Guest guest Posted May 30, 2005 Report Share Posted May 30, 2005 Nick, Metformin lowers insulin and is used for diabetes treatment, whereas resveratrol activates a gene associated with longevity. The exploration of these substances for achieving longevity tries to mimick the beneficial effects of caloric restriction without the sacrifice of eating less. (You can eat your cake, and take a pill to live longer anyway). So far, nothing has been found to be better than caloric restriction. You will probably not find reliable hard data for the next 20 years. Tony === CDC's Research Agenda Strives to Build Foundation for Public Health Action http://www.cdc.gov/nccdphp/cdnr/cdnr_winter0203.htm " The 27-center clinical trial was designed to determine whether a healthy diet and regular exercise could help at least 10 million Americans at high risk for type 2 diabetes sharply lower their chances of getting the disease. The study, in which 3,234 people with IGT participated, compared the effects of a healthy diet and regular exercise with the effects of treatment with the drug metformin. The trial actually ended a year early because the data clearly demonstrated that the lifestyle changes were more effective than metformin. " === J Biol Chem. 2005 Apr 29;280(17):17038-45. Epub 2005 Jan 31. Substrate-specific activation of sirtuins by resveratrol. Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA. Resveratrol, a small molecule found in red wine, is reported to slow aging in simple eukaryotes and has been suggested as a potential calorie restriction mimetic. Resveratrol has also been reported to act as a sirtuin activator, and this property has been proposed to account for its anti-aging effects. We show here that resveratrol is a substrate-specific activator of yeast Sir2 and human SirT1. In particular, we observed that, in vitro, resveratrol enhances binding and deacetylation of peptide substrates that contain Fluor de Lys, a non-physiological fluorescent moiety, but has no effect on binding and deacetylation of acetylated peptides lacking the fluorophore. Consistent with these biochemical data we found that in three different yeast strain backgrounds, resveratrol has no detectable effect on Sir2 activity in vivo, as measured by rDNA recombination, transcriptional silencing near telomeres, and life span. In light of these findings, the mechanism accounting for putative longevity effects of resveratrol should be reexamined. PMID: 15684413 > Hello all, first post here: > > I have read about 2 potential drugs that may extend maximum lifespan. > Metformin and resveratrol. Both have been the subject of articles in > LifeExtension however I have been unable to find much followup > information. Anyone know of any followup studies with real hard data? > > Thanks, > > Nick Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2005 Report Share Posted May 30, 2005 --- In , " lenalena " <citpeks@y...> wrote: > Nick, > > Metformin lowers insulin and is used for diabetes treatment, whereas > resveratrol activates a gene associated with longevity. The > exploration of these substances for achieving longevity tries to > mimick the beneficial effects of caloric restriction without the > sacrifice of eating less. (You can eat your cake, and take a pill to > live longer anyway). So far, nothing has been found to be better than > caloric restriction. You will probably not find reliable hard data > for the next 20 years. > > Tony > Thanks Tony for your response. I am aware that nothing has been shown to be better than CR (or as good!) but it doesn't have to be better to still be of value. An experiment with rodents of only 4-5 years duration would give a pretty good idea wouldn't it? While I am persuaded that CR works, it requires a discipline that few have. Quote Link to comment Share on other sites More sharing options...
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