Strawberry, cocoa, and plum fight MDA generation from high cholesterol

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I thought this was a somewhat rigorous demonstration of the potential value of dietary polyphenols in the context of hypercholesterolemia. The foods tested with strawberry, cocoa, and plum. Of course, maybe humans are "more protected" against this "pathology" than Rattus and Mus, but, it is not beyond the realm of possibility that such foods have intrinsic benefits.

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J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jul 8; [Epub ahead of print]

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Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits.Mateos R, Lecumberri E, Ramos S, Goya L, Bravo L.Instituto del Frio (CSIC), C/ Novais 10, Ciudad Universitaria, E-28040-Madrid, Spain.A high-performance liquid chromatography (HPLC) method to determine malondialdehyde (MDA) as the 2,4-dinitrophenylhydrazine (DNPH) derivative was applied to biological samples (serum and liver homogenates). Since MDA is considered a presumptive biomarker for lipid peroxidation in live organisms, a model for nutritionally induced oxidative stress (hypercholesterolemic rats) was studied in comparison with normocholesterolemic animals. The effect of diet supplementation with fruits rich in antioxidant polyphenols was assessed. The proposed method showed to be

precise and reproducible, as well as sensitive enough to reflect differences in the oxidative status in vivo. A significant decrease of serum and liver MDA concentrations in animals fed diets containing 0.3% of polyphenols from strawberry, cocoa or plum was observed in the normocholesterolemic groups. This reduction was especially noteworthy in the hypercholesterolemic animals, with increased MDA levels indicating enhanced lipid peroxidation in the controls, yet with values parallel to the normocholesterolemic groups in animals fed the polyphenol-rich diets. These results point out the beneficial effects of phenolic antioxidants from fruits in preventing oxidative damage in vivo.PMID: 16009604 [PubMed - as supplied by publisher]

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