Richter's, Epstein-Barr Virus + B Cells After Fludarabine, Cyclosphosphamide

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Arch Pathol Lab Med. 2006 Aug;130(8):1227-30.

Concomitant epstein-barr virus-negative large B-cell lymphoma

(richter syndrome) and epstein-barr virus- positive B-cell

lymphoproliferation after treatment with fludarabine and

cyclophosphamide in a patient with B-cell chronic lymphocytic

leukemia.

Comperat E, Delmer A, Le Tourneau A, Molina TJ, Diebold J, Audouin J.

From the Service d'Anatomie et de Cytologie Pathologiques (Drs

Comperat, Le Tourneau, Molina, Diebold, and Audouin) and the Service

d'Hematologie (Dr Delmer), Hotel-Dieu, Paris, France.

We report the case of a patient treated with a combination of

fludarabine and cyclophosphamide after suffering from B-cell chronic

lymphocytic leukemia for 10 years.

Three months after treatment, the patient presented with an unusual

association, not previously reported in the literature: Richter

syndrome (monotypic Epstein-Barr virus- negative large B-cell

lymphoma) with the proliferation of Epstein-Barr virus-positive B

cells secreting a polytypic immunoglobulin A.

The Epstein-Barr virus-positive lymphoproliferation can be accounted

for by the type of immunosuppression induced by the treatment.

PMID: 16879030 [PubMed - in process