Spindler paper

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Hi All,

A new Spindler paper that is not pdf-available is below.

Spindler SR.

Rapid and reversible induction of the longevity, anticancer and genomic effects

of

caloric restriction.

Mech Ageing Dev. 2005 May 28; [Epub ahead of print]

PMID: 15927235

It is widely held that caloric restriction (CR) extends lifespan by preventing

or

reducing the age-related accumulation of irreversible molecular damage. In

contrast,

our results suggest that CR can act rapidly to begin life and health span

extension,

and that its rapid genomic effects are closely linked to its health effects. We

found that CR begins to extend lifespan and reduce cancer as a cause of death

within

8 weeks in older mice, apparently by reducing the rate of tumor growth. Further,

8

weeks of CR progressively reproduces nearly three quarters of the genomic

effects of

long-term CR (LTCR) in liver. Fewer of the genomic effects of LTCR are rapidly

reproduced by the initiation of CR in the heart, but the changes produced are

keys

to cardiovascular health. Thus, the genomic effects of CR may be established

more

rapidly in mitotic than in postmitotic tissues. Most of the genomic effects of

LTCR

dissipate 8 weeks after switching to a control diet. Consistent with these

results,

others have shown that acute CR rapidly and reversibly reduces the short-term

risk

of death in Drosophila to that of LTCR treated flies. Further, in late

adulthood,

acute CR partially or completely reverses age-related alterations of liver,

brain

and heart proteins. CR also rapidly and reversibly mitigates biomarkers of aging

in

adult rhesus macaques and humans. These data argue that highly conserved

mechanisms

for the rapid and reversible enhancement of life- and health-span exist for

mitotic

and postmitotic tissues.

Al Pater, PhD; email: old542000@...

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