A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China.

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A prospective study of 728 cases of non-Hodgkin lymphoma from a single

laboratory in Shanghai, China.

Sherilyn A Gross, Xiongzeng Zhu, Liming Bao, Ryder, Anh Le, Yan Chen, Xiao

Qin Wang, and D Irons

Int J Hematol, July 23, 2008; .

Fudan-Cinpathogen Clinical and Molecular Research Center, Institutes of

Biomedical Sciences, Fudan University, 130 Dong An Road, 200032, Shanghai,

China.

The frequency of subtypes of lymphoid neoplasms was determined in a prospective

series of 831 patients presenting at 29 Shanghai hospitals over a 4-year period.

Diagnosis and classification was established in a single laboratory according to

the 2001 WHO classification system. The frequency of non-Hodgkin lymphoma was

87.6% (n = 728) and Hodgkin lymphoma was 12.4% (n = 103). The most prevalent NHL

subtypes diagnosed using WHO criteria were diffuse large B cell lymphoma

(DLBCL), precursor B lymphoblastic leukemia/lymphoma and chronic lymphocytic

leukemia/small lymphocytic lymphoma (CLL/SLL). Although a low incidence has been

reported in some Asian populations, CLL/SLL was commonly encountered, indicating

that chronic lymphoid neoplasms are not rare in Shanghai. Consistent with

previous reports, our findings indicate a decrease in the frequency of

follicular lymphoma and an increase in T cell neoplasms compared to the West.

Precursor T lymphoblastic leukemia/lymphoma, anaplastic large T cell lymphoma,

aggressive NK cell leukemia, angioimmunoblastic T cell lymphoma and peripheral T

cell lymphoma were prominent subtypes of T cell NHL.

PMID: 18648906