Re: Group devoted to intermittent fasting AND Mechanism by which CR retards ....

[Guest guest]

Hi!

There are two studies from from Heilbronn et al. on the effects of

alternate day fasting, including increased SIRT1 expression. I

acknowledge that this is a biomarker, not an actual health benefit. I

look forward to seeing results with people from Mattson's group.

(Search on MedLine for Mattson MP for his reviews and work with

rodents). My three-times-a-week fasts of about 24 hours are not much

different from having one big meal a day. Clearly, the duration of

fasts (fasting vs. meal spacing) is a big issue. Shorter fasts

sufficient to induce the desired response are certainly likely to be

healthier.

There is a lot of evidence that CR extends lifespan (at least in model

organisms) by inducing a regulatory network of gene activity,

including SIRT1, that somehow leads to an extension of lifespan.

There is good evidence (at least in worms) that this effect can be

separated from reduced metabolic activity per se. I have more to say

about this, including citations, on my blog,

http://stevemount.blogspot.com/2005/06/more-on-intermittent-fasting.html

and an earlier post, no. 18222 here, which is also at

http://stevemount.outfoxing.com/Posting0002.html.

Steve Mount

> Hi JW:

>

> Me too.

>

> Some months ago I emailed Fuhrman and another well known promoter who

> had a website advocating fasting, and earned his living giving advice

> on the subject. I asked them if they could refer me to studies from

> serious sources that showed fasting had health benefits. Neither >

> was able to do so.

>

> I believe Mattson should soon be coming out with a nine month study

> of 'one meal a day in early evening'. This may provide the first

> good look at the effects of a very modest degree of fasting. If it

> shows favorable results no doubt somewhat more radical fasting may

> get tested later.

,,,

> > Why a separate group? Because intermittent fasting is not the

> > same thing as caloric restriction!

> > Right!!!

[Guest guest]

Hi folks:

Of course for us CR people, what we are really interested to see is

what the effects of fasting are on people who are already on CR.

While fasting may be shown to replicate some of the effects of CR in

people consuming average numbers of calories, that would not

necessarily translate into a benefit for us.

But if fasting is shown to confer additional benefits to people

already on CR then I will bet the overwhelming majority of us would

jump on the band-wagon.

Does anyone know whether Mattson's study is in restrictors? Or are

the subjects principally ad lib?

Rodney.

> Hi!

>

> There are two studies from from Heilbronn et al. on the effects of

> alternate day fasting, including increased SIRT1 expression. I

> acknowledge that this is a biomarker, not an actual health benefit.

I

> look forward to seeing results with people from Mattson's group.

> (Search on MedLine for Mattson MP for his reviews and work with

> rodents). My three-times-a-week fasts of about 24 hours are not

much

> different from having one big meal a day. Clearly, the duration of

> fasts (fasting vs. meal spacing) is a big issue. Shorter fasts

> sufficient to induce the desired response are certainly likely to be

> healthier.

>

> There is a lot of evidence that CR extends lifespan (at least in

model

> organisms) by inducing a regulatory network of gene activity,

> including SIRT1, that somehow leads to an extension of lifespan.

> There is good evidence (at least in worms) that this effect can be

> separated from reduced metabolic activity per se. I have more to

say

> about this, including citations, on my blog,

> http://stevemount.blogspot.com/2005/06/more-on-intermittent-

fasting.html

> and an earlier post, no. 18222 here, which is also at

> http://stevemount.outfoxing.com/Posting0002.html.

>

> Steve Mount

>

> --- In , " Rodney " <perspect1111@y...>

wrote:

> > Hi JW:

> >

> > Me too.

> >

> > Some months ago I emailed Fuhrman and another well known promoter

who

> > had a website advocating fasting, and earned his living giving

advice

> > on the subject. I asked them if they could refer me to studies

from

> > serious sources that showed fasting had health benefits. Neither

>

> > was able to do so.

> >

> > I believe Mattson should soon be coming out with a nine month

study

> > of 'one meal a day in early evening'. This may provide the first

> > good look at the effects of a very modest degree of fasting. If

it

> > shows favorable results no doubt somewhat more radical fasting

may

> > get tested later.

> ,,,

>

> > > Why a separate group? Because intermittent fasting is not

the

> > > same thing as caloric restriction!

> > > Right!!!

[Guest guest]

Not to argue 24 hr fasting,

you say

Clearly, the duration of fasts (fasting vs. meal spacing) is a big issue. Shorter fasts sufficient to induce the desired response are certainly likely to be healthier. Do you mean less risky?

Regards.

----- Original Message -----

From: Steve Mount

Sent: Monday, June 20, 2005 11:53 AM

Subject: [ ] Re: Group devoted to intermittent fasting AND Mechanism by which CR retards ....

Hi! There are two studies from from Heilbronn et al. on the effects of alternate day fasting, including increased SIRT1 expression. Iacknowledge that this is a biomarker, not an actual health benefit. Ilook forward to seeing results with people from Mattson's group. (Search on MedLine for Mattson MP for his reviews and work withrodents). My three-times-a-week fasts of about 24 hours are not muchdifferent from having one big meal a day. Clearly, the duration offasts (fasting vs. meal spacing) is a big issue. Shorter fastssufficient to induce the desired response are certainly likely to behealthier. There is a lot of evidence that CR extends lifespan (at least in modelorganisms) by inducing a regulatory network of gene activity,including SIRT1, that somehow leads to an extension of lifespan. There is good evidence (at least in worms) that this effect can beseparated from reduced metabolic activity per se. I have more to sayabout this, including citations, on my blog,http://stevemount.blogspot.com/2005/06/more-on-intermittent-fasting.htmland an earlier post, no. 18222 here, which is also at http://stevemount.outfoxing.com/Posting0002.html. Steve Mount