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Re: Re: Diabetes Causes

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My BS has always been <90, and Insulin never measured, but I was wondering if we had other "clues" like we covered Waist/Hip ratios.

I think you have to be obese - really obese. So obesity is the first clue perhaps.

Just thinking about it.

I recall we have a chart of risk versus weight.

In files>CRON science>

/files/CRON%20SCIENCE/

Excel sheet and charts of CSPI plots of BMI vs disease risk.

Oddly - diabetes risk not as bad for men compared to women.

Risk doubles from 2- to 4- between BMI 26 and 27 for men. 1 is BMI 23.

And goes up 5 times between BMI 21 and 24 for women. 1 is BMI 21.

Regards.

----- Original Message -----

From: Rodney

Sent: Wednesday, July 06, 2005 11:21 AM

Subject: [ ] Re: Diabetes Causes

Hi JW:Dunno. But I had thought the indications of insulin resistance were higher than optimal fasting insulin and blood sugar. If I am mistaken, correction will be much appreciated.Rodney.> Thing left out - how do we know if we have IR?> > Regards.> > ----- Original Message ----- > From: Rodney > > Sent: Wednesday, July 06, 2005 9:50 AM> Subject: [ ] Diabetes Causes> > > Hi folks:> > Not exactly news to this group. But nice to see further confirmation:> > "Our findings suggest that it is adult body fat that alters a > person's risk of insulin resistance and type 2 diabetes in later > life. > > " ......................................... > > "The men and women with higher body fat and higher waist to hip > ratios were more likely to have insulin resistance - an earlier > warning sign of full-blown diabetes".> > http://news.bbc.co.uk/2/hi/health/4652521.stm> > Rodney.

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Thanks, Dianne,

Full text at:

http://www.annals.org/cgi/reprint/139/10/802.pdf

Fig on page 805, looks like triglyceride is pretty close to trig/HDL.

The subjects were BMI 25.1 to 33.7, age 35 to 64.

The cut point for trigylceride = 130 (1.47). Trig/HDL = 3.0 (1.8 in SI units).

I like the trig number.

BUT, even at 234# trig 178, hdl 31, I don't think I was ever IR. Other than being obese, BMI > 30, what does IR do?

I think things I can measure like BMI, W/H ratio, and exercise capability are things I can use.

Looks like the chart would indicate BMI < 25.1?

Regards.

----- Original Message -----

From: Diane Walter

Sent: Wednesday, July 06, 2005 11:30 AM

Subject: [ ] Re: Diabetes Causes

It looks like triglycerides vs HDL ratio might be a sensitiveindicator of insulin resistance:http://tinyurl.com/axscqDiane--- In , "jwwright" <jwwright@e...> wrote:> Thing left out - how do we know if we have IR?> > Regards.> > ----- Original Message ----- > From: Rodney > > Sent: Wednesday, July 06, 2005 9:50 AM> Subject: [ ] Diabetes Causes> > > Hi folks:> > Not exactly news to this group. But nice to see further confirmation:> > "Our findings suggest that it is adult body fat that alters a > person's risk of insulin resistance and type 2 diabetes in later > life. > > " ......................................... > > "The men and women with higher body fat and higher waist to hip > ratios were more likely to have insulin resistance - an earlier > warning sign of full-blown diabetes".> > http://news.bbc.co.uk/2/hi/health/4652521.stm> > Rodney.

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Hi All,

The definition of insulin resistance is:

Many people with noninsulin-dependent diabetes produce enough insulin, but their

bodies do not respond to the action of insulin. This may happen because the

person

is overweight and has too many fat cells, which do not respond well to insulin.

Also, as people age, their body cells lose some of the ability to respond to

insulin. Insulin resistance is also linked to high blood pressure and high

levels of

fat in the blood. Another kind of insulin resistance may happen in some people

who

take insulin injections. They may have to take very high doses of insulin every

day

(200 units or more) to bring their blood glucose (sugar) down to the normal

range.

--- Rodney <perspect1111@...> wrote:

> Hi JW:

>

> Dunno. But I had thought the indications of insulin resistance were

> higher than optimal fasting insulin and blood sugar.

Al Pater, PhD; email: old542000@...

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Right, Dianne and Rodney,

I kinda discount the trig/HDL ratio because I have genetically low HDL.

The trig correlation seems good but not too specific in the BMI 25 area,

So it appears to me it's not a positive marker for IR in the lower end of the range they reported, which is not the range we want to be anyway, IMO.

I want to be <25 for sure, possibly 20-23. But at BMI 26 the trig doesn't tell me what my Insulin is reliably. What's wrong with using BS?

It's a way for a doctor to figure something from the lipid data, but I would think the weight (BMI) of the patient would be enough. So, let's say that in terms of what I can measure each day, non invasively > weight, BP, W/H ratio, possibly Navy body fat %.

Blood test data is my doctor's choices. So insulin, CRP, homocysteine, etc are interesting but not something she wants to see.

Thinking about it, a new patient walks in, obviously obese (W/H ratio), what I'm thinking is he needs to get his weight down, start walking slowly at first, but I need to rule out a heart problem so an EKG comes first. If that looks ok and his step is sprightly, he can start walking. But if he moves slowly, maybe assisted >> cardiologist >> stress test.

IOW, what do I care about IR?

There's a member Lee Shurie, I recall, that licked his type 2 by not eating when his BS was high, delaying sometimes until 8PM. So he controlled hid calories regulated by a BS measurement. I controlled mine regulated by a BP measurement. I shoulda just controlled it by waist measurement years ago.

Regards.

----- Original Message -----

From: Diane Walter

Sent: Wednesday, July 06, 2005 1:55 PM

Subject: [ ] Re: Diabetes Causes

>> BUT, even at 234# trig 178, hdl 31, I don't think I was ever IR. Otherthan being obese, BMI > 30, what does IR do?I think things I can measure like BMI, W/H ratio, and exercisecapability are things I can use. Looks like the chart would indicate BMI < 25.1? >>Gee, Jim, I don't know if you can use any of those factors to confirmIR. I guess there's probably a correlation between higher BMI and IR,but certainly there are people with high BMI who never get IR.Diane

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