Re: More on Pomegranate

[Guest guest]

Do we know how much they were consuming?

Thanks,

-

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi folks:

>

> This study was mentioned here a few months ago. Pretty remarkable

> results if they are confirmed:

>

> " Pomegranate juice consumption for 3 years by patients with

carotid

> artery stenosis reduces common carotid intima-media thickness,

blood

> pressure and LDL oxidation.

>

> Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld

L,

> Volkova N, Presser D, Attias J, Liker H, Hayek T.

>

> The Lipid Research Laboratory, Rappaport Family Institute for

> Research in the Medical Sciences, Rambam Medical Center, Haifa

31096,

> Israel. aviram@t...

>

> Dietary supplementation with polyphenolic antioxidants to animals

was

> shown to be associated with inhibition of LDL oxidation and

> macrophage foam cell formation, and attenuation of atherosclerosis

> development. We investigated the effects of pomegranate juice (PJ,

> which contains potent tannins and anthocyanins) consumption by

> atherosclerotic patients with carotid artery stenosis (CAS) on the

> progression of carotid lesions and changes in oxidative stress and

> blood pressure. Ten patients were supplemented with PJ for 1 year

and

> five of them continued for up to 3 years. Blood samples were

> collected before treatment and during PJ consumption. In the

control

> group that did not consume PJ, common carotid intima-media

thickness

> (IMT) increased by 9% during 1 year, whereas, PJ consumption

resulted

> in a significant IMT reduction, by up to 30%, after 1 year. The

> patients' serum paraoxonase 1 (PON 1) activity was increased by

83%,

> whereas serum LDL basal oxidative state and LDL susceptibility to

> copper ion-induced oxidation were both significantly reduced, by

90%

> and 59%, respectively, after 12 months of PJ consumption, compared

to

> values obtained before PJ consumption. Furthermore, serum levels

of

> antibodies against oxidized LDL were decreased by 19%, and in

> parallel serum total antioxidant status (TAS) was increased by

130%

> after 1 year of PJ consumption. Systolic blood pressure was

reduced

> after 1 year of PJ consumption by 21% and was not further reduced

> along 3 years of PJ consumption. For all studied parameters, the

> maximal effects were observed after 1 year of PJ consumption.

Further

> consumption of PJ, for up to 3 years, had no additional beneficial

> effects on IMT and serum PON1 activity, whereas serum lipid

> peroxidation was further reduced by up to 16% after 3 years of PJ

> consumption. The results of the present study thus suggest that PJ

> consumption by patients with CAS decreases carotid IMT and

systolic

> blood pressure and these effects could be related to the potent

> antioxidant characteristics of PJ polyphenols.

>

> PMID: 15158307 [PubMed - indexed for MEDLINE] "

>

> I don't like the use of the expression " ...... by up

to ....... "

> in the above abstract. It suggests a desire to exaggerate the

> benefits. Why not just say " by an average if 15% " (or whatever

the

> number is)? Because of that wording I would classify this study

> as 'interesting, but not to be taken seriously until confirmed',

fwiw

>

> Rodney.

[Guest guest]

Hi :

The study said 50 mls per day.

Rodney.

> > Hi folks:

> >

> > This study was mentioned here a few months ago. Pretty

remarkable

> > results if they are confirmed:

> >

> > " Pomegranate juice consumption for 3 years by patients with

> carotid

> > artery stenosis reduces common carotid intima-media thickness,

> blood

> > pressure and LDL oxidation.

> >

> > Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld

> L,

> > Volkova N, Presser D, Attias J, Liker H, Hayek T.

> >

> > The Lipid Research Laboratory, Rappaport Family Institute for

> > Research in the Medical Sciences, Rambam Medical Center, Haifa

> 31096,

> > Israel. aviram@t...

> >

> > Dietary supplementation with polyphenolic antioxidants to animals

> was

> > shown to be associated with inhibition of LDL oxidation and

> > macrophage foam cell formation, and attenuation of

atherosclerosis

> > development. We investigated the effects of pomegranate juice

(PJ,

> > which contains potent tannins and anthocyanins) consumption by

> > atherosclerotic patients with carotid artery stenosis (CAS) on

the

> > progression of carotid lesions and changes in oxidative stress

and

> > blood pressure. Ten patients were supplemented with PJ for 1 year

> and

> > five of them continued for up to 3 years. Blood samples were

> > collected before treatment and during PJ consumption. In the

> control

> > group that did not consume PJ, common carotid intima-media

> thickness

> > (IMT) increased by 9% during 1 year, whereas, PJ consumption

> resulted

> > in a significant IMT reduction, by up to 30%, after 1 year. The

> > patients' serum paraoxonase 1 (PON 1) activity was increased by

> 83%,

> > whereas serum LDL basal oxidative state and LDL susceptibility to

> > copper ion-induced oxidation were both significantly reduced, by

> 90%

> > and 59%, respectively, after 12 months of PJ consumption,

compared

> to

> > values obtained before PJ consumption. Furthermore, serum levels

> of

> > antibodies against oxidized LDL were decreased by 19%, and in

> > parallel serum total antioxidant status (TAS) was increased by

> 130%

> > after 1 year of PJ consumption. Systolic blood pressure was

> reduced

> > after 1 year of PJ consumption by 21% and was not further reduced

> > along 3 years of PJ consumption. For all studied parameters, the

> > maximal effects were observed after 1 year of PJ consumption.

> Further

> > consumption of PJ, for up to 3 years, had no additional

beneficial

> > effects on IMT and serum PON1 activity, whereas serum lipid

> > peroxidation was further reduced by up to 16% after 3 years of PJ

> > consumption. The results of the present study thus suggest that

PJ

> > consumption by patients with CAS decreases carotid IMT and

> systolic

> > blood pressure and these effects could be related to the potent

> > antioxidant characteristics of PJ polyphenols.

> >

> > PMID: 15158307 [PubMed - indexed for MEDLINE] "

> >

> > I don't like the use of the expression " ...... by up

> to ....... "

> > in the above abstract. It suggests a desire to exaggerate the

> > benefits. Why not just say " by an average if 15% " (or whatever

> the

> > number is)? Because of that wording I would classify this study

> > as 'interesting, but not to be taken seriously until confirmed',

> fwiw

> >

> > Rodney.