Re: Re: JAMA: Coffeeprevents Type 2 Diabetes

[Guest guest]

You guys are a kick.

, we know your personality by now, but most probably don't understand the techs of your posts.

I think the reviewers wouldn't be able to do the silly analyses if they didn't drink a lot of coffee (ha).

IMO, most critiques of caffeine are religious inspired, ie, no basis. It's the "hazardous" chemicals (mercaptans, eg) that get a uneducated bad rap. "Hazardous" chem may kill cancers (just guessing).

What I look for is not the diabetes, et al risks, but the longevity.

Do I live longer if I drink coffee and/or tea and do I know it when I do.

Here's an unbiased study (ha)

J Clin Epidemiol. 1992 Jul;45(7):733-42.

Coffee consumption and cause-specific mortality. Association with age at death and compression of mortality.Lindsted KD, Kuzma JW, JL.Loma University, CA 92354.The relationship between reported coffee consumption and specific causes of death was examined in 9484 males enrolled in the Adventist Mortality Study in 1960 and followed through 1985. Coffee consumption was divided into three levels: less than 1 cup per day, 1-2 cups per day, and greater than or equal to 3 cups per day. Approximately one third of the subjects did not drink coffee. Cause-specific mortality rates were compared using survival analysis including 's proportional hazard model, and controlling for potential confounders such as body mass index, heart disease and hypertension at baseline, race, physical activity, marital status, educational level, smoking history, and dietary pattern. Inclusion of interaction terms between coffee consumption and attained age as time-dependent covariates allowed the hazard ratio to vary with age. Univariate analyses showed a statistically significant association (p less than 0.05) for coffee consumption and mortality for most endpoints. Multivariate analyses showed a small but statistically significant association between coffee consumption and mortality from ischemic heart disease, other cardiovascular diseases, all cardiovascular diseases, and all causes of death. For the major causes of death, the hazard ratios decreased from about 2.5 at 30 years of age to 1.0 around 95 years of age. These results indicate that abstinence from coffee leads to compression of mortality rather than an increase in lifespan. PMID: 1619453

LOOK at this "the hazard ratios decreased from about 2.5 at 30 years of age to 1.0 around 95 years of age."

I guess when I get to 95 I can drink all I want?

Regards.

----- Original Message -----

From: pct35768

Sent: Thursday, July 07, 2005 8:47 PM

Subject: [ ] Re: JAMA: Coffeeprevents Type 2 Diabetes

> Hi :> > Not sure what you are trying to tell me here.I hope you took the first line in my post as a "joke". I can't tell if I am rubbing people the wrong way in CyberLand. If you did take it as a joke, then your concerns are strictly philosophical, which means you are not angry (I hope). > > I have already posted that it appears there is about 60% LESS > diabetes in the UK - a predominantly tea drinking country - than > there is in the US - a mostly coffee-drinking country.> > So, the question remains, if coffee is good at least one piece of > evidence appears to suggest that it doesn't make a huge amount of > difference in comparison with tea.Okay, you are contending that tea is superior to coffee. I am not arguing with you, as you obviously have your convictions. All I was emphasizing is that regionalism is rampant in the scientific discourse.Given that source of "noise in the data", your observation that tea and health seem to be correlated in the United Kingdom. So, by extension, Americans should start clipping their vowels to increase the life of the their years? > > But of course there are other factors involved in diabetes incidence, > besides what kind of hot beverage a country drinks. Nevertheless, > the difference does seem to be HUGE, and certainly suggests the > influence of coffeee is relatively marginal.Yes, a multifactorial phenomenon is definitely afoot, love.> > Or do you have an alternative interpretation?Actually, I tend to agree that black tea is more "benign" than coffee. However, your logic is telling me that the blood pudding and scones are the ticket to supercentenarianville.http://en.wikipedia.org/wiki/Black_pudding T.pct35768@...

[Guest guest]

I've wondered why we brew coffee and especially tea.

Some PCa patients EAT the green tea. After all, if the brew is good the whole has to be better (?). They add it to stews, eg. When you have PCa I guess you try anything for alternative medicine.

I would think though that anyone who thinks tea is good should use the capsules, eg., but even those have been processed, so like the herbs I sometimes grow, the fresh leaves are much more potent. Try fresh basil in pesto, eg.

TOL, I could try green tea in a pesto.

As a spice, green tea is potent like your typical "Italian" spice, so I have to wonder if tea shouldn't be considered a spice.

If anyone wants to look at tea's contents:

http://www.ars-grin.gov/duke/index.html

This provides the chems and the activities.

http://www.ars-grin.gov/cgi-bin/duke/farmacy2.pl

If half this stuff is true, we would never be sick again. I would not have hypertension, eg.

There are many unknowns. Do we really want to use chemicals we know little about?

CATECHIN Leaf 85 - 12,700 ppm

ACE-Inhibitor 0.24 mg/ml rbt (weak activity) IC50=0.155 mM/l; Antiaggregant IC68=200 ug/ml; Anticoagulant; Anticomplementary 1/2 aspirin; AntiHIV EC50=4 ug/ml; Antiinflammatory IC50=40-943 uM (cf indomethacin IC50=1 uM); Antimutagenic ID50=50-100 nM; Antioxidant; Antiperoxidant; Antiprostaglandin IC50=40-943 uM (cf indomethacin IC50=1 uM); Antiradicular; Antiulcer; Beta-Adrenergic Receptor Blocker 10 uM (weak activity); cAMP-Phosphodiesterase-Inhibitor; Cancer-Preventive; Cardiotonic; COX-1-Inhibitor IC50=183-279 uM (cf indomethacin IC50=1 uM); COX-2-Inhibitor IC50=546-5,910 uM (cf indomethacin IC50=1 uM); Cyclooxygenase-Inhibitor; Cytotoxic TC50=>100 ug/ml; Dermatitigenic; Hemostat; Hepatoprotective; Immunostimulant; Phagocytotic; Vasoconstrictor; Xanthine-Oxidase-Inhibitor

1,3,5-TRIHYDROXY-BENZENE Leaf:

Prostaglandin-Synthesis-Inhibitor IC50=45 uM

4-TERPINEOL Leaf:

Antiasthmatic; Antioxidant; Diuretic; FLavor FEMA 20-100; Insectifuge; Perfumery; Pesticide {keeps you awake}

ADENINE Leaf:

Antianemic 1.5 g/day; Antigranulocytopenic; Antiviral; CNS-Stimulant; Diuretic; Hyperuricemic; Insectifuge; Lithogenic; Myocardiotonic; Pesticide; Vasodilator

ALANINE Plant:

Antioxidant; Cancer-Preventive; Oxidant

ALLANTOIN Plant:

Antidandruff; Antiinflammatory; Antioxidant; Antipeptic 30-130 mg/man/day; Antipsoriac 2%; Antiradicular; Antiulcer; Immunostimulant; Keratolytic; Sunscreen 0.1%; Suppurative; Vulnerary

ALPHA-AMYRIN Seed Oil:

Antiedemic IC43=40 mg/kg ipr rat; Antiinflammatory IC71=1,000 ppm orl; Antinociceptive; Antitumor; Cytotoxic 50-400; Insectifuge

ALUMINUM Leaf 690 ppm;

Antisilicotic; Antivaginitic; Candidicide; Encephalopathic; Pesticide

APIGENIN Leaf:

11B-HSD-Inhibitor; Antiaflatoxin IC50=2.57 ppm IC50=9.52 uM; Antiaggregant; Antiallergic; Antiangiogenic 4 uM; Antiarrhythmic; Antibacterial; Anticomplementary; Antidermatitic; Antiestrogenic; Antiherpetic 20-54 ug/ml; Antihistaminic IC50=10-35 uM; AntiHIV IC50=143 ug/ml IC72=200 ug/ml; Antiinflammatory = indomethacin IC~65=1,000 uM; Antileukemic 20-50 uM; Antimelanomic 1-50 uM; Antimetastatic; Antimutagenic ID50=10-40 nM; Antioxidant 1.5 x Vit. E IC28.5=62.5 ug/ml; Antiproliferant 1-50 uM; Antispasmodic EC50=1-5 uM; Antithyroid; Antitumor 1-50 uM; Antitumor (Breast); Antitumor (Lung); Antitumor (Skin); Antiviral 20-54 ug/ml; Anxiolytic 10 mg/kg; Apoptotic 12-60 uM; Aromatase-Inhibitor IC65=1 uM/l; Beta-Glucuronidase-Inhibitor IC50=~40 uM; Calcium-Antagonist?; Cancer-Preventive; Choleretic; CNS-Depressant; COX-1-Inhibitor IC65=1,000 uM; COX-2-Inhibitor <40 uM IC>65=1,000 uM; Cyclooxygenase-Inhibitor; Cytochrome-P450-1A1-Inhibitor; Cytotoxic 1-50 uM IC88=10 ug/ml; Deiodinase-Inhibitor; Differentiator IC40=40 uM MIC=30 uM; Diuretic; DNA-Protective; Estrogenic 16% genistein EC50=0.1-25 uM/l EC50=1 uM; Hyaluronidase-Inhibitor IC50+=50-250 uM; Hypotensive; Inotropic; MAO-Inhibitor; Musculotropic; Mutagenic; Myorelaxant; NADH-Oxidase-Inhibitor; NO-Synthase-Inhibitor 5-50 uM; Nodulation-Signal; Ornithine-Decarboxylase-Inhibitor; P21-Inducer 10-70 uM; Pesticide; PKC-Inhibitor IC50=10 uM; Polyamine-Synthesis-Inhibitor; Progestational; Protein-Kinase-C-Inhibitor IC50=10-40 uM; PTK-Inhibitor 10-100 uM; Quinone-Reductase-Inducer 20 uM; Radioprotective; Sedative 30-100 mg/kg; Sunscreen; Topoisomerase-I-Inhibitor; Topoisomerase-II-Inhibitor 50 ug/ml IC28=18 uM IC45=180 uM; Uterotrophic EC50=0.1-25 uM/l; Vasodilator

ASTRAGALIN Leaf:

ACE-Inhibitor ID50=180 ug/ml rat (24 hr.); Aldose-Reductase-Inhibitor IC30=1 uM IC62=10 uM; Antileukemic; Expectorant; Hypotensive; Immunostimulant

BENZOIC-ACID Leaf:

Allergenic; Anesthetic; Antibacterial 33-1,250 ppm MBC=800 ug/ml; Antiotitic; Antipyretic; Antisalmonella MIC=800 ug/ml; Antiseptic 800 ug/ml; Antiyeast MFC=1,600 ug/ml; Choleretic; Expectorant; FLavor FEMA 250; Fungicide MFC=1,600 ug/ml; Insectifuge; Pesticide; Phytoalexin; Tyrosinase-Inhibitor ID50=640 uM ID50=710 uM; Uricosuric; Vulnerary

BENZYL-ACETATE Leaf:

Acaricide; Cardiotonic; Emetic; FLavor FEMA 35-800; Hypotensive; Irritant; Laxative; Tumorigenic; Varroacide

CAFFEINE Leaf 3,810 - 93,000 ppm Shoot 38,100 - 47,900 ppm

(+)-Inotropic; Adenosine-Antagonist; Analeptic 200 scu mus; Analgesic-Synergist; Antiapneic; Antiapoptotic; Antiasthmatic 5-10 mg/kg orl/man; Anticarcinogenic; Anticariogenic; Antidermatitic; Antiemetic; Antifeedant; Antiflu; Antiherpetic; Antihypotensive 250 mg/day/orl/man; Antinarcotic; Antiobesity; Antioxidant; Antirhinitic 140 mg/day/orl/man; Antiserotonergic 40 ipr rat 40 scu rat; Antitumor; Antitumor (Lung); Antivaccinia; Antiviral; Apoptotic; Arrhythmigenic 1,500 mg/man; cAMP-Phosphodiesterase-Inhibitor; Cancer-Preventive; Cardiotonic 10-25 orl dog 65-500 orl cat; Catabolic; cGMP-Phosphodiesterase-Inhibitor; Choleretic; CNS-Stimulant 100 orl mus 30 orl rat; Coronary-Dilator; Diuretic; Energizer 20-200 mg/man; Ergotamine-Enhancer; FLavor FEMA 125; Herbicide; Hypertensive; Hypoglycemic; Insecticide; Lypolytic; Myorelaxant; Neurotoxic; Pesticide; Phosphodiesterase-Inhibitor; Pyrogenic 13.3 mg/kg ipr rbt 15 mg/kg ipr cat 60 mg/day oral hmn; Respirastimulant; Spasmogenic 1,500 mg/man; Stimulant; Tachycardic; Teratogenic 14 orl rat; Topoisomerase-I-Inhibitor 0.1 nM 75 uM; Topoisomerase-II-Inhibitor 99 mM; Vasodilator

CARVACROL Leaf:

Allergenic; Anesthetic; Anthelmintic; Antialzheimeran?; Antiatherosclerotic IC50=5.53 uM; Antibacterial MIC 170-290 MIC=39-625; Anticholinesterase?; Antidiuretic; Antiinflammatory IC50=4 uM; Antimelanomic IC50=120 uM/l; Antioxidant; Antioxidant (LDL) IC50=5.53 uM; Antiplaque MIC=39-625 ug/ml; Antiprostaglandin; Antiradicular 600 x thymol; Antiseptic 1.5 x phenol; Antispasmodic; Antistaphylococcic; Antistreptococcic; Antitussive; Candidicide 100-150 ug/ml MIC<0.1 ug/ml; Carminative; Cyclooxygenase-Inhibitor =indomethacin; Enterorelaxant; Expectorant; FLavor FEMA 10-125; Fungicide; Insectifuge; Irritant; Nematicide MLC=1 mg/ml; Pesticide; Prostaglandin-Inhibitor; Tracheorelaxant; Trichomonicide LD100=150 ug/ml; Vermifuge

CHLOROGENIC-ACID Leaf:

Aldose-Reductase-Inhibitor IC50=1.8 uM rat (strong activity); Allelochemic; Allergenic; Analgesic; Antiatherosclerotic; Antibacterial; Anticancer (Colon); Anticancer (Forestomach); Anticancer (Liver); Anticancer (Skin); Anticarcinogenic; AntiEBV; Antifeedant; Antigenotoxic; Antigonadotropic; Antihemolytic 10 uM; Antihepatotoxic; Antiherpetic; Antihistaminic; AntiHIV; Antihypercholesterolemic; Antihyperthyroid; Antiinflammatory; AntiLegionella; Antileukotriene; Antimelanogenic; Antimutagenic; Antinitrosaminic; Antioxidant IC53=200 ppm IC80=12 uM; Antiperoxidant IC50=36 uM; Antipolio; Antiradicular 10 uM 9 x quercetin; Antiseptic; Antisunburn; Antithyroid; Antitumor; Antitumor (Colon); Antitumor (Forestomach); Antitumor (Liver); Antitumor (Skin); Antitumor-Promoter IC25=10 uM; Antiulcer; Antiviral; Autotoxic; Cancer-Preventive; Cholagogue; Choleretic; Clastogenic; CNS-Active; CNS-Stimulant 1/6 Caffeine; Collagen-Sparing; Diuretic; Fungicide; Hepatoprotective; Histamine-Inhibitor; Immunostimulant; Insectifuge; Interferonogenic; Juvabional; Larvistat; Leukotriene-Inhibitor; Lipoxygenase-Inhibitor IC23=5 mM; Metal-Chelator; NO-Genic; Ornithine-Decarboxylase-Inhibitor; Oviposition-Stimulant; Pesticide; Sunscreen; Sweetener; Vulnerary

CINNAMIC-ACID Leaf:

Aldose-Reductase-Inhibitor 4 ug/ml (weak activity); Allergenic; Anesthetic; Antibacterial; Antiinflammatory; Antimutagenic; Antispasmodic; Cancer-Preventive; Choleretic; Dermatitigenic; FLavor FEMA 4-40; Fungicide; Herbicide; Laxative; Lipoxygenase-Inhibitor; Pesticide; Vermifuge

EPICATECHIN Leaf 149 - 21,250 ppm

Allelochemic IC100=1 mM; Antiaggregant IC94=200 ug/ml; Antianaphylactic; Antibacterial MIC=>1,000 ug/ml; Anticomplementary 1/2 aspirin; Antidiabetic 30 mg/kg rat; AntiEBV; Antihepatitic; AntiHIV EC50=2 ug/ml; Antihyperglycemic; Antiinflammatory; Antileukemic IC50=>10 ug/ml; Antilipoperoxidant; Antimutagenic; Antioxidant 2.5 x Vit. E IC50=6.3 ug/ml; Antiperoxidant; Antiviral; Cancer-Preventive; Cardiotonic; Choline-Sparing; Hepatotropic; Hypocholesterolemic; Hypoglycemic; Insulinogenic; Lipoxygenase-Inhibitor IC50=140 uM IC97=5 mM; Pancreatogenic; Peroxynitrite-Scavenger IC50=0.181 ug/ml; Pesticide; Propecic; Xanthine-Oxidase-Inhibitor IC50=>40

EPICATECHIN-GALLATE Leaf 5,417 - 31,000 ppm

Anticariogenic; Antihepatotoxic; Antimutagenic; Antioxidant >10 x tocopherol; Antiperoxidant; Cancer-Preventive; COMP-Inhibitor; Glucosyl-Transferase-Inhibitor; Immunostimulant; Lipoxygenase-Inhibitor IC50=18 uM; Mitogen; Xanthine-Oxidase-Inhibitor IC50=>40

EPIGALLOCATECHIN Leaf 862 - 31,000 ppm

Antimutagenic; Antioxidant IC50=1.4 ug/ml; Antiradicular; Beta-Adrenergic Receptor Blocker 10 uM; Lipoxygenase-Inhibitor IC50=21 uM; Xanthine-Oxidase-Inhibitor IC50=>40

EPIGALLOCATECHIN-3-O-GALLATE Leaf 7,140 - 8,718 ppm

Antiischemic; Antioxidant IC50=0.14 ug/ml; Antiretinopathic

FARNESOL Leaf:

Allergenic; Antiadenomic; Anticancer (Pancreas) IC50=39 uM; Anticarcinomic (Colon); Anticarcinomic (Lung); Antileukemic; Antimelanomic IC50=50 uM/l; Antispasmodic; Apoptotic; FLavor FEMA 0.1-3; Juvabional; Nematicide MLC=100 ug/ml; Perfumery; Pesticide; Pheromonal; Sedative; Trichomonicide LD100=100 ug/ml

GALLIC-ACID Leaf:

ACE-Inhibitor IC50=7.7 mM/l; Analgesic; Antiadenovirus; Antiallergenic; Antianaphylactic; Antiasthmatic; Antibacterial MIC=1,000 ug/ml; Antibronchitic; Anticancer; Anticarcinomic ED50=3; Antifibrinolytic; Antiflu; Antihepatotoxic; Antiherpetic EC50=>10 ug/ml; AntiHIV; Antiinflammatory; Antileishmanic EC50=4.4 ug/ml; Antimutagenic; Antinitrosaminic; Antioxidant 7 x quercetin IC44=33 ppm; Antiperoxidant IC50=69 uM; Antipolio; Antiradicular 7 x quercetin; Antiseptic; Antistaphylococcic MIC=1,000 ug/ml; Antitumor; Antitumor-Promoter; Antiviral; Apoptotic; Astringent; Bacteristat; Bronchodilator; Cancer-Preventive; Carcinogenic; Choleretic; Cyclooxygenase-Inhibitor; Floral-Inhibitor; Gram(+)icide; Gram(-)icide; Hemostat; Immunomodulator; Immunostimulant; Immunosuppressant; Insulin-Sparing; Myorelaxant; Nephrotoxic; Pesticide; Styptic; Topoisomerase-I-Inhibitor; Xanthine-Oxidase-Inhibitor IC50=24 uM

GERANIOL Leaf 2 - 2,546 ppm Shoot 800 - 1,200 ppm

Allergenic; Anthelmintic; Antibacterial MBC=800 ug/ml MIC=400 ug/ml MIC=64 ug/ml; Anticancer (Pancreas) IC50=265 uM; Anticariogenic MIC=400 ug/ml; Antimelanomic IC50=150 uM/l; Antisalmonella MIC=400 ug/ml; Antiseptic 400-800 ug/ml 7 x phenol MIC=64 ug/ml; Antispasmodic; Antitubercular; Antitumor; Antitumor (Pancreas) IC50=265 uM; Ascaricide; Cancer-Preventive; Candidicide; CNS-Stimulant; Embryotoxic; Emetic 3 x ipecac; Expectorant; FLavor FEMA 1-10; Fungicide IC93=2 mM; Herbicide IC100-2,000 uM; Insectifuge 50 ppm; Insectiphile; Mycobactericide MIC=64 ug/ml; Nematicide IC86=100 ug/ml MLC=1,000 ug/ml; Perfumery; Pesticide; Sedative; Trichomonicide LD100=300 ug/ml

Enough. This isn't the whole list.

Regards.

----- Original Message -----

From: Gay e

Sent: Friday, July 08, 2005 9:36 AM

Subject: [ ] Re: JAMA: Coffeeprevents Type 2 Diabetes

Just a quick comment from the UK, a little annecdotal I suppose.Blood sausage (black pudding) is disliked by many nowadays, perhaps not as popular as it once was, and scones and clotted cream are lovely when visiting Devon or Cornwall but most of us wouldn't do that often. Scones can be bought in the supermarket but frankly, are probably not as bad as some of the other 'cake' options, not that I would buy them.Coffee tends to be more popular among the younger generation whereas as the older generation are probably more likely to have a cuppa eg my Mom and Dad drank tea, I drank coffee but have now switched to green tea. A lot of people my age, 53, and younger will perhaps not be the avid tea drinkers their parents were!Maybe more relevant, is the point about access to free healthcare. If you go to your GP at the drop of a hat and he suggests getting a bit of weight off, something is bound to rub off on some of us in time <grin>. We tend to think not enough people take dietary advice (maybe just as well in some cases) but there will always be a proportion that cut back on fat, salt or whatever. It surely has to affect the figures?Gay

[Guest guest]

If you choose Matcha Green Tea, you do actually eat, as well as drink it.

On 7/8/05, jwwright <jwwright@...> wrote:

> I've wondered why we brew coffee and especially tea.

> Some PCa patients EAT the green tea. After all, if the brew is good the

> whole has to be better (?).....

[Guest guest]

I don't know what types the green teas are I've tried but they were all palatable after running thru the coffee maker. Didn't do too well in a stew - just different.

When I did a survey of the chemicals in herbs a cupla years ago, I decided someone had picked the most useful already, like tomatoes, carrots, broccoli, prunes, papaya, but of course I only got thru the C's in the chemicals.

When I take the defined "good" chemical in Duke's into Medline, there's not a lot of info. I need access to an additional data source (without signing up for a Chinese, or other, herbal cure degree).

Regards.

----- Original Message -----

From: Dowling

Sent: Friday, July 08, 2005 11:01 AM

Subject: Re: [ ] Re: JAMA: Coffeeprevents Type 2 Diabetes

If you choose Matcha Green Tea, you do actually eat, as well as drink it.On 7/8/05, jwwright <jwwright@...> wrote:> I've wondered why we brew coffee and especially tea.> Some PCa patients EAT the green tea. After all, if the brew is good the> whole has to be better (?).....

[Guest guest]

Hi All,

Rodney, you seem to base the value of a complex food based on small amounts of

possibly harmful ingredients. There are many precious babies thrown out with

you

bathwaters?

--- Rodney <perspect1111@...> wrote:

> Hi JW:

>

> The same arguments can (and should?) be made about all foods. For

> example, most agree that fish is net beneficial, but the fatty fish

> (and the fish oils that come in capsules) all contain some myristic

> acid, which most observers believe to be harmful.

>

> In a hundred years I do not doubt we will have fish in the stores

> that have been bred/gene-spliced so that the myristic is eliminated.

>

> Rodney.

>

>

> > I've wondered why we brew coffee and especially tea.

> > Some PCa patients EAT the green tea. After all, if the brew is good

> the whole has to be better (?). They add it to stews, eg. When you

> have PCa I guess you try anything for alternative medicine.

> > I would think though that anyone who thinks tea is good should use

> the capsules, eg., but even those have been processed, so like the

> herbs I sometimes grow, the fresh leaves are much more potent. Try

> fresh basil in pesto, eg.

> > TOL, I could try green tea in a pesto.

> > As a spice, green tea is potent like your typical " Italian " spice,

> so I have to wonder if tea shouldn't be considered a spice.

> >

> > If anyone wants to look at tea's contents:

> > http://www.ars-grin.gov/duke/index.html

> > This provides the chems and the activities.

> > http://www.ars-grin.gov/cgi-bin/duke/farmacy2.pl

> > If half this stuff is true, we would never be sick again. I would

> not have hypertension, eg.

> > There are many unknowns. Do we really want to use chemicals we know

> little about?

> >

> > CATECHIN Leaf 85 - 12,700 ppm

> > ACE-Inhibitor 0.24 mg/ml rbt (weak activity) IC50=0.155 mM/l;

> Antiaggregant IC68=200 ug/ml; Anticoagulant; Anticomplementary 1/2

> aspirin; AntiHIV EC50=4 ug/ml; Antiinflammatory IC50=40-943 uM (cf

> indomethacin IC50=1 uM); Antimutagenic ID50=50-100 nM; Antioxidant;

> Antiperoxidant; Antiprostaglandin IC50=40-943 uM (cf indomethacin

> IC50=1 uM); Antiradicular; Antiulcer; Beta-Adrenergic Receptor

> Blocker 10 uM (weak activity); cAMP-Phosphodiesterase-Inhibitor;

> Cancer-Preventive; Cardiotonic; COX-1-Inhibitor IC50=183-279 uM (cf

> indomethacin IC50=1 uM); COX-2-Inhibitor IC50=546-5,910 uM (cf

> indomethacin IC50=1 uM); Cyclooxygenase-Inhibitor; Cytotoxic

> TC50=>100 ug/ml; Dermatitigenic; Hemostat; Hepatoprotective;

> Immunostimulant; Phagocytotic; Vasoconstrictor; Xanthine-Oxidase-

> Inhibitor

> > 1,3,5-TRIHYDROXY-BENZENE Leaf:

> > Prostaglandin-Synthesis-Inhibitor IC50=45 uM

> > 4-TERPINEOL Leaf:

> > Antiasthmatic; Antioxidant; Diuretic; FLavor FEMA 20-100;

> Insectifuge; Perfumery; Pesticide {keeps you awake}

> > ADENINE Leaf:

> > Antianemic 1.5 g/day; Antigranulocytopenic; Antiviral; CNS-

> Stimulant; Diuretic; Hyperuricemic; Insectifuge; Lithogenic;

> Myocardiotonic; Pesticide; Vasodilator

> > ALANINE Plant:

> > Antioxidant; Cancer-Preventive; Oxidant

> > ALLANTOIN Plant:

> > Antidandruff; Antiinflammatory; Antioxidant; Antipeptic 30-130

> mg/man/day; Antipsoriac 2%; Antiradicular; Antiulcer;

> Immunostimulant; Keratolytic; Sunscreen 0.1%; Suppurative; Vulnerary

> > ALPHA-AMYRIN Seed Oil:

> > Antiedemic IC43=40 mg/kg ipr rat; Antiinflammatory IC71=1,000 ppm

> orl; Antinociceptive; Antitumor; Cytotoxic 50-400; Insectifuge

> > ALUMINUM Leaf 690 ppm;

> > Antisilicotic; Antivaginitic; Candidicide; Encephalopathic;

> Pesticide

> > APIGENIN Leaf:

> > 11B-HSD-Inhibitor; Antiaflatoxin IC50=2.57 ppm IC50=9.52 uM;

> Antiaggregant; Antiallergic; Antiangiogenic 4 uM; Antiarrhythmic;

> Antibacterial; Anticomplementary; Antidermatitic; Antiestrogenic;

> Antiherpetic 20-54 ug/ml; Antihistaminic IC50=10-35 uM; AntiHIV

> IC50=143 ug/ml IC72=200 ug/ml; Antiinflammatory = indomethacin

> IC~65=1,000 uM; Antileukemic 20-50 uM; Antimelanomic 1-50 uM;

> Antimetastatic; Antimutagenic ID50=10-40 nM; Antioxidant 1.5 x Vit. E

> IC28.5=62.5 ug/ml; Antiproliferant 1-50 uM; Antispasmodic EC50=1-5

> uM; Antithyroid; Antitumor 1-50 uM; Antitumor (Breast); Antitumor

> (Lung); Antitumor (Skin); Antiviral 20-54 ug/ml; Anxiolytic 10 mg/kg;

> Apoptotic 12-60 uM; Aromatase-Inhibitor IC65=1 uM/l; Beta-

> Glucuronidase-Inhibitor IC50=~40 uM; Calcium-Antagonist?; Cancer-

> Preventive; Choleretic; CNS-Depressant; COX-1-Inhibitor IC65=1,000

> uM; COX-2-Inhibitor <40 uM IC>65=1,000 uM; Cyclooxygenase-Inhibitor;

> Cytochrome-P450-1A1-Inhibitor; Cytotoxic 1-50 uM IC88=10 ug/ml;

> Deiodinase-Inhibitor; Differentiator IC40=40 uM MIC=30 uM; Diuretic;

> DNA-Protective; Estrogenic 16% genistein EC50=0.1-25 uM/l EC50=1 uM;

> Hyaluronidase-Inhibitor IC50+=50-250 uM; Hypotensive; Inotropic; MAO-

> Inhibitor; Musculotropic; Mutagenic; Myorelaxant; NADH-Oxidase-

> Inhibitor; NO-Synthase-Inhibitor 5-50 uM; Nodulation-Signal;

> Ornithine-Decarboxylase-Inhibitor; P21-Inducer 10-70 uM; Pesticide;

> PKC-Inhibitor IC50=10 uM; Polyamine-Synthesis-Inhibitor;

> Progestational; Protein-Kinase-C-Inhibitor IC50=10-40 uM; PTK-

> Inhibitor 10-100 uM; Quinone-Reductase-Inducer 20 uM;

> Radioprotective; Sedative 30-100 mg/kg; Sunscreen; Topoisomerase-I-

> Inhibitor; Topoisomerase-II-Inhibitor 50 ug/ml IC28=18 uM IC45=180

> uM; Uterotrophic EC50=0.1-25 uM/l; Vasodilator

> > ASTRAGALIN Leaf:

> >

> > ACE-Inhibitor ID50=180 ug/ml rat (24 hr.); Aldose-Reductase-

> Inhibitor IC30=1 uM IC62=10 uM; Antileukemic; Expectorant;

> Hypotensive; Immunostimulant

> >

> > BENZOIC-ACID Leaf:

> >

> > Allergenic; Anesthetic; Antibacterial 33-1,250 ppm MBC=800 ug/ml;

> Antiotitic; Antipyretic; Antisalmonella MIC=800 ug/ml; Antiseptic 800

> ug/ml; Antiyeast MFC=1,600 ug/ml; Choleretic; Expectorant; FLavor

> FEMA 250; Fungicide MFC=1,600 ug/ml; Insectifuge; Pesticide;

> Phytoalexin; Tyrosinase-Inhibitor ID50=640 uM ID50=710 uM;

> Uricosuric; Vulnerary

> >

> > BENZYL-ACETATE Leaf:

> >

> > Acaricide; Cardiotonic; Emetic; FLavor FEMA 35-800; Hypotensive;

> Irritant; Laxative; Tumorigenic; Varroacide

> > CAFFEINE Leaf 3,810 - 93,000 ppm Shoot 38,100 - 47,900 ppm

> >

> > (+)-Inotropic; Adenosine-Antagonist; Analeptic 200 scu mus;

> Analgesic-Synergist; Antiapneic; Antiapoptotic; Antiasthmatic 5-10

> mg/kg orl/man; Anticarcinogenic; Anticariogenic; Antidermatitic;

> Antiemetic; Antifeedant; Antiflu; Antiherpetic; Antihypotensive 250

> mg/day/orl/man; Antinarcotic; Antiobesity; Antioxidant; Antirhinitic

> 140 mg/day/orl/man; Antiserotonergic 40 ipr rat 40 scu rat;

> Antitumor; Antitumor (Lung); Antivaccinia; Antiviral; Apoptotic;

> Arrhythmigenic 1,500 mg/man; cAMP-Phosphodiesterase-Inhibitor; Cancer-

> Preventive; Cardiotonic 10-25 orl dog 65-500 orl cat; Catabolic; cGMP-

> Phosphodiesterase-Inhibitor; Choleretic; CNS-Stimulant 100 orl mus 30

> orl rat; Coronary-Dilator; Diuretic; Energizer 20-200 mg/man;

> Ergotamine-Enhancer; FLavor FEMA 125; Herbicide; Hypertensive;

> Hypoglycemic; Insecticide; Lypolytic; Myorelaxant; Neurotoxic;

> Pesticide; Phosphodiesterase-Inhibitor; Pyrogenic 13.3 mg/kg ipr rbt

> 15 mg/kg ipr cat 60 mg/day oral hmn; Respirastimulant; Spasmogenic

> 1,500 mg/man; Stimulant; Tachycardic; Teratogenic 14 orl rat;

> Topoisomerase-I-Inhibitor 0.1 nM 75 uM; Topoisomerase-II-Inhibitor 99

> mM; Vasodilator

> > CARVACROL Leaf:

> > Allergenic; Anesthetic; Anthelmintic; Antialzheimeran?;

> Antiatherosclerotic IC50=5.53 uM; Antibacterial MIC 170-290 MIC=39-

> 625; Anticholinesterase?; Antidiuretic; Antiinflammatory IC50=4 uM;

> Antimelanomic IC50=120 uM/l; Antioxidant; Antioxidant (LDL) IC50=5.53

> uM; Antiplaque MIC=39-625 ug/ml; Antiprostaglandin; Antiradicular 600

> x thymol; Antiseptic 1.5 x phenol; Antispasmodic; Antistaphylococcic;

> Antistreptococcic; Antitussive; Candidicide 100-150 ug/ml MIC<0.1

> ug/ml; Carminative; Cyclooxygenase-Inhibitor =indomethacin;

> Enterorelaxant; Expectorant; FLavor FEMA 10-125; Fungicide;

> Insectifuge; Irritant; Nematicide MLC=1 mg/ml; Pesticide;

> Prostaglandin-Inhibitor; Tracheorelaxant; Trichomonicide LD100=150

> ug/ml; Vermifuge

> > CHLOROGENIC-ACID Leaf:

> > Aldose-Reductase-Inhibitor IC50=1.8 uM rat (strong activity);

> Allelochemic; Allergenic; Analgesic; Antiatherosclerotic;

> Antibacterial; Anticancer (Colon); Anticancer (Forestomach);

> Anticancer (Liver); Anticancer (Skin); Anticarcinogenic; AntiEBV;

> Antifeedant; Antigenotoxic; Antigonadotropic; Antihemolytic 10 uM;

> Antihepatotoxic; Antiherpetic; Antihistaminic; AntiHIV;

> Antihypercholesterolemic; Antihyperthyroid; Antiinflammatory;

> AntiLegionella; Antileukotriene; Antimelanogenic; Antimutagenic;

> Antinitrosaminic; Antioxidant IC53=200 ppm IC80=12 uM; Antiperoxidant

> IC50=36 uM; Antipolio; Antiradicular 10 uM 9 x quercetin; Antiseptic;

> Antisunburn; Antithyroid; Antitumor; Antitumor (Colon); Antitumor

> (Forestomach); Antitumor (Liver); Antitumor (Skin); Antitumor-

> Promoter IC25=10 uM; Antiulcer; Antiviral; Autotoxic; Cancer-

> Preventive; Cholagogue; Choleretic; Clastogenic; CNS-Active; CNS-

> Stimulant 1/6 Caffeine; Collagen-Sparing; Diuretic; Fungicide;

> Hepatoprotective; Histamine-Inhibitor; Immunostimulant; Insectifuge;

> Interferonogenic; Juvabional; Larvistat; Leukotriene-Inhibitor;

> Lipoxygenase-Inhibitor IC23=5 mM; Metal-Chelator; NO-Genic; Ornithine-

> Decarboxylase-Inhibitor; Oviposition-Stimulant; Pesticide; Sunscreen;

> Sweetener; Vulnerary

> > CINNAMIC-ACID Leaf:

> >

> > Aldose-Reductase-Inhibitor 4 ug/ml (weak activity); Allergenic;

> Anesthetic; Antibacterial; Antiinflammatory; Antimutagenic;

> Antispasmodic; Cancer-Preventive; Choleretic; Dermatitigenic; FLavor

> FEMA 4-40; Fungicide; Herbicide; Laxative; Lipoxygenase-Inhibitor;

> Pesticide; Vermifuge

> > EPICATECHIN Leaf 149 - 21,250 ppm

> > Allelochemic IC100=1 mM; Antiaggregant IC94=200 ug/ml;

> Antianaphylactic; Antibacterial MIC=>1,000 ug/ml; Anticomplementary

> 1/2 aspirin; Antidiabetic 30 mg/kg rat; AntiEBV; Antihepatitic;

> AntiHIV EC50=2 ug/ml; Antihyperglycemic; Antiinflammatory;

> Antileukemic IC50=>10 ug/ml; Antilipoperoxidant; Antimutagenic;

> Antioxidant 2.5 x Vit. E IC50=6.3 ug/ml; Antiperoxidant; Antiviral;

> Cancer-Preventive; Cardiotonic; Choline-Sparing; Hepatotropic;

> Hypocholesterolemic; Hypoglycemic; Insulinogenic; Lipoxygenase-

> Inhibitor IC50=140 uM IC97=5 mM; Pancreatogenic; Peroxynitrite-

> Scavenger IC50=0.181 ug/ml; Pesticide; Propecic; Xanthine-Oxidase-

> Inhibitor IC50=>40

> > EPICATECHIN-GALLATE Leaf 5,417 - 31,000 ppm

> > Anticariogenic; Antihepatotoxic; Antimutagenic; Antioxidant >10 x

> tocopherol; Antiperoxidant; Cancer-Preventive; COMP-Inhibitor;

> Glucosyl-Transferase-Inhibitor; Immunostimulant; Lipoxygenase-

> Inhibitor IC50=18 uM; Mitogen; Xanthine-Oxidase-Inhibitor IC50=>40

> > EPIGALLOCATECHIN Leaf 862 - 31,000 ppm

> > Antimutagenic; Antioxidant IC50=1.4 ug/ml; Antiradicular; Beta-

> Adrenergic Receptor Blocker 10 uM; Lipoxygenase-Inhibitor IC50=21 uM;

> Xanthine-Oxidase-Inhibitor IC50=>40

> > EPIGALLOCATECHIN-3-O-GALLATE Leaf 7,140 - 8,718 ppm

> > Antiischemic; Antioxidant IC50=0.14 ug/ml; Antiretinopathic

> > FARNESOL Leaf:

> > Allergenic; Antiadenomic; Anticancer (Pancreas) IC50=39 uM;

> Anticarcinomic (Colon); Anticarcinomic (Lung); Antileukemic;

> Antimelanomic IC50=50 uM/l; Antispasmodic; Apoptotic; FLavor FEMA 0.1-

> 3; Juvabional; Nematicide MLC=100 ug/ml; Perfumery; Pesticide;

> Pheromonal; Sedative; Trichomonicide LD100=100 ug/ml

> > GALLIC-ACID Leaf:

> > ACE-Inhibitor IC50=7.7 mM/l; Analgesic; Antiadenovirus;

> Antiallergenic; Antianaphylactic; Antiasthmatic; Antibacterial

> MIC=1,000 ug/ml; Antibronchitic; Anticancer; Anticarcinomic ED50=3;

> Antifibrinolytic; Antiflu; Antihepatotoxic; Antiherpetic EC50=>10

> ug/ml; AntiHIV; Antiinflammatory; Antileishmanic EC50=4.4 ug/ml;

> Antimutagenic; Antinitrosaminic; Antioxidant 7 x quercetin IC44=33

> ppm; Antiperoxidant IC50=69 uM; Antipolio; Antiradicular 7 x

> quercetin; Antiseptic; Antistaphylococcic MIC=1,000 ug/ml; Antitumor;

> Antitumor-Promoter; Antiviral; Apoptotic; Astringent; Bacteristat;

> Bronchodilator; Cancer-Preventive; Carcinogenic; Choleretic;

> Cyclooxygenase-Inhibitor; Floral-Inhibitor; Gram(+)icide; Gram(-)

> icide; Hemostat; Immunomodulator; Immunostimulant; Immunosuppressant;

> Insulin-Sparing; Myorelaxant; Nephrotoxic; Pesticide; Styptic;

> Topoisomerase-I-Inhibitor; Xanthine-Oxidase-Inhibitor IC50=24 uM

> > GERANIOL Leaf 2 - 2,546 ppm Shoot 800 - 1,200 ppm

> > Allergenic; Anthelmintic; Antibacterial MBC=800 ug/ml MIC=400 ug/ml

> MIC=64 ug/ml; Anticancer (Pancreas) IC50=265 uM; Anticariogenic

> MIC=400 ug/ml; Antimelanomic IC50=150 uM/l; Antisalmonella MIC=400

> ug/ml; Antiseptic 400-800 ug/ml 7 x phenol MIC=64 ug/ml;

> Antispasmodic; Antitubercular; Antitumor; Antitumor (Pancreas)

> IC50=265 uM; Ascaricide; Cancer-Preventive; Candidicide; CNS-

> Stimulant; Embryotoxic; Emetic 3 x ipecac; Expectorant; FLavor FEMA 1-

> 10; Fungicide IC93=2 mM; Herbicide IC100-2,000 uM; Insectifuge 50

> ppm; Insectiphile; Mycobactericide MIC=64 ug/ml; Nematicide IC86=100

> ug/ml MLC=1,000 ug/ml; Perfumery; Pesticide; Sedative; Trichomonicide

> LD100=300 ug/ml

> >

> > Enough. This isn't the whole list.

> >

> > Regards.

> >

> >

> > ----- Original Message -----

> > From: Gay e

> >

> > Sent: Friday, July 08, 2005 9:36 AM

> > Subject: [ ] Re: JAMA: Coffeeprevents Type 2 Diabetes

> >

> >

> > Just a quick comment from the UK, a little annecdotal I suppose.

> >

> > Blood sausage (black pudding) is disliked by many nowadays,

> perhaps

> > not as popular as it once was, and scones and clotted cream are

> > lovely when visiting Devon or Cornwall but most of us wouldn't do

> > that often. Scones can be bought in the supermarket but frankly,

> > are probably not as bad as some of the other 'cake' options, not

> > that I would buy them.

> >

> > Coffee tends to be more popular among the younger generation

> whereas

> > as the older generation are probably more likely to have a cuppa

> eg

> > my Mom and Dad drank tea, I drank coffee but have now switched to

> > green tea. A lot of people my age, 53, and younger will perhaps

> not

> > be the avid tea drinkers their parents were!

> >

> > Maybe more relevant, is the point about access to free

> healthcare.

> > If you go to your GP at the drop of a hat and he suggests getting

> a

> > bit of weight off, something is bound to rub off on some of us in

> > time <grin>. We tend to think not enough people take dietary

> advice

> > (maybe just as well in some cases) but there will always be a

> > proportion that cut back on fat, salt or whatever. It surely has

> to

> > affect the figures?

> >

> > Gay

>

>

>

Al Pater, PhD; email: old542000@...

____________________________________________________

Sell on Auctions – no fees. Bid on great items.

http://auctions./

[Guest guest]

Thanks, Alan,

Looks favorable for coffee. I didn't believe the 2.5 risk. Notice that study was 1 to 3 cups of coffee (snicker).

Makes no diff - I'm saturated with coffee since pre-teens.

I drank tea for many years also, but I notice green tea, which I also like, seems to keep me awake (alert).

Regards.

----- Original Message -----

From: Al Pater

Sent: Friday, July 08, 2005 3:54 PM

Subject: Re: [ ] Re: JAMA: Coffeeprevents Type 2 Diabetes

Hi All,Recent studies certainly are not consistent with your evidence.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15038588 & query_hl=17http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=11112231 & query_hl=17The last is pdf-available.--- jwwright <jwwright@...> wrote:> What I look for is not the diabetes, et al risks, but the longevity.> Do I live longer if I drink coffee and/or tea and do I know it when I do.> > Here's an unbiased study (ha)> > J Clin Epidemiol. 1992 Jul;45(7):733-42. > >

Coffee consumption was divided into three levels: less than> 1 cup per day, 1-2 cups per day, and greater than or equal to 3 cups per day.

[Guest guest]

I wouldn't rule out peanuts, because Aflatoxin is tested, but I wonder how many other things it might be on since I'm no expert at seeing it on foods.

Granted people have eaten a lot of peanuts, but corn also has to be tested. The afla grows more in the south and that may be part of the latitude effect in things like PCa. Might be the increase in aged folks is due to afla control?

One reason I don't order stuff thru the mail, especially from other countries.

I think there might be some testing for stuff I buy in the store.

Leaves for tea are commonly "oxidized" and I read where the African weeds were inspected, but oriental green tea seems a safer bet? Coffee is beans and that implies to me they are clean and cleaner by processing.

Anyway, I like coffee but I drink tea too. The chems in tea appear totally diff from coffee. I don't see the biomechanism for coffee "preventing" type 2.

Regards.

----- Original Message -----

From: Rodney

Sent: Friday, July 08, 2005 6:23 PM

Subject: [ ] Re: JAMA: Coffeeprevents Type 2 Diabetes

Hi Al:I hope not! I eat some high fat fish almost every day. But it would be even nicer to be able to eat fish without the myristic. As for the coffee, should I be drinking both coffee and tea? Maybe the answer will be found to be "Yes", but until we see that answer I have made the choice to use predominantly tea. (I drink coffee when out of the house because I do not like the way most people prepare tea.) Fruits usually contain a fair amount of sugar, but I eat fruit anyway, although I do not personally buy the fruits with the lower micronutrient/calories ratios - most notably apples. I sometimes eat peanuts (despite the aflatoxin risk) and more often other nuts despite the fat content. Indeed I have even been known occasionally to eat foods that contain dreaded calories ;; ^ ))) <<< that's a wink!If you are aware of any other babies I may be discarding with the bathwater, please let me know. If convinced I will change pretty much anything about my diet - although I am finding it difficult to reduce my starch intake. And I am only fairly strict about anything from Monday to Friday. Without, of course, going out of my way to eat poor food, I will eat pretty much whatever turns up Saturday and Sunday. Rodney.