Re: low fat diet/aspirin and cancer

[Guest guest]

I took aspirin for many years (>20) for joint pain, and today at 69yo, I quit taking even the 80 mg.

It causes bruising, the best I can describe it. Even 80 mg seems to weaken the skin, rubbing against a branch scrapes enough to show blood. Just leaning against a rough wall or floor, can cause the bruising. I'm still quite active in gardening, landscaping and one week I forgot to put the aspirin in the pill box. I noticed a change in less than a week, and now the effect has cleared up after just 2 weeks.

I'm toying with the idea of using it every other day.

It may have something to do with the other medications I take.

So did using aspirin for many years prevent colon cancer? I can say that it did just as accurately as assuming aspirin or a low fat diet "resists" cancer.

These articles favor low fat diet/aspirin:

Recent Results Cancer Res. 2005;166:47-61.

Preclinical models relevant to diet, exercise, and cancer risk.Barnard RJ, Aronson WJ.Departments of Physiological Science and Urology, University of California, Los Angeles, Los Angeles, CA 90095-1606, USA. jbarnard@...Metabolic syndrome was initially described as an aggregation of risk factors for the development of coronary artery disease with insulin resistance and compensatory hyperinsulinemia as the underlying factor. In an earlier review, we suggested that hyperinsulinemia may also lead to prostate cancer (PCa), the most common male cancer in industrialized nations. Furthermore, we suggested that diet and exercise, known to be important in the development of insulin resistance, may also be important in the development of PCa. When we placed men from the United States on a low-fat diet and/or exercise program, serum levels of insulin, free testosterone, estradiol and insulin-like growth factor (IGF)-1 were reduced while sex hormone-binding globulin (SHBG) and insulin-like growth factor binding protein (IGFBP)-1 were elevated. These in vivo serum changes directly impacted on androgen-dependent prostate cancer cell lines in vitro to reduce cell growth and induce apoptosis. The reduction in serum IGF-1 and increase in IGFBP-1 with diet and exercise appear to be the most significant, as these changes lead to an increase in tumor cell p53 protein and its down-stream effector p21, which are responsible for the reduction in cell growth and induced apoptosis. Preliminary results from a clinical study with men on "watchful waiting" indicate that the observed in vitro effects of diet and exercise on prostate cancer cell growth also occur in vivo. PMID: 15648182

Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1315-8.

Aspirin use and risk of biliary tract cancer: a population-based study in shanghai, china.Liu E, Sakoda LC, Gao YT, Rashid A, Shen MC, Wang BS, Deng J, Han TQ, Zhang BH, Fraumeni JF Jr, Hsing AW.Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7058, Bethesda, MD 20892-7234. hsinga@....The association of gallbladder and bile duct cancers with gallstones, cholecystitis, and cholangitis suggest that chronic inflammation contributes to the carcinogenic process. However, the effect of nonsteroidal anti-inflammatory drugs, such as aspirin, on biliary tract cancer has not been well studied. In a population-based case-control study conducted in Shanghai, China, we examined the relationship between aspirin use and the risk of biliary disease. A total of 627 patients with biliary tract cancer, including cancers of the gallbladder (n = 368), extrahepatic bile duct (n = 191), and ampulla of Vater (n = 68); 1,037 patients with biliary stones; and 958 healthy adults were included in the study. Self-reported data on aspirin use was collected from study participants by in-person interview. The prevalence of aspirin use was low, with 5.7% of the population controls being regular users. After controlling for age, sex, education, and biliary stone status, aspirin use was associated with a reduced risk of gallbladder cancer [odds ratio (OR), 0.37; 95% confidence interval (CI), 0.17-0.88]. An inverse relationship was also observed for frequency and duration of use and with younger age when starting use. In addition, there was a nonsignificant reduction in the risk of bile duct (OR, 0.48; 95% CI, 0.19-1.19) and ampullary cancers (OR, 0.22; 95% CI, 0.03-1.65) associated with aspirin use, whereas no clear association was seen with biliary stones (OR, 0.92; 95% CI, 0.59-1.44). Further studies of biliary tract cancer in other populations are needed to confirm these results and to elucidate the mechanisms that underlie the reduced risk associated with use of aspirin and possibly other nonsteroidal anti-inflammatory drugs. PMID: 15894693

Regards.

----- Original Message -----

From: oc9

Sent: Monday, May 16, 2005 8:19 PM

Subject: [ ] ASOC press release on breast cancer and diet, and colon cancer and aspirin

Here is the link to the file from the American Society of Clinical Oncologists that summarizes this finding (with slightly more details) along with a summary of one that refers to aspirin reducing the recurrence of colon cancer.http://www.asco.org/asco/downloads/final_survivorship_release_04.25.052.pdf(put the whole link in the URL window with no spaces in it, even if it breaks here and clicking on it doesn't work)Iris