21 patients with lymphoma, 14 with multiple

myeloma (MM), 14 with acute leukemia, 13 with chronic lymphocytic

leukemia (CLL), and 25 healthy control subjects into our study. The

subjects' body mass indexes (BMI) were calculated; hematological and

acute phase response parameters, serum lipid were determined; serum

leptin and resistin levels were determined by ELISA.

RESULTS: Serum leptin level was significantly increased in CLL and

MM groups when compared to the control group (p less, similar 0.01).

Resistin level was significantly higher in lymphoma patients than in

CLL, acute leukemia and control groups (p less, similar 0.01). In

the control group, leptin level was negatively correlated with

hemoglobin level (r = -0.44, p = 0.047); and in all patients with

hematologic malignancies, leptin level was correlated with BMI (r =

0.32, p = 0.02). Leptin in lymphoma subjects correlated with

hemoglobin level (r = 0.64, p = 0.005), resistin level correlated

with the platelet count in patients with hematologic malignancies (r

= 0.26, p = 0.044).

In addition, leptin level had negative correlations with

international prognostic score (IPS) in Hodgkin lymphoma (r = -0.9,

p = 0.002) and with international prognostic index (IPI) in non-

Hodgkin lymphoma (r = -0.77, p = 0.03). In CLL patients, leptin

level had a correlation with the poor prognostic marker - CD38 level

(r = 0.68, p = 0.03).

CONCLUSION: We found higher leptin levels in MM and CLL patients,

and higher resistin levels in lymphoma patients: this fact

demonstrates that changes in adipose tissue and metabolism occur in

these disease states.

PMID: 17080020 [PubMed - in process]