Weight change vs. loss and insulin sensitivity

[Guest guest]

Hi All,

A CR paper seems to have evaded our attention, or to have been lost from the CR

archives.

Weight change via CR seems to increase our insulin sensitivity initially during

the

change, but insulin sensitivity increases at a reduced rate for the remainder of

the

weight loss, in an increase disproportionate to the weight loss. Then, having a

hiatus period before a second six-week period of CR seemed to somewhat reverse

this

increased sensitivity.

The below, which is free full-text to all, seems to suggest the above, at least

in

the grossly obese, in whom the insulin sensitivity is subject to the most

affect.

There seemed to be some interesting offshoot observations in the paper. When

the

subjects were asked to maintain calorie intakes to have a hiatus from the weight

loss changes of the two six-week periods of CR, although they did continue to

lose

some additional weight, maybe due to " carryover " CR, they became nonetheless

less

insulin sensitive. Why should this occur? Did the improvement of insulin

resistance " overshoot " due to the initiation of CR at the higher initial

six-week

period of relatively intense CR?

And, what about glucose changes? During the first week of the two six-week

periods,

there were changes that were distinct from the changes of the remaining five

weeks

of the CR. In the CR hiatus, the glucose levels improved, it seems.

Why should leptin during the final five weeks of CR change in a unique period?

Assali AR, Ganor A, Beigel Y, Shafer Z, Hershcovici T, Fainaru M.

Insulin resistance in obesity: body-weight or energy balance?

J Endocrinol. 2001 Nov;171(2):293-8.

PMID: 11691649

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=11691649 & query_hl=9

http://joe.endocrinology-journals.org/cgi/reprint/171/2/293

Al Pater, PhD; email: old542000@...

__________________________________________________

[Guest guest]

It has been obvious to me the human body does not react instantaneously to changes in diet. First, when overeating, weight is not added rather excretion is increased. It's like a servo system that says OK I see I have increased intake, but I don't believe it so I don't change long range parameters. A filter, if you will, for those knowledgeable of feedback control systems.

Later some weight is added slowly - notice this in youngers trying desperately to add weight for football. Later still the weight comes off very slowly. Fat stores are used and replaced with fluid as if awaiting the return of excess fat. Surely the body would not remove the storage pots immediately.

At some point the body accepts the new caloric level, hunger is reduced, fat stores are minimized, fat cells shrunken of fluid. But during all the period following the weight loss the body is eager to return to the high cal level and add weight.

A diet of Mar 20 to July 15, 2000 showed me weight does not fall but gradually until as if falling off a cliff it drops faster. Scary it was with talk of anorexia.

Made me think I should reverse the trend until I knew more about the mechanism - got some diff equations describing the process to understand the system. Still waiting for those. Too many variables. IR is just one variable of maybe a thousand.

IMO, first find the minimum to eat to maintain weight, then drop the intake, or increase exercise, to lose weight VERY slowly.

Regards.

----- Original Message -----

From: Al Pater

Sent: Monday, July 04, 2005 8:51 AM

Subject: [ ] Weight change vs. loss and insulin sensitivity

Hi All,A CR paper seems to have evaded our attention, or to have been lost from the CRarchives.Weight change via CR seems to increase our insulin sensitivity initially during thechange, but insulin sensitivity increases at a reduced rate for the remainder of theweight loss, in an increase disproportionate to the weight loss. Then, having ahiatus period before a second six-week period of CR seemed to somewhat reverse thisincreased sensitivity.The below, which is free full-text to all, seems to suggest the above, at least inthe grossly obese, in whom the insulin sensitivity is subject to the most affect.There seemed to be some interesting offshoot observations in the paper. When thesubjects were asked to maintain calorie intakes to have a hiatus from the weightloss changes of the two six-week periods of CR, although they did continue to losesome additional weight, maybe due to "carryover" CR, they became nonetheless lessinsulin sensitive. Why should this occur? Did the improvement of insulinresistance "overshoot" due to the initiation of CR at the higher initial six-weekperiod of relatively intense CR?And, what about glucose changes? During the first week of the two six-week periods,there were changes that were distinct from the changes of the remaining five weeksof the CR. In the CR hiatus, the glucose levels improved, it seems.Why should leptin during the final five weeks of CR change in a unique period?Assali AR, Ganor A, Beigel Y, Shafer Z, Hershcovici T, Fainaru M.Insulin resistance in obesity: body-weight or energy balance?J Endocrinol. 2001 Nov;171(2):293-8. PMID: 11691649http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=11691649 & query_hl=9http://joe.endocrinology-journals.org/cgi/reprint/171/2/293Al Pater, PhD; email: old542000@...