Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk.

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BlankCommon genetic variation at 15q25.2 impacts on chronic lymphocytic

leukaemia risk.

D Crowther-Swanepoel, MC Di Bernardo, K Jamroziak, L Karabon, I Frydecka, S

Deaglio, G D'Arena, D Rossi, G Gaidano, B Olver, A Lloyd, P Broderick, L

ti, Z Szemraj-Rogucka, T Robak, D Catovsky, and RS Houlston

Br J Haematol, May 9, 2011; .

Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK

Department of Haematology, Copernicus Memorial Hospital, Medical University of

Lodz, Lodz Institute of Immunology and Experimental Therapy, Polish Academy of

Science, Wroclaw, Poland Department of Genetics, Biology and Biochemistry,

University of Turin and Human Genetics Foundation (HuGeF), Turin IRCCS 'Casa

Sollievo della Sofferenza' Hospital, San Giovanni Rotondo Division of

Haematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo

Avogadro University of Eastern Piedmont, Novara Catholic University of the

Sacred Heart, Institute of Haematology, Rome, Italy Section of Haemato-oncology,

Institute of Cancer Research, Sutton, Surrey, UK.

A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested

that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence

CLL. To validate these associations and explore their relationship with CLL risk

we genotyped case-control datasets from Poland, UK and Italy totalling 1428

cases and 1920 controls. Combined data from these and previously genotyped

series (2503 cases and 5789 controls) provided evidence for an association

between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) ?=?1?10???10(-7) and

1?30???10(-5) respectively). These data provide further evidence for the

involvement of common genetic variants in CLL risk and insight into the

biological basis of disease development.

PMID: 21554262