Olive compound fights tumors in mice

[Guest guest]

Just an interesting piece of research, apparently there is a chemical in olives that seems to antagonize tumors....of course, I guess it is "just" an interesting lead at this point, but, the authors do seem to be aggressively trying to tie this in to the whole "Mediterranean effect".

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Biochemical and Biophysical Research Communications

Abstract

Oleuropein, a non-toxic secoiridoid derived from the olive tree, is a powerful antioxidant and anti-angiogenic agent. Here, we show it to be a potent anti-cancer compound, directly disrupting actin filaments in cells and in a cell-free assay. Oleuropein inhibited the proliferation and migration of advanced-grade human tumor cell lines in a dose-responsive manner. Using a novel tube-disruption assay, Oleuropein irreversibly rounded cancer cells, preventing their replication, motility, and invasiveness; these effects were reversible in normal cells. When administered orally to mice that developed spontaneous tumors, Oleuropein completely regressed tumors in 9–12 days. When tumors were resected prior to complete regression, they lacked cohesiveness and had a crumbly consistency. No viable cells could be recovered from these tumors. These observations elevate Oleuropein from a non-toxic antioxidant into a potent anti-tumor agent with direct effects against tumor cells. Our data may

also explain the cancer-protective effects of the olive-rich Mediterranean diet.

http://tinyurl.com/9cgta

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