Supplemental Nutritional Support Lessens Acute GvHD After SCT

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Enteral* Feeding and Early Outcomes of Patients Undergoing Allogeneic

Stem Cell Transplantation Following Myeloablative Conditioning.

Brief Reports

Transplantation. 82(6):835-839, September 27, 2006.

Seguy, 1; Berthon, Celine 2; Micol, Jean-Baptiste 2; Darre,

Stephane 2; Dalle, Jean-Hugues 2; Neuville, Sylvain 3; Bauters,

Francis 2; Jouet, Jean-Pierre 2; Yakoub-Agha, Ibrahim 2,4

Abstract:

The purpose of this study was to evaluate the impact of enteral

nutrition on early outcome of patients after myeloablative allogeneic

stem cell transplantation (allo-SCT).

From January 2001 to January 2003, 22 patients agreed to receive

enteral nutrition via a nasogastric feeding tube; the remaining 23

patients received parenteral nutrition (n=22) or standard oral feeding

(n=1). Early complications and factors influencing 100-day overall

survival (OS) were investigated.

Patients who received enteral nutrition developed less often

acute-grade III/IV graft-versus-host disease (18%) than those who did

not (35%) (P=0.011). In addition, this group showed lower mortality

from infection during the first 100 days after transplantation.

In multivariate analyses, only the absence of enteral nutrition was

found to adversely influence 100-day OS with a hazard ratio of 8.3.

Enteral nutrition is a safe and effective method for feeding allo-SCT

patients. A randomized trial is warranted to confirm its advantage on

early patient outcome.

© 2006 Lippincott & Wilkins, Inc.

*Supplemental feeding via mouth or feeding tube.