Guest guest Posted April 23, 2011 Report Share Posted April 23, 2011 BlankThe Efficacy of HGAL and LMO2 in the Separation of Lymphomas Derived From Small B Cells in Nodal and Extranodal Sites, Including the Bone Marrow 1.. Sheren F. Younes, MD1, 2.. H. Beck, MD1, 3.. S. Ohgami, MD, PhD1, 4.. Izidore S. Lossos, MD2, 5.. Levy, MD3, 6.. A. Warnke, MD1 and 7.. Yasodha Natkunam, MD, PhD1 + Author Affiliations 1.. 1From the Departments of Pathology and 2.. 3Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA; and 3.. 2Medicine, Division of Hematology-Oncology and Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, and Stanford University School of Medicine, Stanford, CA. 1.. Address correspondence to Dr Natkunam: Dept of Pathology, Room L235, Stanford University School of Medicine, Stanford, CA 94305. Abstract We studied the efficacy of 2 germinal center B-cell markers, HGAL and LMO2, in the separation of lymphomas derived from small B cells, particularly follicular lymphoma (FL) and marginal zone lymphoma occurring in nodal, extranodal, splenic, and bone marrow sites using immunohistochemical analysis for CD10, BCL6, BCL2, HGAL, and LMO2. Our results showed that HGAL and LMO2 are sensitive and specific markers for detecting FL in nodal and extranodal sites. In contrast, all markers were down-regulated in FL infiltrates in the bone marrow. CD10 and HGAL were expressed in a subset of FLs in the bone marrow and were highly correlated with each other and with CD21, a marker of follicular dendritic cells. We conclude that HGAL and LMO2 should be considered in immunohistochemical panels used for the routine workup of lymphomas derived from small B cells. In the bone marrow, staining for HGAL or CD10 can be helpful in making a diagnosis of FL, although they are absent in a subset of cases. Quote Link to comment Share on other sites More sharing options...
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