Two interesting articles: IF/CR and Amino Acid restriction

[Guest guest]

Those interested in comparing and contrasting IF and CR at the level of gene

expression for a group of enzymes involved in cholestrol ester metabolism

might find the following article worthy of their time:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed &

dopt=Abstract & list_uids=15888318 & query_hl=1

For those interested in amino acid restriction as a follow-up on the interesting

paper from yesterday which examed protein vs carbohydrate restriction in fruit

flies, I offer the following paper which investigates the effect of limiting a

sulfur-containing amino acid on longevity in various strains of rat:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed &

dopt=Abstract & list_uids=12543260 & query_hl=4

This second paper is interesting in as much as it, like the fly article,

questions

the assumption that the longevity effects of CR represent a single mechanism

preserved across a wide swath of biology. Instead the authors of these two

papers offer the alternative explaination that longevity is an example of

evolutionary convergence, i.e.animals have evolved more than a single

solution to the environmentally imposed problem of needing to address

swings in nutrient availability. Enjoy!