Guest guest Posted July 12, 2005 Report Share Posted July 12, 2005 <Snip> MONDAY, July 11 (HealthDay News) -- Curcumin, the ingredient that > gives curry its yellow hue, blocked the growth of melanoma tumor > cells and even stimulated their death in the laboratory, researchers > report. > <snip> I looked at the abstract, (PMID: 16007726 ) as the paper isn't yet available, but it seems like they tossed curcumin on 3 different melanoma lines, but all with a B-raf mutation. B-raf stimulates the cyclin pathway in melanocytes. Caveats: The abstract did not mention a control, such as a primary cell line or another cell line that did not show apoptosis in the presence of curcumin. It may be that curcumin is merely pro-apoptotic in all cell lines. Indeed, the authors have found that curcumin induces apoptosis in multiple myloma-derived cell lines (PMID: 12393461 ) and normal human pancreatic cells (PMID: 15476283 ). Cell culture is notorious for producing results that are not relevant at the organism level. Any cell that can grow in a dish for 1000s of generations is evolutionarily very far removed from one growing in an organism. Anyway, we should probably take this research with a grain of salt, as well as with a gram of turmeric. TK Quote Link to comment Share on other sites More sharing options...
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