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The Efficacy of HGAL and LMO2 in the Separation of Lymphomas Derived From Small B Cells in Nodal and Extranodal Sites, Including the Bone Marrow

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BlankThe Efficacy of HGAL and LMO2 in the Separation of Lymphomas Derived From

Small B Cells in Nodal and Extranodal Sites, Including the Bone Marrow

1.. Sheren F. Younes, MD1,

2.. H. Beck, MD1,

3.. S. Ohgami, MD, PhD1,

4.. Izidore S. Lossos, MD2,

5.. Levy, MD3,

6.. A. Warnke, MD1 and

7.. Yasodha Natkunam, MD, PhD1

+ Author Affiliations

1.. 1From the Departments of Pathology and

2.. 3Medicine, Division of Oncology, Stanford University School of Medicine,

Stanford, CA; and

3.. 2Medicine, Division of Hematology-Oncology and Molecular and Cellular

Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, Miami,

FL, and Stanford University School of Medicine, Stanford, CA.

1.. Address correspondence to Dr Natkunam: Dept of Pathology, Room L235,

Stanford University School of Medicine, Stanford, CA 94305.

Abstract

We studied the efficacy of 2 germinal center B-cell markers, HGAL and LMO2, in

the separation of lymphomas derived from small B cells, particularly follicular

lymphoma (FL) and marginal zone lymphoma occurring in nodal, extranodal,

splenic, and bone marrow sites using immunohistochemical analysis for CD10,

BCL6, BCL2, HGAL, and LMO2. Our results showed that HGAL and LMO2 are sensitive

and specific markers for detecting FL in nodal and extranodal sites. In

contrast, all markers were down-regulated in FL infiltrates in the bone marrow.

CD10 and HGAL were expressed in a subset of FLs in the bone marrow and were

highly correlated with each other and with CD21, a marker of follicular

dendritic cells. We conclude that HGAL and LMO2 should be considered in

immunohistochemical panels used for the routine workup of lymphomas derived from

small B cells. In the bone marrow, staining for HGAL or CD10 can be helpful in

making a diagnosis of FL, although they are absent in a subset of cases.

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