Discordance of ZAP-70 in patients with chronic lymphocytic leukemia.

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Discordance of ZAP-70 in patients with chronic lymphocytic leukemia.

BT Chaar, AK Schergen, and LE Grosso

Int J Lab Hematol, February 1, 2008; 30(1): 36-40.

Department of Internal Medicine, Saint Louis University School of Medicine, St

Louis, MO, USA.

B-cell chronic lymphocytic leukemia has a highly variable clinical course with

behavior ranging from indolent to aggressive. Identified prognostic markers

include IgV(H) mutational status, and CD38 and ZAP-70 expression. In several

studies, ZAP-70 expression correlated with IgV(H) mutational status, and

predicted disease progression and overall survival. In addition to its

prognostic utility, ZAP-70 expression was found to be constant over time, and

did not vary between peripheral blood, bone marrow or lymph node specimens in

individual patients. In contrast to these reports, we present three CLL patients

with discordant ZAP-70 levels. One demonstrated a change in expression with

time; the second and third cases had discordant results in blood, lymph node and

bone marrow and between blood and bone marrow specimens, respectively, obtained

at the same time.

PMID: 18190465