Clinical REPORT on CT-011

[Guest guest]

CT-011 is an investigational antibody that targets PD receptors on tumor

cells, thought to act as a brake against the immune response.

Here's a very easy-to-understand animation by the sponsor describing how

CT-011 is thought to work:

http://bit.ly/jWVQ8S

More info and Links to CT-011 studies:

http://www.lymphomation.org/treatment-pipeline.htm#pd1

(One study is evaluating CT-011 with Rituxan)

Finally a clinical report on CT-011:

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CureTech reports success in Phase II lymphoma trial

(As always, media releases should be interpreted with caution. As noted in

the report, a controlled study will be needed to validate the results of the

study, which compared outcomes to historical controls.)

Snips:

The trial achieved it primary endpoint of improved progression-free

survival, and its secondary endpoint of overall survival.

The trial included 72 patients with aggressive lymphoma at 30 centers in the

US, Asia, South America and Israel. 70% of the patients had no progression

in the disease at the end of the follow-up period, compared with 47% in the

historical control.

84% of patients were alive at the end of the follow-up period, compared with

62% in the historical control.

The final results are due in the third quarter, and will be presented at

international scientific meetings.

CureTech CEO Dr. Schickler said, " We are very pleased to have

achieved this major milestone in the clinical development of CT-011.

" Following the final results, CureTech will be ready to commence Phase III

regulatory studies for the high unmet need in this severe indication. "

....

More than 400 patients have participated in seven phase II and Phase I/II

studies with CT-011 for different cancers, including colon cancer, multiple

myeloma, acute leukemia, and pancreatic cancer.

CureTech has submitted a protocol to the US Food and Drug Administration

(FDA) for a Phase II trial for metastatic melanoma, a severe solid tumor

indication with very few treatment options.

All the best,

~ Karl

Patients Against Lymphoma

Patients Helping Patients

Non-profit | Independent | Evidence-based

www.lymphomation.org | Current News: http://bit.ly/f2A0T

How to Help: www.lymphomation.org/how-to-help.htm