Guest guest Posted June 22, 2005 Report Share Posted June 22, 2005 Hi Diane: From the same author: An extraordinary 31% ADDITIONAL extension of lifespan in restricted mice supplemented with fish oil, compared with restricted mice supplemented with corn oil. Lifespan multiplied by 2.7 times in comparison with ad lib with corn oil. AMAZING!!! " Moderate food and/or energy (calorie) restriction delays age-related immune dysfunction and prolongs life span in multiple animal models. The amount and type of dietary fatty acids can also profoundly affect life span. Marine-derived fish oils contain (n-3) fatty acids, which have potent anti-inflammatory properties. We therefore examined the influence of food restriction (40% overall reduction in intake of all dietary components) combined with substitution of fish oil for corn oil in a factorial design. Autoimmune-prone (NZB x NZW)F(1) (B/W) mice, which develop fatal autoimmune renal disease, were used. The food-restricted/fish oil diet maximally extended median life span to 645 d (vs. 494 d for the food-restricted corn oil diet). Similarly, fish oil prolonged life span in the ad libitum–fed mice to 345 d (vs. 242 for the ad libitum/corn oil diet). " " These findings demonstrate the profound additive effects of food restriction and (n-3) fatty acids in prolonging life span in B/W mice. " PMID: 11584100 And: " ........... The beneficial effects of dietary restriction were shown in both the CD4 and CD8 T-lymphocyte subsets as well as in various immune compartments such as the spleen, mesenteric lymph nodes, peripheral blood, thymus, and salivary glands. In contrast, dietary restriction may have negative effects on macrophage function because recent evidence showed that dietary restriction rendered mice more susceptible to peritonitis and stimulated macrophages produced lower amounts of cytokines .................. " PMID: 15284365 Please keep feeding us with stuff from authors like this, Diane!!! Rodney. > Has this topic been discussed much on CRON? Here's a July 05 study I > found: > > http://www.co- clinicalnutrition.com/pt/re/conutrition/abstract.00075197-200507000- 00008.htm;jsessionid=C4ffKMyDzfyoWAFozYE7DiSymjVAw4q2oQejJfVrnMF2U58oP ErJ!-796981593!-949856031!9001!-1 > > > Diet manipulation and prevention of aging, cancer and autoimmune disease. > Current Opinion in Clinical Nutrition & Metabolic Care. 8(4):382- 387, > July 2005. > Jolly, A > > Abstract: > Purpose of review: Dietary supplementation and other dietary regimens > have become increasingly popular in the US population. Information > regarding how different dietary constituents interact when consumed > simultaneously is needed. This review examines the recent literature > on how different dietary constituents may interact physiologically > when consumed in combination. Furthermore, the potential human > relevance of calorie restriction and nonclassical function of vitamin > E is discussed. > > Recent findings: Long-term calorie restriction in monkeys has shown > similar beneficial effects as has been shown in rodents. Limited > calorie restriction studies in humans have shown promise in reducing > the incidence of heart disease and breast cancer. The combination of > calorie restriction and [omega]-3 fatty acids may be a more potent > antiinflammatory diet than either regimen alone. The type of fiber > that is most protective against colon cancer may be dependent on the > type of dietary fat consumed simultaneously. Vitamin E derivatives > that possess no antioxidant activity may be potent inhibitors of > cancer, but not normal, cell growth. > > Summary: Dietary modification has shown its greatest beneficial effect > when started prior to or immediately after the onset of disease. Also, > understanding how the subtypes or isoforms of nutrients function is > important since their physiological effects may be drastically > different. It is important to understand the entire dietary profile of > an individual when making dietary recommendations because one > nutrient, or dietary ingredient, may enhance or cancel out the > beneficial effects of another dietary ingredient. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2005 Report Share Posted June 22, 2005 Hi folks: Free full text of mice restricted with fish oil can be found here: http://www.nutrition.org/cgi/content/full/131/10/2753 Rodney. > > Has this topic been discussed much on CRON? Here's a July 05 study > I > > found: > > > > http://www.co- > clinicalnutrition.com/pt/re/conutrition/abstract.00075197-200507000- > 00008.htm;jsessionid=C4ffKMyDzfyoWAFozYE7DiSymjVAw4q2oQejJfVrnMF2U58oP > ErJ!-796981593!-949856031!9001!-1 > > > > > > Diet manipulation and prevention of aging, cancer and autoimmune > disease. > > Current Opinion in Clinical Nutrition & Metabolic Care. 8(4):382- > 387, > > July 2005. > > Jolly, A > > > > Abstract: > > Purpose of review: Dietary supplementation and other dietary > regimens > > have become increasingly popular in the US population. Information > > regarding how different dietary constituents interact when consumed > > simultaneously is needed. This review examines the recent literature > > on how different dietary constituents may interact physiologically > > when consumed in combination. Furthermore, the potential human > > relevance of calorie restriction and nonclassical function of > vitamin > > E is discussed. > > > > Recent findings: Long-term calorie restriction in monkeys has shown > > similar beneficial effects as has been shown in rodents. Limited > > calorie restriction studies in humans have shown promise in reducing > > the incidence of heart disease and breast cancer. The combination of > > calorie restriction and [omega]-3 fatty acids may be a more potent > > antiinflammatory diet than either regimen alone. The type of fiber > > that is most protective against colon cancer may be dependent on the > > type of dietary fat consumed simultaneously. Vitamin E derivatives > > that possess no antioxidant activity may be potent inhibitors of > > cancer, but not normal, cell growth. > > > > Summary: Dietary modification has shown its greatest beneficial > effect > > when started prior to or immediately after the onset of disease. > Also, > > understanding how the subtypes or isoforms of nutrients function is > > important since their physiological effects may be drastically > > different. It is important to understand the entire dietary profile > of > > an individual when making dietary recommendations because one > > nutrient, or dietary ingredient, may enhance or cancel out the > > beneficial effects of another dietary ingredient. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2005 Report Share Posted June 22, 2005 Survival curves: http://www.nutrition.org/content/vol131/issue10/images/medium/4w101178 5001.gif http://snipurl.com/fr1t The one on the extreme right is food restriction + fish oil. On the extreme left is ad lib + corn oil. Rodney. > > > Has this topic been discussed much on CRON? Here's a July 05 > study > > I > > > found: > > > > > > http://www.co- > > clinicalnutrition.com/pt/re/conutrition/abstract.00075197- 200507000- > > > 00008.htm;jsessionid=C4ffKMyDzfyoWAFozYE7DiSymjVAw4q2oQejJfVrnMF2U58oP > > ErJ!-796981593!-949856031!9001!-1 > > > > > > > > > Diet manipulation and prevention of aging, cancer and autoimmune > > disease. > > > Current Opinion in Clinical Nutrition & Metabolic Care. 8 (4):382- > > 387, > > > July 2005. > > > Jolly, A > > > > > > Abstract: > > > Purpose of review: Dietary supplementation and other dietary > > regimens > > > have become increasingly popular in the US population. Information > > > regarding how different dietary constituents interact when > consumed > > > simultaneously is needed. This review examines the recent > literature > > > on how different dietary constituents may interact physiologically > > > when consumed in combination. Furthermore, the potential human > > > relevance of calorie restriction and nonclassical function of > > vitamin > > > E is discussed. > > > > > > Recent findings: Long-term calorie restriction in monkeys has > shown > > > similar beneficial effects as has been shown in rodents. Limited > > > calorie restriction studies in humans have shown promise in > reducing > > > the incidence of heart disease and breast cancer. The combination > of > > > calorie restriction and [omega]-3 fatty acids may be a more potent > > > antiinflammatory diet than either regimen alone. The type of fiber > > > that is most protective against colon cancer may be dependent on > the > > > type of dietary fat consumed simultaneously. Vitamin E derivatives > > > that possess no antioxidant activity may be potent inhibitors of > > > cancer, but not normal, cell growth. > > > > > > Summary: Dietary modification has shown its greatest beneficial > > effect > > > when started prior to or immediately after the onset of disease. > > Also, > > > understanding how the subtypes or isoforms of nutrients function > is > > > important since their physiological effects may be drastically > > > different. It is important to understand the entire dietary > profile > > of > > > an individual when making dietary recommendations because one > > > nutrient, or dietary ingredient, may enhance or cancel out the > > > beneficial effects of another dietary ingredient. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2005 Report Share Posted June 22, 2005 Hi All, The article in question: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\ ct & list_uids=11584100 & query_hl=43 is free full text HTML available: http://www.nutrition.org/cgi/content/full/131/10/2753 and free pdf-available: http://www.nutrition.org/cgi/reprint/131/10/2753 That corn oil and autoimmune animals were used seemed to be potentially introducing the concept that less life span in the mice due to especially the corn oil per se. Also of note, seemed to be that isocaloric diets had effects on body weights of the mice, depending on the level and type of fat that was used. Now, here is a paper that seems to indicate that corn oil is indeed harmful to mice: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\ ct & list_uids=1938048 & query_hl=46 http://tinyurl.com/8el72 Growth Dev Aging. 1991 Summer;55(2):81-9. Body weight and longevity in genetically obese and non-obese mice fed fat-modified diets. BA, MS, Ballachey BE, Cramer DA, Sutherland TM. Polygenically obese and genetically related non-obese male mice were fed ad libitum purified diets differing in quantity or type of fat from weaning onward to determine effects upon weight gain and life span. Non-obese mice lived 71% longer than mice in the obese line (mean = 753 d versus 441 d). Obese mice fed a low-fat diet containing 1% corn oil by weight lived 26% longer than their obese counterparts fed high fat diets containing 20% additional fat as either corn oil or beef tallow. The low fat diet had more of a normalizing effect upon longevity than upon body weight in polygenically obese mice. Conversely, dietary fat concentration had little effect upon longevity in non-obese mice and more effect upon body weight than in genetically obese mice. Type of dietary fat had little effect upon body weight and no effect upon longevity. The results of this study suggest that life span was only partially explained by body weight, and furthermore, that genetics play a greater role than body weight or dietary fat concentration in determining life span. PMID: 1938048 --- Rodney <perspect1111@...> wrote: > Hi Diane: > > From the same author: > > An extraordinary 31% ADDITIONAL extension of lifespan in restricted > mice supplemented with fish oil, compared with restricted mice > supplemented with corn oil. Lifespan multiplied by 2.7 times in > comparison with ad lib with corn oil. AMAZING!!! Al Pater, PhD; email: old542000@... ____________________________________________________ Sports Rekindle the Rivalries. Sign up for Fantasy Football http://football.fantasysports. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 23, 2005 Report Share Posted June 23, 2005 Wow! This topic is near and dear to my heart. I've suffered chronic inflammation for nearly 25 years after developing arthritis in my knees. I had a bout of pericarditis (inflammation of the sac around the heart) about a year after the arthritis began and the doc said it was most likely related to the knees. I've continued to have all kinds of problems with inflamed joints - shoulder, hip, hands. Then, 7 years ago, with no family history and no risk factors other than having children in my mid 30s, I developed breast cancer. I've often wondered if inflammation might be the reason. Obviously Omega-3s are critical to an anti-inflammatory diet. I know to avoid simple carbohydrates and nightshades (waaa- I love tomatoes), and to eat lots of leafy dark green vegetables. It looks like CR may be an important key to reducing inflammation. If you run across other anti-inflammatory diet articles, I'd sure appreciate your passing them along. Diane > Survival curves: > > http://www.nutrition.org/content/vol131/issue10/images/medium/4w101178 > 5001.gif > > http://snipurl.com/fr1t > > The one on the extreme right is food restriction + fish oil. On the > extreme left is ad lib + corn oil. > > Rodney. > > Quote Link to comment Share on other sites More sharing options...
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