The aiolos transcription factor is up-regulated in chronic lymphocytic leukemia

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The aiolos transcription factor is up-regulated in chronic lymphocytic leukemia.

nne Duhamel, Issam Arrouss, Helene Merle-Beral, and Angelita Rebollo

Blood, January 9, 2008;

Immunologie Cellulaire et Tissulaire, Inserm U543 and Universite Pierre et Marie

Curie, Hopital Pitie-Salpetriere, Paris, France.

The Aiolos transcription factor, member of the Ikaros family of zinc-finger

proteins, plays an important role in the control of mature B lymphocyte

differentiation and proliferation and its function appears to be modulated

through alternative splicing. In order to assess Aiolos isoform role in humans'

pathologies, we studied Aiolos variant distribution and expression in mature B

lymphoproliferative disorders (chronic lymphocytic leukemia and other B-cell

lymphomas). We demonstrated that over 80% of expressed Aiolos in normal as well

as in malignant B cells is of the hAio1 type and we showed for the first time a

homogeneous overexpression of the total amounts of Aiolos transcripts in the B

cells of CLL patients, independently of ZAP-70 and IgVH mutational status

prognosis factors. This up-regulation of Aiolos, confirmed at protein level,

seems independent of Aiolos promoter H3K9 acetylation and H3K4 trimethylation.

PMID: 18184862