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Re: Question from a new member (Metformin and resveratrol)

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Nick,

Metformin lowers insulin and is used for diabetes treatment, whereas

resveratrol activates a gene associated with longevity. The

exploration of these substances for achieving longevity tries to

mimick the beneficial effects of caloric restriction without the

sacrifice of eating less. (You can eat your cake, and take a pill to

live longer anyway). So far, nothing has been found to be better than

caloric restriction. You will probably not find reliable hard data

for the next 20 years.

Tony

===

CDC's Research Agenda Strives to Build Foundation for Public

Health Action

http://www.cdc.gov/nccdphp/cdnr/cdnr_winter0203.htm

" The 27-center clinical trial was designed to determine whether a

healthy diet and regular exercise could help at least 10 million

Americans at high risk for type 2 diabetes sharply lower their chances

of getting the disease. The study, in which 3,234 people with IGT

participated, compared the effects of a healthy diet and regular

exercise with the effects of treatment with the drug metformin. The

trial actually ended a year early because the data clearly

demonstrated that the lifestyle changes were more effective than

metformin. "

===

J Biol Chem. 2005 Apr 29;280(17):17038-45. Epub 2005 Jan 31.

Substrate-specific activation of sirtuins by resveratrol.

Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell

SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK.

Department of Genome Sciences, University of Washington, Seattle,

Washington 98195, USA.

Resveratrol, a small molecule found in red wine, is reported to

slow aging in simple eukaryotes and has been suggested as a potential

calorie restriction mimetic. Resveratrol has also been reported to act

as a sirtuin activator, and this property has been proposed to account

for its anti-aging effects. We show here that resveratrol is a

substrate-specific activator of yeast Sir2 and human SirT1. In

particular, we observed that, in vitro, resveratrol enhances binding

and deacetylation of peptide substrates that contain Fluor de Lys, a

non-physiological fluorescent moiety, but has no effect on binding and

deacetylation of acetylated peptides lacking the fluorophore.

Consistent with these biochemical data we found that in three

different yeast strain backgrounds, resveratrol has no detectable

effect on Sir2 activity in vivo, as measured by rDNA recombination,

transcriptional silencing near telomeres, and life span. In light of

these findings, the mechanism accounting for putative longevity

effects of resveratrol should be reexamined.

PMID: 15684413

> Hello all, first post here:

>

> I have read about 2 potential drugs that may extend maximum

lifespan.

> Metformin and resveratrol. Both have been the subject of articles

in

> LifeExtension however I have been unable to find much followup

> information. Anyone know of any followup studies with real hard

data?

>

> Thanks,

>

> Nick

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--- In , " lenalena " <citpeks@y...>

wrote:

> Nick,

>

> Metformin lowers insulin and is used for diabetes treatment, whereas

> resveratrol activates a gene associated with longevity. The

> exploration of these substances for achieving longevity tries to

> mimick the beneficial effects of caloric restriction without the

> sacrifice of eating less. (You can eat your cake, and take a pill

to

> live longer anyway). So far, nothing has been found to be better

than

> caloric restriction. You will probably not find reliable hard data

> for the next 20 years.

>

> Tony

>

Thanks Tony for your response. I am aware that nothing has been shown

to be better than CR (or as good!) but it doesn't have to be better

to

still be of value. An experiment with rodents of only 4-5 years

duration would give a pretty good idea wouldn't it? While I am

persuaded that CR works, it requires a discipline that few have.

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