Re: The Brains of Anorexics May be Different

[Guest guest]

Found a new (for me) fatty acid, which seems to effect delta 6 desaturase.

Anyone know about

eicosa-5,8,11,14-tetraynoic acid (ETYA) ?

Like where it's made, ingested, or what?

Appears a feedback control for making AA, but also look slike it would effect EPA pathway.

There's also an 5,8,11 eicosatriynoic acid (ETI).

Regards.

http://www.nutrition.org/cgi/content/abstract/130/6/1561?ijkey=0a16f307d73c95495a2bb7decb577f03cb2c1df6 & keytype2=tf_ipsecsha

"with and without eicosa-5,8,11,14-tetraynoic acid (ETYA) (200 mg/kg diet), a putative inhibitor of the -6 desaturase pathway. ETYA had no effect on food intake or weight gain, but it completely prevented 18:2(n-6) from suppressing the hepatic abundance of fatty acid synthase mRNA. ETYA ingestion was associated with a decrease in the hepatic content of 20:4(n-6) and an increase in the amount of 18:2(n-6). The fatty acid composition changes elicited by ETYA were accompanied by a decrease in the enzymatic activity of -6 desaturase. Interestingly, the hepatic abundance of -6 desaturase mRNA was actually induced by ETYA one- to twofold. When the product of -6 desaturase, i.e., 18:3(n-6), was added to the ETYA plus 18:2(n-6) diet, the hepatic content of 20:4(n-6) was normalized. In addition, 18:3(n-6) consumption reduced the level of hepatic -6 desaturase mRNA by 50% and completely prevented the increase in fatty acid synthase mRNA that was associated with ETYA ingestion. Apparently, -6 desaturation is an essential step for the PUFA regulation of the fatty acid synthase gene transcription. Finally, the suppression of -6 desaturase by PUFA and its induction by ETYA suggest that the -6 desaturase gene may be regulated by two different lipid-dependent mechanisms."

http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=5267213

5,8,11,14-Eicosatetraynoic acid, a competitive inhibitor of arachidonic acid metabolism, rapidly and reversibly inhibited DNA synthesis in U937 cells.^

PMID: 12837767

Arachidonic acid or 5,8,11,14-eicosatetraynoic acid (ETYA), a non-metabolized analog of arachidonic acid, induced a time-dependent inhibition of Na+ transport.