AW: 11q and no swollen nodes

[Guest guest]

How can i know which deletion i have without bone marrow biopsy?

Someone told me the Beta 2 Microglobulin can be helpful. I have 0.8g/dl

Thank you.

Davut

________________________________

Von: Koffman <briankoffman@...>

An:

Gesendet: Mittwoch, den 6. April 2011, 8:22:56 Uhr

Betreff: Re: 11q and no swollen nodes

Helene

The data on FCR shows that it works well in all 11q del. I do not

believe node size was teased out as a variable when looking at that

data, but I would suggest you read the whole CLL8 trial to see if it

buried somewhere

Having small nodes can only be good, because big nodes are hard to

treat and nodes are where the cancer grows much more so than the

marrow or blood

One caveat: With 11q del it is very possible to have small or no

palpable nodes and big mesenteric (gut) nodes, only seen on CAT scan.

That has been my situation twice.

Be well

On Apr 5, 2011, at 9:45 PM, elmerleb wrote:

Does anyone have, or know about, having an 11q deletion with no

swollen nodes?

Does this just mean very early disease, or do some 11qs not have this

manifestation?

I am wondering if a) no swelling means a less aggressive version of

11q - is there such a thing? and if FCR is the treatment of choice

for 11q, mainly because it is so effective on lymph nodes, does it

remain the treatment of choice if the person does not have swollen

nodes?

Thanks,

Heléne

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[Guest guest]

,

B2M is an important and cheap prognostic factor that rises with

disease burden. 0.8 is a great number

FISH testing or the newer micro arrays to look for the important

chromosome changes can be done on peripheral blood if the ALC is

elevated, no need fro a BMB

On Apr 6, 2011, at 12:51 AM, Alfred Alfredissimo wrote:

How can i know which deletion i have without bone marrow biopsy?

Someone told me the Beta 2 Microglobulin can be helpful. I have 0.8g/dl

Thank you.

Davut

________________________________

Von: Koffman <briankoffman@...>

An:

Gesendet: Mittwoch, den 6. April 2011, 8:22:56 Uhr

Betreff: Re: 11q and no swollen nodes

Helene

The data on FCR shows that it works well in all 11q del. I do not

believe node size was teased out as a variable when looking at that

data, but I would suggest you read the whole CLL8 trial to see if it

buried somewhere

Having small nodes can only be good, because big nodes are hard to

treat and nodes are where the cancer grows much more so than the

marrow or blood

One caveat: With 11q del it is very possible to have small or no

palpable nodes and big mesenteric (gut) nodes, only seen on CAT scan.

That has been my situation twice.

Be well

On Apr 5, 2011, at 9:45 PM, elmerleb wrote:

Does anyone have, or know about, having an 11q deletion with no

swollen nodes?

Does this just mean very early disease, or do some 11qs not have this

manifestation?

I am wondering if a) no swelling means a less aggressive version of

11q - is there such a thing? and if FCR is the treatment of choice

for 11q, mainly because it is so effective on lymph nodes, does it

remain the treatment of choice if the person does not have swollen

nodes?

Thanks,

Heléne

------------------------------------

Let's keep the list UNCLUTTERED!!!

To do ANY HOUSEKEEPING business such as changing the way you get mail,

please go

to mygoups or mail me at

scott_fs@...! Groups Links