Re: Postnatal overfeeding reduces max lifespan

[Guest guest]

As interesting as that is, I think you'll find parents and gparents alike will lean toward overfeeding. In fact to the point of colic (gas).

It's a practical/emotional aspect.

The one thing that formula feeding provides is exact measurement of intake. Of course breast pumping can provide that.

Then there's a mother's toxin issue. Surely the mother provides immunity, but that's accomplished in a few weeks.

One big issue was DHA which I think was a great addition to formula and that has been done in the popular formulas I checked. BTW, anyone wanting precise info can get online and order it from the mfgrs. DHA in formula is maybe more sure than mother's milk.

Recall that no one tests the mother's milk.

From a math standpoint, recall, that some of the rats die earlier than others, but if you compare curves, the CRed will be to the right, ie, live longer. BUT, can't SOME of the CRed rats die before the longer-lived non CRed?

Maybe a typical LE curve:

http://www.nutrition.org/content/vol131/issue10/images/medium/4w1011785001.gif

That top open triangle has to move farther to the right, like near vertical, IMO, before humans will deliberately underfeed human babies.

Regards.

----- Original Message -----

From: pct35768

Sent: Tuesday, July 05, 2005 8:27 AM

Subject: [ ] Postnatal overfeeding reduces max lifespan

I am a little concerned about the way infants are fed, as I am a little concerned about the "nod and wink" given to formula feeding. I think it is just too concentrated and anabolic to be "healthy", but, I guess only time will tell.In any case, these researchers working in rodents find that pre-natal "undernutrition" results in an appreciable decrement in lifespan. But, when you "overfeed" outside of the womb, then you get an even further reduction in lifespan, both average and maximum.This implies that postnatal "catchup" growth is one potent way of reducing your lifespan on "every conceivable level".But, even more interesting that those observations was the fact that these researchers are contending that the reduction in maximum lifespan was accompanied by an "early" *reduction* in body weight. This means that the "end" in this case is being mediated by that unusual "wasting away of aging" (quasi-cachexia?). My interpretation of that is there is a possibility that the "wrong" cells have turned "senescent", and therefore the "show" is over. Those could be stem cells, or progenitor cells, or some other group(s), and the exact "straw that breaks the camel's back" is not presently known, but it obviously is something that needs to be studied.=-=---=-=-==-=-Mech Ageing Dev. 2005 Aug;126(8):852-854. Epub 2005 Apr 9. Links Poor fetal growth followed by rapid postnatal catch-up growth leads to premature death.Ozanne SE, Hales C.Department of Clinical Biochemistry, University of Cambridge, Box 232, Level 4, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, UK.It is widely accepted that individuals with a low birth weight are at increased risk of developing type 2 diabetes, insulin resistance and cardiovascular disease. This risk is amplified if the poor fetal growth is followed by rapid postnatal catch-up growth. We have shown recently that poor fetal growth, resulting from maternal protein restriction, followed by postnatal catch-up growth is associated with reduced average longevity in mice. Here, we show that in addition to reduced average longevity, mice which have been growth restricted in utero and then grown rapidly during the lactation period have a reduced maximum longevity. Maximum longevity of these mice was, further, reduced when the animals were weaned onto an obesity-inducing cafeteria-style diet. This reduced maximum longevity was associated with early age-related weight loss. These results demonstrate that maternal nutrition during critical periods of development has a major impact on quantity as well as quality of life. - PMID: 15992609 http://tinyurl.com/atl97http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15992609=-=-=-==--=-=-=-==- T.pct35768@...