potential gene-environment interaction for NHL

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Organochlorine exposure, immune gene variation, and risk of non-Hodgkin

lymphoma.

http://www.ncbi.nlm.nih.gov/pubmed/19066394

Organochlorine exposure has been linked to non-Hodgkin lymphoma (NHL) risk.

see also http://en.wikipedia.org/wiki/Organochloride

To determine whether this relationship is modified by immune gene variation, we

genotyped 61 polymorphisms in 36 immune genes in 1,172 NHL cases and 982

controls from the NCI-SEER study. We examined three exposures with elevated risk

in this study: PCB180 (plasma, dust measurements); the toxic equivalency

quotient (an integrated functional measure of several organochlorines) in

plasma; and alpha-chlordane (dust measurements, self-reported termiticide use).

Plasma (100 cases, 100 controls) and dust (682 cases, 513 controls) levels were

treated as natural log-transformed continuous variables. Unconditional logistic

regression was used to calculate beta coefficients and odds ratios, stratified

by genotype. Associations between all three exposures and NHL risk were limited

to the same genotypes for IFNG (C-1615T) TT and IL4 (5'-UTR, Ex1-168C>T) CC.

Associations between PCB180 in plasma and dust and NHL risk were limited to the

same genotypes for IL16 (3' UTR, Ex22+871A>G) AA, IL8 (T-251A) TT, and IL10

(A-1082G) AG|GG.

This shows that the relationship between organochlorine exposure and NHL risk

may be modified by particular variants in immune genes, and provides one of the

first examples of a potential gene-environment interaction for NHL.

PMID: 19066394

Colt JS, Rothman N, Severson RK, Hartge P, Cerhan JR, Chatterjee N, Cozen W,

Morton LM, De Roos AJ, S, Chanock S, Wang SS. Division of Cancer

Epidemiology and Genetics, National Cancer Institute, National Institutes of

Health, Department of Health and Human Services, Bethesda, MD, United States.