Guest guest Posted June 3, 2005 Report Share Posted June 3, 2005 Hi Al: I wonder if someone might be able to persuade Weindruch to provide us occasionally with a very brief update on the progress of this study? We do not need to wait until the final monkey dies, or there is conclusive evidence that maximal lifespan has been extended by CR. As was made clear by the University College, London study of a year ago comparative survival curves are very nearly as good. They give a pretty clear indication of what the final outcome is likely to be, many years before the experiment ends, and the full final article can be assembled and published. Simply a survival chart updated each time another monkey (in either group) dies, would be perfect. Or just the survival data in tabular form so that we can plot our own chart, would be fine too. Any thoughts? Rodney. --- In , Al Pater <old542000@y...> wrote: > Hi All, > > The below may be of interest. Although it discusses a previously presented study, > the comments by CR researchers are revealing. > > ' " I look forward to reporting the outcome, " [Weindruch] says, " assuming the monkeys > don't outlive me! " ' > > Nature 435, 548 (2 June 2005) | doi: 10.1038/nature03861 > > Yeast feeds debate on prolonging life > Carina Dennis > > 'Eating less helps you live longer' has for decades been the message from > researchers of ageing. So experts are not sure what to make of a study in flies that > suggests it could be what you eat, not how much you eat, that really counts. > > The idea that restricting calories prolongs lifespan was first reported in 1935, > following studies in rats. The observation has since been supported by studies in > species ranging from worms to dogs. The source of the calories is generally > considered irrelevant. > > Now a research team from University College London has extended the lifespan of > Drosophila flies by reducing the amount of yeast (a source of protein and fat) or > sugar in their diets. The team, led by Partridge, observed a much more > dramatic effect with yeast than with sugar, even though the overall change in > calorie content was the same. The results are published online in PLoS Biology this > week (W. Mair et al. 3, 223; 2005). > > The finding hints that reducing protein and fat might be the key to living longer, > rather than cutting down on the total number of calories. But many researchers are > sceptical of drawing any broad conclusions. " We already saw what a disaster it was > in the 1990s with fad diets that lowered fats and increased carbs, " says Leonard > Guarente, a molecular biologist at the Massachusetts Institute of Technology in > Cambridge. " That's when people really got fat. " > > He thinks the results may simply reflect a peculiarity of flies. " You need to know > how well flies metabolize glucose compared with yeast, " he says. > > Sige Zou, a fly geneticist at the National Institute on Aging in Baltimore, adds > that other components in the yeast might also be having an effect. " Yeast are made > up of a lot of ingredients, " he says. He would like to see the experiment repeated > using pure protein or fat extracts. > > Partridge's study shows how tricky it can be to pin down such effects, agrees > Weindruch, a gerontologist at the University of Wisconsin at Madison. " This > solidifies my concerns about the nuances and difficulties of conducting studies of > caloric restriction in some model organisms. " > > But researchers are sure, at least, that restricting calories does prolong lifespan, > even if they do not know how. " The name of the game is not to take in more energy > than you need, " says Guarente. > > How many calories would humans need to cut to gain years, or even decades? " Based on > our mouse data, I'd guess a minimum of 20% from a predetermined baseline, for a > person who is not obese, " says Weindruch. > > Weindruch is currently evaluating diet-restricted rhesus monkeys, in a study that > started more than a decade ago. " The monkeys are now middle-aged and it is clear the > diet is doing them good, " says Weindruch. They are protected from type II diabetes, > a common ailment in ageing monkeys, and seem to have healthier hearts. " I look > forward to reporting the outcome, " he says, " assuming the monkeys don't outlive me! " > > Al Pater, PhD; email: old542000@y... > > > > __________________________________ > Discover > Use to plan a weekend, have fun online and more. Check it out! > http://discover./ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 4, 2005 Report Share Posted June 4, 2005 Hi folks: Perhaps I should add one additional item to this request/suggestion: The cause of death would be very helpful too. It might help support the suspicion, as the data gradually accumulate, that those on CR have reduced their susceptibility to CVD to near zero. Rodney. > > Hi All, > > > > The below may be of interest. Although it discusses a previously > presented study, > > the comments by CR researchers are revealing. > > > > ' " I look forward to reporting the outcome, " [Weindruch] > says, " assuming the monkeys > > don't outlive me! " ' > > > > Nature 435, 548 (2 June 2005) | doi: 10.1038/nature03861 > > > > Yeast feeds debate on prolonging life > > Carina Dennis > > > > 'Eating less helps you live longer' has for decades been the > message from > > researchers of ageing. So experts are not sure what to make of a > study in flies that > > suggests it could be what you eat, not how much you eat, that > really counts. > > > > The idea that restricting calories prolongs lifespan was first > reported in 1935, > > following studies in rats. The observation has since been supported > by studies in > > species ranging from worms to dogs. The source of the calories is > generally > > considered irrelevant. > > > > Now a research team from University College London has extended the > lifespan of > > Drosophila flies by reducing the amount of yeast (a source of > protein and fat) or > > sugar in their diets. The team, led by Partridge, observed a > much more > > dramatic effect with yeast than with sugar, even though the overall > change in > > calorie content was the same. The results are published online in > PLoS Biology this > > week (W. Mair et al. 3, 223; 2005). > > > > The finding hints that reducing protein and fat might be the key to > living longer, > > rather than cutting down on the total number of calories. But many > researchers are > > sceptical of drawing any broad conclusions. " We already saw what a > disaster it was > > in the 1990s with fad diets that lowered fats and increased carbs, " > says Leonard > > Guarente, a molecular biologist at the Massachusetts Institute of > Technology in > > Cambridge. " That's when people really got fat. " > > > > He thinks the results may simply reflect a peculiarity of > flies. " You need to know > > how well flies metabolize glucose compared with yeast, " he says. > > > > Sige Zou, a fly geneticist at the National Institute on Aging in > Baltimore, adds > > that other components in the yeast might also be having an > effect. " Yeast are made > > up of a lot of ingredients, " he says. He would like to see the > experiment repeated > > using pure protein or fat extracts. > > > > Partridge's study shows how tricky it can be to pin down such > effects, agrees > > Weindruch, a gerontologist at the University of Wisconsin > at Madison. " This > > solidifies my concerns about the nuances and difficulties of > conducting studies of > > caloric restriction in some model organisms. " > > > > But researchers are sure, at least, that restricting calories does > prolong lifespan, > > even if they do not know how. " The name of the game is not to take > in more energy > > than you need, " says Guarente. > > > > How many calories would humans need to cut to gain years, or even > decades? " Based on > > our mouse data, I'd guess a minimum of 20% from a predetermined > baseline, for a > > person who is not obese, " says Weindruch. > > > > Weindruch is currently evaluating diet-restricted rhesus monkeys, > in a study that > > started more than a decade ago. " The monkeys are now middle-aged > and it is clear the > > diet is doing them good, " says Weindruch. They are protected from > type II diabetes, > > a common ailment in ageing monkeys, and seem to have healthier > hearts. " I look > > forward to reporting the outcome, " he says, " assuming the monkeys > don't outlive me! " > > > > Al Pater, PhD; email: old542000@y... > > > > > > > > __________________________________ > > Discover > > Use to plan a weekend, have fun online and more. Check it > out! > > http://discover./ Quote Link to comment Share on other sites More sharing options...
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