Postnatal overfeeding reduces max lifespan

[Guest guest]

I am a little concerned about the way infants are fed, as I am a

little concerned about the " nod and wink " given to formula feeding.

I think it is just too concentrated and anabolic to be " healthy " ,

but, I guess only time will tell.

In any case, these researchers working in rodents find that pre-

natal " undernutrition " results in an appreciable decrement in

lifespan. But, when you " overfeed " outside of the womb, then you get

an even further reduction in lifespan, both average and maximum.

This implies that postnatal " catchup " growth is one potent way of

reducing your lifespan on " every conceivable level " .

But, even more interesting that those observations was the fact that

these researchers are contending that the reduction in maximum

lifespan was accompanied by an " early " *reduction* in body weight.

This means that the " end " in this case is being mediated by that

unusual " wasting away of aging " (quasi-cachexia?). My interpretation

of that is there is a possibility that the " wrong " cells have

turned " senescent " , and therefore the " show " is over. Those could be

stem cells, or progenitor cells, or some other group(s), and the

exact " straw that breaks the camel's back " is not presently known,

but it obviously is something that needs to be studied.

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Mech Ageing Dev. 2005 Aug;126(8):852-854. Epub 2005 Apr 9. Links

Poor fetal growth followed by rapid postnatal catch-up growth leads

to premature death.

Ozanne SE, Hales C.

Department of Clinical Biochemistry, University of Cambridge, Box

232, Level 4, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR,

UK.

It is widely accepted that individuals with a low birth weight are at

increased risk of developing type 2 diabetes, insulin resistance and

cardiovascular disease. This risk is amplified if the poor fetal

growth is followed by rapid postnatal catch-up growth. We have shown

recently that poor fetal growth, resulting from maternal protein

restriction, followed by postnatal catch-up growth is associated with

reduced average longevity in mice. Here, we show that in addition to

reduced average longevity, mice which have been growth restricted in

utero and then grown rapidly during the lactation period have a

reduced maximum longevity. Maximum longevity of these mice was,

further, reduced when the animals were weaned onto an obesity-

inducing cafeteria-style diet. This reduced maximum longevity was

associated with early age-related weight loss. These results

demonstrate that maternal nutrition during critical periods of

development has a major impact on quantity as well as quality of

life. - PMID: 15992609

http://tinyurl.com/atl97

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15992609

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T.

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