Re: Re: CR affect on bones

[Guest guest]

--- Rodney <perspect1111@...> wrote:

>

> Mice live three or four years. Humans live 70 to 100 years. So the

> ratio human/mouse lifespan is roughly 25:1. (Please correct me if I

> have this wrong). So fourteen weeks of age in mice is the equivalent

> of about 6.7 years in humans. This is well after weaning, but before

> puberty and a long time before full growth is attained.

>

> For sure this study may have great relevance to humans put on CR at

> age seven. But I would think it would have little relevance to those

> of us who started CRON after age 20.

>

Hi All,

Mice develop much more quickly than humans for their growth to puberty. Only

about

a month should do it, I seem to recall.

Al Pater, PhD; email: old542000@...

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[Guest guest]

--- Rodney <perspect1111@...> wrote:

>

> Mice live three or four years. Humans live 70 to 100 years. So the

> ratio human/mouse lifespan is roughly 25:1. (Please correct me if I

> have this wrong). So fourteen weeks of age in mice is the equivalent

> of about 6.7 years in humans. This is well after weaning, but before

> puberty and a long time before full growth is attained.

>

> For sure this study may have great relevance to humans put on CR at

> age seven. But I would think it would have little relevance to those

> of us who started CRON after age 20.

>

Hi All,

Mice develop much more quickly than humans for their growth to puberty. Only

about

a month should do it, I seem to recall.

Al Pater, PhD; email: old542000@...

__________________________________

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[Guest guest]

Hi All and Rodney,

Yes, it is so. See the sideways of interest and pdf-available below.

Ann N Y Acad Sci. 2003 May;993:161-7; discussion 195-6.

Mating attenuates aging-associated increase of lipid peroxidation activity in

C57BL/6J mice.

Oxenkrug GF, Requintina PJ.

In the frame of the free-radical hypothesis of aging and literature data on

increased life span of mated animals, we evaluated brain, kidney, and liver

lipid

peroxidation in C57Bl/6J mice of various ages and compared lipid peroxidation

activity in mated and non-mated mice of both genders. An aging-associated

increase

(from 3 to 12 months of age) of lipid peroxidation, as measured by malonaldehyde

and

4-hydroxyalkenals (MDA + HAE) levels, was observed in the liver and kidney, but

not

in the brain. Tissue MDA + HAE levels were lower in 12-month old mated mice

(housed

with animals of opposite gender from three to five months of age) than in

12-month

old non-mated animals. There were no gender differences in the observed effect.

It

is suggested that mating might attenuate the increase of lipid peroxidation

associated with aging.

PMID: 12853310

--- Rodney <perspect1111@...> wrote:

> Hi Al:

>

> So here is the answer: " A healthy, well fed mouse is generally

> considered to have reached its adult size by 12 weeks, although

> internally they may still do a little growing for a couple more

> weeks, but it will not be noticeable " .

>

> So perhaps that is why the study started with 14-weeks old mice.

>

> Hmmmmm. So that makes those data in that study possibly very

> relevant to us. Thank you for correcting me on that.

>

> Rodney.

>

>

> > > >

> > > > Mice live three or four years. Humans live 70 to 100 years.

> So

> > the

> > > > ratio human/mouse lifespan is roughly 25:1. (Please correct me

> > if I

> > > > have this wrong). So fourteen weeks of age in mice is the

> > equivalent

> > > > of about 6.7 years in humans. This is well after weaning, but

> > before

> > > > puberty and a long time before full growth is attained.

> > > >

> > > > For sure this study may have great relevance to humans put on

> CR

> > at

> > > > age seven. But I would think it would have little relevance to

> > those

> > > > of us who started CRON after age 20.

> > > >

> > >

> > > Hi All,

> > >

> > > Mice develop much more quickly than humans for their growth to

> > puberty. Only about

> > > a month should do it, I seem to recall.

> > >

> > > Al Pater, PhD; email: old542000@y...

> > >

> > >

> > >

> > > __________________________________

> > > Mobile

> > > Take with you! Check email on your mobile phone.

> > > http://mobile./learn/mail

>

>

>

Al Pater, PhD; email: old542000@...

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