CR affect on bones

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Hi All,

See the pdf-available below. It has been is somewhat dated, but the bad details

of

CR's affect on bone health may be worth presentation of the details.

LaMothe JM, Hepple RT, Zernicke RF.

Selected contribution: Bone adaptation with aging and long-term caloric

restriction

in Fischer 344 x Brown-Norway F1-hybrid rats.

J Appl Physiol. 2003 Oct;95(4):1739-45. Epub 2003 Jun 13.

PMID: 12807893

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=12807893 & query_hl=26

http://jap.physiology.org/cgi/content/full/95/4/1739/TBL4

.... Table 4. Rat L6 vertebral mechanics

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Months-------8 28 28-CR 36

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Load at proportional limit, N 341±82 352±88 240±23*** 300±27

Load at proportional limit/mass, N/g 0.78±0.22 0.70±0.17 0.74±0.08 0.60±0.08

Stress at proportional limit, MPa 16.6±3.9 16.8±3.9 12.9±2.7 14.9±2.2

Strain at proportional limit, % 26.1±3.9 35.6±10.2 30.7±2.3 26.5±3.0

Maximal load, N 404±94 399±118 261±17*** 342±48

Maximal load/mass, N/g 1.26±0.28 0.80±0.23* 0.80±0.06* 0.69±0.11*

Stress at maximal load, MPa 18.6±4.5 18.2±4.2 13.5±2.6 16.3±3.4

Strain at maximal load, % 29.1±4.3 36.8±9.1 32.6±1.9 28.2±2.4

Stiffness, kN/mm 1.41±0.59 1.31±0.98 0.78±0.28 1.18±0.30

Stiffness/mass, kN·mm-1·g-1 3.23±1.48 2.64±1.95 2.42±0.86 2.36±0.59

Apparent elastic modulus, MPa 330±129 308±210 237±53 296±90

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Values are means±SD. *Significantly different from 8-mo mean (P </= 0.05).

**Significantly different from 36-mo and 28-mo mean (P </= 0.05). ...

Al Pater, PhD; email: old542000@...

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