Human Leucocyte Antigen Cw*16 Allele Increased in CLL Patients

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Br J Haematol. 2006 Oct 10; [Epub ahead of print]

Human leucocyte antigen-C in B chronic lymphocytic leukaemia.

* Montes-Ares O, et al

Department of Immunology, Hospital Universitario Virgen de la

Arrixaca, Murcia, Spain.

This study aimed at characterising the distribution of human

leucocyte antigen (HLA)-C alleles in a large group of patients with B

chronic lymphocytic leukaemia from Southeastern Spain.

Ninety-eight adult patients and 194 geographically and ethnically

matched controls were studied. HLA-C was determined by polymerase

chain reaction sequence-specific primers (PCR-SSP) and

PCR-sequence-specific oligonucleotides (SSO) methods.

The HLA-Cw*16 allele frequency was found to be significantly increased

amongst patients compared with controls in our population (27.6% vs.

12.4%, P = 0.0012, Pc = 0.016). HLA-C dimorphism was also analysed but

no association was found.

PMID: 17054674 [PubMed - as supplied by publisher]