Caffeinated coffee lowers breast cancer risk

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It has been a long time since someone has published any significant research attaching an elevated risk of a specific disease state to coffee consumption. Instead, they continue finding benefits. It is particularly interesting to note that they frequently find anti-cancer benefits to coffee consumption.

In rats, it has been shown that certain detoxification enzymes are induced by coffee consumption.

Additionally, cytological inquiries have elucidated the effects of caffeine on the cell cycle, and have shown that cancer cells are particularly sensitive to any influence that frustrates their carefully orchestrated expansion and invasive behavior....

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Int J Cancer. 2005 Jul 19; [Epub ahead of print]

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Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers.Nkondjock A, Ghadirian P, Kotsopoulos J, Lubinski J, Lynch H, Kim-Sing C, Horsman D, Rosen B, Isaacs C, Weber B, Foulkes W, Ainsworth P, Tung N, Eisen A, Friedman E, Eng C, Sun P, Narod SA.Epidemiology Research Unit, Research Centre, Centre Hospitalier de 'Universitaire de Montreal, CHUM Hotel-Dieu, Montreal, Canada.Although there are several plausible biologic mechanisms whereby coffee consumption might influence the risk of breast cancer,

epidemiologic evidence is limited. We assessed the association between coffee consumption and breast cancer risk among high-risk women who carry BRCA mutations. We performed a matched case-control analysis on 1,690 women with a BRCA1 or BRCA2 mutation from 40 centers in 4 countries. Average lifetime coffee consumption was estimated via a self-administered questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. After adjustment for potential confounders, the ORs for breast cancer in BRCA carriers who habitually drank 0, 1-3, 4-5 and 6 or more cups of coffee were 1.00, 0.90 (95% CI 0.72-1.12), 0.75 (95% CI 0.47-1.19) and 0.31 (95% CI 0.13-0.71; p-trend = 0.02). The effect was limited to the consumption of caffeinated coffee. These results suggest that among women with BRCA gene mutation, coffee consumption is unlikely to be harmful and that high levels of

consumption may in fact be related to reduced breast cancer risk. © 2005 Wiley-Liss, Inc.PMID: 16032702 [PubMed - as supplied by publisher]

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=16032702

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