Exercise can increase insulin sensitivity

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Exercise should be a part of your longevity program.

" Insulin resistance predisposes to cardiovascular disease and shortens

human lifespan " , but " exercise can increase insulin sensitivity " ,

according to the following abstract.

Tony

=========

Int J Sports Med. 2000 Jan;21(1):1-12.

Exercise and insulin sensitivity: a review.

Borghouts LB, Keizer HA.

Department of Movement Sciences, Maastricht University, The

Netherlands. lars.borghouts@...

Physical activity has a beneficial effect on insulin sensitivity

in normal as well as insulin resistant populations. A distinction

should be made between the acute effects of exercise and genuine

training effects. Up to two hours after exercise, glucose uptake is in

part elevated due to insulin independent mechanisms, probably

involving a contraction-induced increase in the amount of GLUT4

associated with the plasma membrane and T-tubules. However, a single

bout of exercise can increase insulin sensitivity for at least 16 h

post exercise in healthy as well as NIDDM subjects. Recent studies

have accordingly shown that acute exercise also enhances insulin

stimulated GLUT4 translocation. Increases in muscle GLUT4 protein

content contribute to this effect, and in addition it has been

hypothesized that the depletion of muscle glycogen stores with

exercise plays a role herein. Physical training potentiates the effect

of exercise on insulin sensitivity through multiple adaptations in

glucose transport and metabolism. In addition, training may elicit

favourable changes in lipid metabolism and can bring about

improvements in the regulation of hepatic glucose output, which is

especially relevant to NIDDM. It is concluded that physical training

can be considered to play an important, if not essential role in the

treatment and prevention of insulin insensitivity.

PMID: 10683091

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi folks:

>

> This study was commented on previously, but I don't believe the

> actual study was posted. So here it is:

>

> " Rise in insulin resistance is associated with escalated telomere

> attrition.

>

> Gardner JP, Li S, Srinivasan SR, Chen W, Kimura M, Lu X, Berenson

GS,

> Aviv A.

>

> Hypertension Research Center, Cardiovascular Research Institute,

> University of Medicine and Dentistry of New Jersey, New Jersey

> Medical School, Newark, NJ 07103, USA.

>

> BACKGROUND: Insulin resistance predisposes to cardiovascular

disease

> and shortens human lifespan. We therefore tested the hypothesis

that

> a rise in insulin resistance in concert with gain in body mass is

> associated with accelerated white blood cell telomere attrition.

> METHODS AND RESULTS: We measured white blood cell telomere dynamics

> and age-related changes in insulin resistance and body mass index

in

> young adults of the Bogalusa Heart Study. Over 10.1 to 12.8 years,

> the relative changes in telomere length were correlated with the

> homeostasis model assessment of insulin resistance (r=-0.531,

> P<0.001) and changes in the body mass index (r=-0.423, P<0.001).

> CONCLUSIONS: These findings provide the first tangible nexus of

> telomere biology with insulin resistance and adiposity in humans.

>

> PMID: 15851602 [PubMed - in process] "

>

> Rodney.