Guest guest Posted July 15, 2005 Report Share Posted July 15, 2005 Rod: Dr Mirkin is a fine doctor (and in fact he is local, and my husband once went to his office for a checkup, but that's another story). No mention I notice of how much exercise. Walford also says to " keep fit " but that's about all. If exercise keeps your immune system " young " , what happened in the case of Lance Armstrong? Or anyone of a number of other athletes who either died from cancer or were lucky and survived it? Anecdotal to be sure, but statistics were posted recently about professional sportspersons and they are not particularly long lived. You might ask Dr Mirkin where this info comes from. (BTW I walk at least a mile a day, do yoga for about 50 min a day and do about 10 min of light weight lifting. I do believe in keeping fit.) on 7/15/2005 4:24 PM, Rodney at perspect1111@... wrote: Hi folks: I get Dr. Mirkin's regular email newsletter. He seems to be regarded around here as a source who is worth listening to. The following is an excerpt from a recent newsletter. Can anyone suggest where we can find supporting evidence for this? It seems a bit 'kooky' to me. I will email them and ask, also. ty " How Lack of Exercise Shortens Lives Many recent studies show that people die from inactivity, not just from aging. We know that as people age, they lose muscle, their immunities weaken and because of their weakened immunity, they are more likely to die of cancer and infectious diseases. As you age, you lose your ability to kill germs because of lack of muscle. When germs get into your body, you must make white blood cells and proteins called antibodies to kill them. Antibodies and cells are made from protein and the only place that you can store extra protein is in your muscles. When you have large muscles, you have a ready source of protein to make antibodies and cells. When you have small muscles, you have a very limited source of amino acids to make protein, so your immunity may be inadequate to kill germs. ................ " If this is true I should be exercising a lot more. And lifting weights, it seems. Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 16, 2005 Report Share Posted July 16, 2005 Hi Rodney, I agree it would be great to have a reference for this. Perhaps he would respond to an email request for this? You might let him know that you are involved in online discussion group for health . I like Dr. Mirkin too. Thanks for sharing his commentary. Rodney wrote: >Hi folks: > >I get Dr. Mirkin's regular email newsletter. He seems to be regarded >around here as a source who is worth listening to. The following is >an excerpt from a recent newsletter. Can anyone suggest where we can >find supporting evidence for this? It seems a bit 'kooky' to me. I >will email them and ask, also. ty > > " How Lack of Exercise Shortens Lives > >Many recent studies show that people die from inactivity, >not just from aging. We know that as people age, they lose >muscle, their immunities weaken and because of their weakened >immunity, they are more likely to die of cancer and infectious >diseases. As you age, you lose your ability to kill germs because >of lack of muscle. When germs get into your body, you must >make white blood cells and proteins called antibodies to kill them. >Antibodies and cells are made from protein and the only place that >you can store extra protein is in your muscles. When you have >large muscles, you have a ready source of protein to make >antibodies and cells. When you have small muscles, you have a >very limited source of amino acids to make protein, so your >immunity may be inadequate to kill germs. ................ " > >If this is true I should be exercising a lot more. And lifting >weights, it seems. > >Rodney. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 17, 2005 Report Share Posted July 17, 2005 IMO, Dr Mirkin and fitness people don't know what exercise is. Ref Austad's book:"Why we age". An excellent read. Pg 42:"People living in the bush in Papua New Guinea eat a low fat diet (less than 5%...) from necessity... Their daily life involves exercise at levels that would cripple or kill most Americans, even those athletically inclined. A friend of mine who has run dozens of marathons told me that a two day walk he took in the mountains of Papua ....was the hardest thing he had ever done." They say they have never had anyone die of a heart attack. {They} don't get atherosclerosis, and they live until their sixties or seventies." Regards. ----- Original Message ----- From: Rodney Sent: Friday, July 15, 2005 3:24 PM Subject: [ ] Exercise >>> Immunity Hi folks:I get Dr. Mirkin's regular email newsletter. He seems to be regarded around here as a source who is worth listening to. The following is an excerpt from a recent newsletter. Can anyone suggest where we can find supporting evidence for this? It seems a bit 'kooky' to me. I will email them and ask, also. ty"How Lack of Exercise Shortens LivesMany recent studies show that people die from inactivity, not just from aging. We know that as people age, they lose muscle, their immunities weaken and because of their weakened immunity, they are more likely to die of cancer and infectious diseases. As you age, you lose your ability to kill germs because of lack of muscle. When germs get into your body, you must make white blood cells and proteins called antibodies to kill them. Antibodies and cells are made from protein and the only place that you can store extra protein is in your muscles. When you have large muscles, you have a ready source of protein to make antibodies and cells. When you have small muscles, you have a very limited source of amino acids to make protein, so your immunity may be inadequate to kill germs. ................"If this is true I should be exercising a lot more. And lifting weights, it seems.Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 17, 2005 Report Share Posted July 17, 2005 More info on these people please. Why are they dying so young? > IMO, Dr Mirkin and fitness people don't know what exercise is. > > Ref Austad's book: " Why we age " . An excellent read. > Pg 42: " People living in the bush in Papua New Guinea eat a low fat diet (less than 5%...) from necessity... Their daily life involves exercise at levels that would cripple or kill most Americans, even those athletically inclined. A friend of mine who has run dozens of marathons told me that a two day walk he took in the mountains of Papua ....was the hardest thing he had ever done. " > They say they have never had anyone die of a heart attack. > > {They} don't get atherosclerosis, and they live until their sixties or seventies. " > > Regards. > > ----- Original Message ----- > From: Rodney > > Sent: Friday, July 15, 2005 3:24 PM > Subject: [ ] Exercise >>> Immunity > > > Hi folks: > > I get Dr. Mirkin's regular email newsletter. He seems to be regarded > around here as a source who is worth listening to. The following is > an excerpt from a recent newsletter. Can anyone suggest where we can > find supporting evidence for this? It seems a bit 'kooky' to me. I > will email them and ask, also. ty > > " How Lack of Exercise Shortens Lives > > Many recent studies show that people die from inactivity, > not just from aging. We know that as people age, they lose > muscle, their immunities weaken and because of their weakened > immunity, they are more likely to die of cancer and infectious > diseases. As you age, you lose your ability to kill germs because > of lack of muscle. When germs get into your body, you must > make white blood cells and proteins called antibodies to kill them. > Antibodies and cells are made from protein and the only place that > you can store extra protein is in your muscles. When you have > large muscles, you have a ready source of protein to make > antibodies and cells. When you have small muscles, you have a > very limited source of amino acids to make protein, so your > immunity may be inadequate to kill germs. ................ " > > If this is true I should be exercising a lot more. And lifting > weights, it seems. > > Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 21, 2005 Report Share Posted July 21, 2005 Hi folks: I emailed these people on 15 July and I haven't received a reply. Not encouraging. So if I do not get one soon I will send it again (perhaps they are on vacation?) and then if I still do not hear from them I will assume there is no evidence to support the claims made. The claims did seen rather extraordinary. Rodney. --- In , " Rodney " <perspect1111@y...> wrote: > Hi folks: > > I get Dr. Mirkin's regular email newsletter. He seems to be regarded > around here as a source who is worth listening to. The following is > an excerpt from a recent newsletter. Can anyone suggest where we can > find supporting evidence for this? It seems a bit 'kooky' to me. I > will email them and ask, also. ty > > " How Lack of Exercise Shortens Lives > > Many recent studies show that people die from inactivity, > not just from aging. We know that as people age, they lose > muscle, their immunities weaken and because of their weakened > immunity, they are more likely to die of cancer and infectious > diseases. As you age, you lose your ability to kill germs because > of lack of muscle. When germs get into your body, you must > make white blood cells and proteins called antibodies to kill them. > Antibodies and cells are made from protein and the only place that > you can store extra protein is in your muscles. When you have > large muscles, you have a ready source of protein to make > antibodies and cells. When you have small muscles, you have a > very limited source of amino acids to make protein, so your > immunity may be inadequate to kill germs. ................ " > > If this is true I should be exercising a lot more. And lifting > weights, it seems. > > Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 21, 2005 Report Share Posted July 21, 2005 > > Hi folks: > > > > I get Dr. Mirkin's regular email newsletter. He seems to be > regarded > > around here as a source who is worth listening to. The following > is > > an excerpt from a recent newsletter. Can anyone suggest where we > can > > find supporting evidence for this? It seems a bit 'kooky' to me. > I > > will email them and ask, also. ty > > > > " How Lack of Exercise Shortens Lives > > > > Many recent studies show that people die from inactivity, > > not just from aging. We know that as people age, they lose > > muscle, their immunities weaken and because of their weakened > > immunity, they are more likely to die of cancer and infectious > > diseases. As you age, you lose your ability to kill germs because > > of lack of muscle. When germs get into your body, you must > > make white blood cells and proteins called antibodies to kill > them. > > Antibodies and cells are made from protein and the only place that > > you can store extra protein is in your muscles. When you have > > large muscles, you have a ready source of protein to make > > antibodies and cells. When you have small muscles, you have a > > very limited source of amino acids to make protein, so your > > immunity may be inadequate to kill germs. ................ " > > > > If this is true I should be exercising a lot more. And lifting > > weights, it seems. > > > > Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 21, 2005 Report Share Posted July 21, 2005 It is MY understanding that the most long-lived people engage in frequent if not continuous physically demanding work throughout their lives, they don't sit on their butts posting a computer all day long. > > > Hi folks: > > > > > > I get Dr. Mirkin's regular email newsletter. He seems to be > > regarded > > > around here as a source who is worth listening to. The following > > is > > > an excerpt from a recent newsletter. Can anyone suggest where we > > can > > > find supporting evidence for this? It seems a bit 'kooky' to me. > > I > > > will email them and ask, also. ty > > > > > > " How Lack of Exercise Shortens Lives > > > > > > Many recent studies show that people die from inactivity, > > > not just from aging. We know that as people age, they lose > > > muscle, their immunities weaken and because of their weakened > > > immunity, they are more likely to die of cancer and infectious > > > diseases. As you age, you lose your ability to kill germs because > > > of lack of muscle. When germs get into your body, you must > > > make white blood cells and proteins called antibodies to kill > > them. > > > Antibodies and cells are made from protein and the only place that > > > you can store extra protein is in your muscles. When you have > > > large muscles, you have a ready source of protein to make > > > antibodies and cells. When you have small muscles, you have a > > > very limited source of amino acids to make protein, so your > > > immunity may be inadequate to kill germs. ................ " > > > > > > If this is true I should be exercising a lot more. And lifting > > > weights, it seems. > > > > > > Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 21, 2005 Report Share Posted July 21, 2005 A casual " 3 mile walk " is not exercise either, IMO. Not to me. That's not nearly enough. > It only takes an hour to walk 3 miles. I did mine. > Physically demanding jobs as in fishing in Finland is not healthy. > So we might break the " exercise " into > > physical work (where you can count the physics calories). > athletics, except weight lifting > weight lifting/body building > aerobic > > Work does not equal exercise. > > Regards. > > ----- Original Message ----- > From: drsusanforshey > > Sent: Thursday, July 21, 2005 4:54 PM > Subject: [ ] Re: Exercise >>> Immunity > > > It is MY understanding that the most long-lived people engage in > frequent if not continuous physically demanding work throughout their > lives, they don't sit on their butts posting a computer all day long. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 22, 2005 Report Share Posted July 22, 2005 I haven't had time to look up data yet (but I feel certain there are reams and reams of it). Here's what the AHA says: American Heart Association Recommendation For most healthy people: For health benefits to the heart, lungs and circulation, perform any moderate-to-vigorous-intensity aerobic activity for at least 30 minutes on most days of the week at 50-75 percent of your maximum heart rate. You can accumulate 30 minutes in 10 or 15 minute sessions. What's important is to include physical activity as part of a regular routine. These activities are ESPECIALLY beneficial when done regularly: * brisk walking, hiking, stair-climbing, aerobic exercise * jogging, running, bicycling, rowing and swimming * activities such as soccer and basketball that include continuous running The training effects of such activities are most apparent at exercise intensities that EXCEED 50 percent of a person's exercise capacity (maximum heart rate). If you're physically active regularly for longer periods or at greater intensity, you're likely to BENEFIT MORE. But don't overdo it. Too much exercise can give you sore muscles and increase the risk of injury. What about moderate-intensity activities? Even moderate-intensity activities, when performed daily, can have SOME long-term health benefits. They help lower the risk of cardiovascular diseases. Here are some examples: * walking for pleasure, gardening and yard work ( 3 MPH WALKS) * housework, dancing and prescribed home exercise * recreational activities such as tennis, racquetball, soccer, basketball and touch football What risk factors are reduced? Regular physical activity can also help reduce or eliminate some of these risk factors: * High blood pressure -- Regular aerobic activities can lower blood pressure. * Cigarette smoking -- Smokers who become physically active are more likely to cut down or stop smoking. * Diabetes -- People at their ideal weight are less likely to develop diabetes. Physical activity may also decrease insulin requirements for people with diabetes. * Obesity and overweight -- Regular physical activity can help people lose excess fat or stay at a reasonable weight. * High levels of triglycerides -- Physical activity helps reduce triglyceride levels. High triglycerides are linked to developing coronary artery disease in some people. * Low levels of HDL -- Low levels of HDL ( " good " ) cholesterol (less than 40 mg/dL) have been linked to a higher risk of coronary artery disease. Recent studies show that regular physical activity can significantly increase HDL cholesterol levels and thus reduce your risk. What are other benefits of physical activity? * Physical activity builds healthy bones, muscles and joints, and reduces the risk of colon cancer. Millions of Americans suffer from illnesses that can be prevented or improved through regular physical activity. * Physical activity also helps psychologically. It reduces feelings of depression and anxiety, improves mood and promotes a sense of well-being. * The 1996 Surgeon General's Report on Physical Activity also suggests that active people have a lower risk for stroke. --- In , " jwwright " <jwwright@e...> wrote: > Do you have some data to support that? > Risk/reward benefit, etc, - for humans. > > > ----- Original Message ----- > From: drsusanforshey > > Sent: Thursday, July 21, 2005 5:43 PM > Subject: [ ] Re: Exercise >>> Immunity > > > A casual " 3 mile walk " is not exercise either, IMO. Not to me. That's > not nearly enough. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 22, 2005 Report Share Posted July 22, 2005 Hi Francesca: And the New England Centenarian (NEC) Study found that there was absolutely no consistent relationship between exercise and longevity in their population of centenarians. They found a few who exercised extensively. Some moderately. Some modestly. Many never. Of those who did exercise, some walked, some lifted weights, some played occasional tennis, etc. etc.. It was, they said in an email to me that I posted about here some months ago: " all over the map. " This is, they said, the reason they do not mention exercise in the list on their website of the behaviours/characteristics typical of the centenarians they have studied. My opinion is that one will need a modest amount of exercise to enable one (modest endurance capacity, enough flexibility to pick things up off the floor, enough strength to move things that need to be moved) to do the things one will need to do when one gets to be 100. But apparently, from the NEC data, people can and do achieve that while taking no out-of-the-ordinary exercise at all. (And the average male lifespan in Okinawa, as we have discussed previously, is only about three years longer than it is in the US notwithstanding the atrocious average north American diet. Perhaps it is too much exercise that is keeping the Okinawa average lifespan below its potential?) Rodney. > > A casual " 3 mile walk " is not exercise either, IMO. Not to me. That's > not nearly enough. > --- In , " jwwright " <jwwright@e...> wrote: > > It only takes an hour to walk 3 miles. I did mine. > > Physically demanding jobs as in fishing in Finland is not healthy. > > So we might break the " exercise " into > > > > physical work (where you can count the physics calories). > > athletics, except weight lifting > > weight lifting/body building > > aerobic > > > > Work does not equal exercise. > > > > Regards. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 22, 2005 Report Share Posted July 22, 2005 Many here seem to think that the diet they have chosen for themselves will " save the day " for them. Preserve for them everything they may need as they get along with aging process. That very little else is necessary. I too believe CRON is the most important part of the equation. However, good nutrition and ~mild~ calorie restriction as practiced here will only do so much, only get you so far. I wish to " hedge my bet " and adopt an " OE " lifestyle (Optimum Exercise!) while I do my CRON thing too. I think this provides the other half of the equation and better indemnifies me against errors in nutritional judgement that I am surely bound to commit along this journey to 100+. These able-bodied centenarians are ~extremely~ lucky that it all came together for them in a most propitious manner! Many are not so lucky! Will you be so lucky? Will your chosen CRON keep you strong and robust into 100? Or is it wiser to hedge your bet with the practice OE too? I personally believe the best bet is to preserve as much youthful strength, endurance and vitality as possible, and stave off that insideous physical decline (that will most assuredly come) for as long as possible. At worst the excess exercise will do no harm. At best it just might attenuate some inadvertent and possibly chronic error in your nutritional judgement. CRON + OE = ! > > > It only takes an hour to walk 3 miles. I did mine. > > > Physically demanding jobs as in fishing in Finland is not healthy. > > > So we might break the " exercise " into > > > > > > physical work (where you can count the physics calories). > > > athletics, except weight lifting > > > weight lifting/body building > > > aerobic > > > > > > Work does not equal exercise. > > > > > > Regards. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 22, 2005 Report Share Posted July 22, 2005 Message: 4 Date: Fri, 22 Jul 2005 08:53:17 -0500 From: " jwwright " <jwwright@...> Subject: Re: Re: Exercise >>> Immunity Thanks, for posting the rec's, Diane. I agree with that, but realize when I started exercising I WAS at a lower level of exercise capability. Now I can do 3 miles in an hour easily (10% grade). Of course, I can walk farther than that, but I don't find it stimulating, with so many unknowns. And it doesn't cause me to strive higher. Doc says 30 mins per day, I do more than that. Plus outdoor work, call it casual, but I think moving a RR tie exceeds most our public's capability. I found I could still build muscle. At the end of a week I could move a 400#er. Just for kicks, I picked it off the ground. Silly me, being impressed with strength. That work, IMO, costs oxidation. Some of that may be good, because the body needs to " clean up " it's systems, perhaps. But extensive real work is silly. No proof it extends life, and lotsa experience it doesn't. --As I've CRawled my way down toward a longer-term-sustainable weight, I've exercised enough to maintain (actually enhance) the lean body mass I'll eventually be mostly left with. On the two days a week where I row hard and lift weights hard, I take a couple of grams of Vitamin C right before working out. --I can't quantify, of course, whether this does anything, but I figure that it can't hurt to consume it when my oxidative undertakings are going to be most condensed in time, and I end with rowing and ten minutes of yoga to try to minimize the lactic acid burden that I'll be taking out of the place I work out. Maco Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 22, 2005 Report Share Posted July 22, 2005 I am of the opinion that there may be ways to carefully increase physical activity with only minimal increases in food intake to compensate. I think the central confounding factor in most exercise related research is that any organism will be tempted to "overeat" after physical exertion of any sort. If this behavioral effect of exercise could be attenuated, then the benefits of exercise on "raw lifespan" might be more pronounced than more specific lab-based experimentation has been able to produce. There is a smattering of literature ascribing benefits to physical activity, but this is difficult to entirely distinguish from the notion that the variable of "physical activity" is simply another way of assessing "present functionality", which will become hopelessly entangled with aging itself, making any reduction in its quantity and quality as nothing more than a mere reflection of reduced physiologic capacity to shoulder the burden of an exercise regimen seen in the aging process itself. However, at the moment, the endocrinological effects of exercise would point one to the idea that it may "subtract" calories. However, dosing it appropriately to generate the dramatic effects seen in "plain vanilla" CR is not something that has been done in a convincing manner to date. =-=-=-=-=-=-==--= Mech Ageing Dev. 2005 Feb;126(2):327-31. Strategies to enhance longevity and independent function: the Jerusalem Longitudinal Study.Stessman J, Hammerman-Rozenberg R, Maaravi Y, Azoulai D, Cohen A.Department of Geriatrics and Rehabilitation, Hadassah-University Hospital, Mt. Scopus Campus P.O. Box 24035 Jerusalem, Israel. stessman@...PURPOSE: To analyze the impact of medical and social factors on survival and function from age 70 to 82 and point to possible genetic basis for differences. MATERIALS AND METHODS: Longitudinal, cohort study of a representative sample of Jerusalem residents, born 1920-1921. At age 70, 463 subjects underwent a thorough interview eliciting social determinants as well as a medical history and examination and laboratory investigation. At age 77,265 of the survivors, 71%, were re-examined. In 2002, all death certificates in Israel were reviewed. End points were performance of basic and advanced tasks with ease at age 77 and survival to age 82 or life span in subjects who had succumbed. The independent influence of each factor was tested using logistic regression. RESULTS: 89.6% of women were alive after 6 years and 77.4% after 12. Survival for men was 79.9% and 59.8%, respectively. Social factors predominated in the correlation with longer life: financial security, p=.0004; volunteer activity, p=.0002; regular exercise, p=.0002; positive self-assessed health, p<.0001; and activities of daily living (ADL) independence, p<.0001. Less striking but significant correlation for longevity was noted for avoiding naps, p=.04 and instrumental activities of daily living (IADL) independence, p=.048. Medical conditions associated with increased mortality included diabetes, p<.0001; coronary artery disease, p=.0002; impaired vision, p=.0007; and renal insufficiency, p=.008. Anemia and disturbed sleep did not independently correlate with mortality while the association with hypertension did not reach statistical significance, p=.056. In a regression to determine the independent impact of medical and social factors on mortality, unimpaired renal function, good vision, avoiding afternoon naps, volunteer or compensated work, physical activity and IADL independence all correlated with improved survival. Moreover, good vision, volunteer work or work for pay and physical activity were independently associated with continued ADL independence after 7 years. CONCLUSIONS: These findings highlight the ability of social, economic and functional factors to modify genetic influence on survival and function. Increased physical and social activity is an important tool to lengthen the span of robust function. The role of heredity in determining function and mortality may be expressed through diverse pathways.PMID: 15621214 [PubMed - indexed for MEDLINE] =-=-=-=-=-=-=-=-=-=-= J Appl Physiol. 2004 Feb;96(2):814-21. Epub 2003 Oct 10. Related Articles, Links Arm-cranking muscle power and arm isometric muscle strength are independent predictors of all-cause mortality in men.Metter EJ, Talbot LA, Schrager M, Conwit RA.Clinical Research Branch, National Institute on Aging, NIA-ASTRA, Harbor Hospital, Baltimore, land 21225, USA. metterj@...Poor muscle strength is associated with mortality, presumably due to low muscle mass. Notably, muscle power declines more rapidly than muscle strength with increasing age, which may be related to more complex central nervous system movement control. We examined arm-cranking power against four workloads and isometric strength measured in the upper extremities of 993 men longitudinally tested over a 25-yr period. Muscle mass was estimated by using 24-h creatinine excretion; physical activity was assessed by self-reported questionnaire. Muscle power and strength were modeled by time by using mixed-effects models, which developed regression equations for each individual. The first derivative of these equations estimated rate of change in strength or power at each evaluation. Survival analyses, using the counting method, examined the impact of strength, power, and their rates of change on all-cause mortality while adjusting for age. Arm-cranking power [relative risk (rr) = 0.984 per 100 kg.m.min(-1), P < 0.001] was a stronger predictor of mortality than was arm strength (rr = 0.986 per 10 kg, P = not significant), whereas rate of power change (rr = 0.989 per 100 kg.min(-1).yr(-1)) and rate of arm strength change (rr = 0.888 per 10 kg/yr) were risks independent of the power or strength levels. The impacts of power and strength were partially independent of muscle mass and physical activity. The risk of mortality was similar across the four power workloads (rr = 0.93-0.96 per 100 kg.m.min(-1)), whereas the lowest load generated less than one-half the power as the higher loads. Arm-cranking power is a risk factor for mortality, independent of muscle strength, physical activity, and muscle mass. The impact is found with loads that do not generate maximal power, suggesting an important role for motor coordination and speed of movement.PMID: 14555682 [PubMed - indexed for MEDLINE] =-=-=-=--=--=-==-=-=--=-==-=- Med Hypotheses. 2003 Jun;60(6):784-92. Related Articles, Links A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process. "If down-regulation of IGF-I activity could indeed slow aging in humans, a range of practical measures for achieving this may be at hand. These include a low-fat, whole-food, vegan diet, exercise training, soluble fiber, insulin sensitizers, appetite suppressants, and agents such as flax lignans, oral estrogen, or tamoxifen that decrease hepatic synthesis of IGF-I." =-=-=-=-=-=-=-=-=-=-=-=-=-= J Appl Physiol. 2004 Feb;96(2):450-4. Related Articles, Links Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro.Leung PS, Aronson WJ, Ngo TH, Golding LA, Barnard RJ.Department of Physiological Science, University of California, Los Angeles, California 90095, USA.Epidemiological studies report that regular physical activity can reduce the risk for prostate cancer, the most common solid-tumor cancer in US men. Regular exercise alters the serum IGF axis in vivo and reduces cell proliferation while increasing apoptosis in serum-stimulated LNCaP prostate cancer cells in vitro. The present study tests the hypothesis that these effects on tumor cell lines are mediated by enhancement of the function of the p53 gene known to arrest cell growth and induce apoptosis. When LNCaP cells were cultured in exercise serum and compared with control serum, cell growth was reduced by 27%, and there was a similar 33% decrease in proliferating cell nuclear antigen protein, a marker for cell cycling. Apoptosis was increased by 371% with the exercise serum, and there was a 100% increase in p53 protein (75.2 +/- 2.0 vs. 38.2 +/- 2.0 pg/microg protein). When serum was used to stimulate LN-56 cells, a cell line with nonfunctional p53 derived from LNCaP, no significant reduction in cell growth or increase in apoptosis with the exercise serum was observed. These results indicate that exercise training alters serum factors in vivo that increase cellular p53 protein content and is associated with reduced growth and induced apoptosis in LNCaP prostate cancer cells in vitro.PMID: 14715676 [PubMed - indexed for MEDLINE] ==-=--=--==--= T. pct35768@...__________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 22, 2005 Report Share Posted July 22, 2005 Hi folks: Well here is another perspective on this issue. Below I post excerpts from two studies. The first study (from Jeff's post) shows a behaviour that reduces the relative risk of all-cause mortality to 0.91 (or perhaps 0.87). The other shows a different behaviour that reduces the relative risk of mortality to 0.51. ==================== Here is the relevant excerpt from first study: MAIN OUTCOME MEASURE--All-cause mortality (3728 deaths). RESULTS-- Total energy expenditure and energy expenditure from vigorous activities, but not energy expenditure from nonvigorous activities, related inversely to mortality. After adjustment for potential confounders, the relative risks of dying associated with increasing quintiles of total energy expenditure were 1.00 (referent), 0.94, 0.95, 0.91 and 0.91, respectively (P [trend] < .05). The relative risks of dying associated with less than 630, 630 to less than 1680, 1680 to less than 3150, 3150 to less than 6300, and 6300 or more kJ/wk expended on vigorous activities were 1.00 (referent), 0.88, 0.92, 0.87, and 0.87, respectively (P [trend] = .007). Corresponding relative risks for energy expended on nonvigorous activities were 1.00 (referent), 0.89, 1.00, 0.98, and 0.92, respectively (P [trend] = .36). =================== Here is the relevant excerpt from the second study abstract: DESIGN--Prospective population study with baseline assessment of alcohol intake, smoking habit, income, education, and body mass index, and 10-12 years' follow up of mortality. SETTING--Copenhagen city heart study, Denmark. SUBJECTS--6051 men and 7234 women aged 30- 70 years. MAIN OUTCOME MEASURE--Number and time of cause-specific deaths from 1976 to 1988. RESULTS--The risk of dying steadily decreased with an increasing intake of wine--from a relative risk of 1.00 for the subjects who never drank wine to 0.51 (95% confidence interval 0.32 to 0.81) for those who drank three to five glasses a day. Intake of neither beer nor spirits, however, was associated with reduced risk. For spirits intake the relative risk of dying increased from 1.00 for those who never drank to 1.34 (1.05 to 1.71) for those with an intake of three to five drinks a day. The effects of the three types of alcoholic drinks seemed to be independent of each other, and no significant interactions existed with sex, age, education, income, smoking, or body mass index. Wine drinking showed the same relation to risk of death from cardiovascular and cerebrovascular disease as to risk of death from all causes. CONCLUSION--Low to moderate intake of wine is associated with lower mortality from cardiovascular and cerebrovascular disease and other causes. Similar intake of spirits implied an increased risk, while beer drinking did not affect mortality. PMID: 7767150 ================ As you can see, it appears that you can either exert yourself to the tune of more than 6300 kj/week and drop you mortality by nine percent, or, if you prefer, you can drink some wine daily and reduce it by 49%. As I have said here many times before, very little about nutrition/health is known for absolutely certain, so in this vacuum of unreliable information we each have to place our bets as regards what our behaviour should be based on our best judgment about what seems to make sense given the information we think we possess today. I plan to follow the advice suggested by both the above studies. But not in excess, and especially so, not the first. Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2005 Report Share Posted July 23, 2005 --- In , " jwwright " <jwwright@e...> wrote: > People die running, in fact, per Pritikin's book on running, Chapter titled: " Run and Die on the American diet " , Dr reported data from Rhode Island from 1975 to 1980: For each sedentary man 30 to 64 years of age who experienced sudden death, there were 7 joggers. " Jim, While I agree that people die running (I have a friend who did, but he also had genetically-caused high cholesterol), I have a very hard time believing this statistic. If it were true in general, then why does the American Heart Association recommend running? This statistic makes it sound like running is worse than smoking. Diane Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2005 Report Share Posted July 23, 2005 Hi folks: And at the risk of repeating misself [but for the benefit of those who are new or have poor memories (!)] do not forget the wisdom of Dr. , cardiologist at Cornell Medical Center, NYC, in his book 'The Exercise Myth' that ............. " ... fitness has absolutely nothing to do with health. " Rodney. > > > > People die running, in fact, per Pritikin's book on running, Chapter > titled: " Run and Die on the American diet " , Dr reported > data from Rhode Island from 1975 to 1980: For each sedentary man 30 to > 64 years of age who experienced sudden death, there were 7 joggers. " > > > Jim, > > While I agree that people die running (I have a friend who did, but he > also had genetically-caused high cholesterol), I have a very hard time > believing this statistic. If it were true in general, then why does > the American Heart Association recommend running? This statistic > makes it sound like running is worse than smoking. > > Diane Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2005 Report Share Posted July 23, 2005 --- In , " Rodney " <perspect1111@y...> wrote: > Hi folks: > > And at the risk of repeating misself [but for the benefit of those > who are new or have poor memories (!)] do not forget the wisdom of > Dr. , cardiologist at Cornell Medical Center, NYC, in his > book 'The Exercise Myth' that ............. " ... fitness has > absolutely nothing to do with health. " > > Rodney. > He also states in the book that, while we can shorten our 80 year life span, it is unlikely we can lengthen it. So he's not touting CR either. Diane Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2005 Report Share Posted July 23, 2005 " For each minute increase in maximal treadmill time between examinations, there was a corresponding 7.9% (P = .001) decrease in risk of mortality. " Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men S. N. Blair, H. W. Kohl 3rd, C. E. Barlow, R. S. Paffenbarger Jr, L. W. Gibbons and C. A. Macera Division of Epidemiology, Institute for Aerobics Research, Dallas, TX 75230, USA. OBJECTIVE--To evaluate the relationship between changes in physical fitness and risk of mortality in men. DESIGN--Prospective study, with two clinical examinations (mean interval between examinations, 4.9 years) to assess change or lack of change in physical fitness as associated with risk of mortality during follow-up after the subsequent examination (mean follow-up from subsequent examination, 5.1 years). SETTING--Preventive medicine clinic. STUDY PARTICIPANTS--Participants were 9777 men given two preventive medical examinations, each of which included assessment of physical fitness by maximal exercise tests and evaluation of health status. MAIN OUTCOME MEASURES--All cause (n = 223) and cardiovascular disease (n = 87) mortality. RESULTS--The highest age-adjusted all-cause death rate was observed in men who were unfit at both examinations (122.0/10,000 man-years); the lowest death rate was in men who were physically fit at both examinations (39.6/10,000 man-years). Men who improved from unfit to fit between the first and subsequent examinations had an age-adjusted death rate of 67.7/10,000 man-years. This is a reduction in mortality risk of 44% (95% confidence interval, 25% to 59%) relative to men who remained unfit at both examinations. Improvement in fitness was associated with lower death rates after adjusting for age, health status, and other risk factors of premature mortality. For each minute increase in maximal treadmill time between examinations, there was a corresponding 7.9% (P = .001) decrease in risk of mortality. Similar results were seen when the group was stratified by health status, and for cardiovascular disease mortality. CONCLUSIONS--Men who maintained or improved adequate physical fitness were less likely to die from all causes and from cardiovascular disease during follow-up than persistently unfit men. Physicians should encourage unfit men to improve their fitness by starting a physical activity program. 2)Exercise Capacity and the Risk of Death in Women The St Women Take Heart Project Martha Gulati, MD, MS; Dilip K. Pandey, PhD; Morton F. Arnsdorf, MD; Diane S. Lauderdale, PhD; A. Thisted, PhD; Roxanne H. Wicklund, RN; Arfan J. Al-Hani, MD{dagger}; Henry R. Black, MD Background— Cardiovascular disease is the leading cause of death among women and accounts for more than half of their deaths. Women have been underrepresented in most studies of cardiovascular disease. Reduced physical fitness has been shown to increase the risk of death in men. Exercise capacity measured by exercise stress test is an objective measure of physical fitness. The hypothesis that reduced exercise capacity is associated with an increased risk of death was investigated in a cohort of 5721 asymptomatic women who underwent baseline examinations in 1992. Methods and Results— Information collected at baseline included medical and family history, demographic characteristics, physical examination, and symptom-limited stress ECG, using the Bruce protocol. Exercise capacity was measured in metabolic equivalents (MET). Nonfasting blood was analyzed at baseline. A National Death Index search was performed to identify all-cause death and date of death up to the end of 2000. The mean age of participants at baseline was 52±11 years. Framingham Risk Score–adjusted hazards ratios (with 95% CI) of death associated with MET levels of <5, 5 to 8, and >8 were 3.1 (2.0 to 4.7), 1.9 (1.3 to 2.9), and 1.00, respectively. The Framingham Risk Score–adjusted mortality risk decreased by 17% for every 1-MET increase. Conclusions— This is the largest cohort of asymptomatic women studied in this context over the longest period of follow-up. This study confirms that exercise capacity is an independent predictor of death in asymptomatic women, greater than what has been previously established among men. The implications for clinical practice and health care policy are far reaching. " We have shown that exercise capacity is a strong independent predictor of all-cause death in asymptomatic women, after adjusting for traditional cardiac risk factors. For each unit (1 MET) increase in exercise capacity, there was a 17% reduction in mortality rate. Our data confirm the protective role of higher exercise capacity, even in the presence of established cardiac risk factors. Within this cohort of asymptomatic women, the risk of death doubled for those in the 5- to 8-MET exercise capacity category and tripled for those in the lowest (<5 MET) category when compared with the highest exercise capacity category and adjusted for the FRS. " > " Each 1-MET increase in exercise capacity conferred a 12 percent improvement in survival. " > > > > NEJM > > Volume 346:793-801 March 14, 2002 Number 11 > > > Exercise Capacity and Mortality among Men Referred for Exercise Testing > > Myers, Ph.D., Manish Prakash, M.D., Victor Froelicher, M.D., Dat Do, M.D., Sara Partington, B.Sc., and J. Edwin Atwood, M.D. > > > ABSTRACT > > Background Exercise capacity is known to be an important prognostic factor in patients with cardiovascular disease, but it is uncertain whether it predicts mortality equally well among healthy persons. There is also uncertainty regarding the predictive power of exercise capacity relative to other clinical and exercise-test variables. > > Methods We studied a total of 6213 consecutive men referred for treadmill exercise testing for clinical reasons during a mean (±SD) of 6.2±3.7 years of follow-up. Subjects were classified into two groups: 3679 had an abnormal exercise-test result or a history of cardiovascular disease, or both, and 2534 had a normal exercise-test result and no history of cardiovascular disease. Overall mortality was the end point. > > Results There were a total of 1256 deaths during the follow-up period, resulting in an average annual mortality of 2.6 percent. Men who died were older than those who survived and had a lower maximal heart rate, lower maximal systolic and diastolic blood pressure, and lower exercise capacity. After adjustment for age, the peak exercise capacity measured in metabolic equivalents (MET) was the strongest predictor of the risk of death among both normal subjects and those with cardiovascular disease. Absolute peak exercise capacity was a stronger predictor of the risk of death than the percentage of the age-predicted value achieved, and there was no interaction between the use or nonuse of beta-blockade and the predictive power of exercise capacity. Each 1-MET increase in exercise capacity conferred a 12 percent improvement in survival. > > Conclusions Exercise capacity is a more powerful predictor of mortality among men than other established risk factors for cardiovascular disease. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2005 Report Share Posted July 23, 2005 Hi All, The reference is: http://tinyurl.com/dgyxu or http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=11893790 & query_hl=9 in which there are: Comment in: N Engl J Med. 2002 Jul 25;347(4):288-90; author reply 288-90. N Engl J Med. 2002 Jul 25;347(4):288-90; author reply 288-90. N Engl J Med. 2002 Jul 25;347(4):288-90; author reply 288-90. N Engl J Med. 2002 Mar 14;346(11):852-4. These, I feel certainly details that your quotation is not a true indication of the certain results of the experiment. It appears to be more of a correlation than a cause-and-effect situation. There are likely to be reasons other than exercise for the higher longevity, it seems. --- In , " Jeff Novick " <jnovick@p...> wrote: > " Each 1-MET increase in exercise capacity conferred a 12 percent improvement in survival. " > > > > NEJM > > Volume 346:793-801 March 14, 2002 Number 11 > > > Exercise Capacity and Mortality among Men Referred for Exercise Testing > > Myers, Ph.D., Manish Prakash, M.D., Victor Froelicher, M.D., Dat Do, M.D., Sara Partington, B.Sc., and J. Edwin Atwood, M.D. > > > ABSTRACT > > Background Exercise capacity is known to be an important prognostic factor in patients with cardiovascular disease, but it is uncertain whether it predicts mortality equally well among healthy persons. There is also uncertainty regarding the predictive power of exercise capacity relative to other clinical and exercise-test variables. > > Methods We studied a total of 6213 consecutive men referred for treadmill exercise testing for clinical reasons during a mean (±SD) of 6.2±3.7 years of follow-up. Subjects were classified into two groups: 3679 had an abnormal exercise-test result or a history of cardiovascular disease, or both, and 2534 had a normal exercise-test result and no history of cardiovascular disease. Overall mortality was the end point. > > Results There were a total of 1256 deaths during the follow-up period, resulting in an average annual mortality of 2.6 percent. Men who died were older than those who survived and had a lower maximal heart rate, lower maximal systolic and diastolic blood pressure, and lower exercise capacity. After adjustment for age, the peak exercise capacity measured in metabolic equivalents (MET) was the strongest predictor of the risk of death among both normal subjects and those with cardiovascular disease. Absolute peak exercise capacity was a stronger predictor of the risk of death than the percentage of the age-predicted value achieved, and there was no interaction between the use or nonuse of beta-blockade and the predictive power of exercise capacity. Each 1-MET increase in exercise capacity conferred a 12 percent improvement in survival. > > Conclusions Exercise capacity is a more powerful predictor of mortality among men than other established risk factors for cardiovascular disease. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2005 Report Share Posted August 14, 2005 Another study in similar vein: " Role of host's antitumor immunity in exercise-dependent regression of murine T-cell lymphoma. Singh MP, Singh G, Singh SM. School of Biotechnology, Banaras Hindu University, Varanasi 221005, India. We have reported that the ascitic growth of a transplantable T cell lymphoma of spontaneous origin, designated as Dalton's lymphoma (DL), is associated with a concomitant immunosuppression. We have also reported that progressive in vivo growth of DL resulted in an inhibition of macrophage functions. In present investigation we report that physical exercise by DL-bearing mice, on a treadmill on a daily basis for various time durations for 10 days, increased the life span along with an inhibition of tumor growth. A significant decrease in the volume of ascitic fluid and number of cells in the tumor was obtained in mice, which underwent exercise. DL cells obtained from exercised groups showed a decreased proliferation in vitro. An augmentation in the percent of cells showing apoptotic morphology and percent specific DNA fragmentation was observed, suggesting that physical exercise increased the incidence of apoptosis in tumor cells. Moreover, macrophages obtained from tumor- bearing mice, which underwent exercise training, showed an augmented tumoricidal activity and production of tumoricidal molecules like interleukin-1 (IL-1), tumor necrosis factor (TNF) and nitric oxide (NO). On the basis of this study it is suggested that the regression of tumor growth consequent to physical exercise training of tumor bearing host, may be due to an exercise-dependent augmentation of macrophage tumoricidal functions. " PMID: 15857662 --- In , " Rodney " <perspect1111@y...> wrote: > " The exercise-induced enhancement of influenza immunity is mediated > in part by improvements in psychosocial factors in older adults. > > Kohut ML, Lee W, A, Arnston B, DW, Ekkekakis P, Yoon > KJ, Bishop A, Cunnick JE. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2005 Report Share Posted August 14, 2005 And another: " ....................... The findings from some, but not all, studies support the possibility that exercise may attenuate immunosenescence. .............. Taken together, the accumulated data suggest that exercise may be an efficacious therapy for restoring immune function in the elderly. In general, long term exercise interventions appear to show the most promise. Exercise related improvements have been reported with respect to antibody titre, T cell function, macrophage response, alterations of the T(H) 1/T(H)2 cytokine balance, the level of pro-inflammatory cytokines, and changes in naive/memory cell ratio. However, current data is minimal ............... " PMID: 15633584 Rodney. --- In , " Rodney " <perspect1111@y...> wrote: > And another. In particular note: " Whereas the suppressive effect > of heavy training on mucosal immunity is well documented ....... " Quote Link to comment Share on other sites More sharing options...
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