A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.

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A genome-wide association study identifies six susceptibility loci for chronic

lymphocytic leukemia.

Chiara Di Bernardo, Dalemari Crowther-Swanepoel, Broderick,

Webb, le Sellick, Ruth Wild, Kate Sullivan, Jayaram Vijayakrishnan, Yufei

Wang, Alan M Pittman, Nicola J Sunter, G Hall, J S Dyer, Estella

Matutes, Dearden, Tryfonia Mainou-Fowler, Graham H , Geoffrey

Summerfield, J , R Pettitt, Hillmen, J Allsup,

R , Guy Pratt, Pepper, Fegan, M Allan,

Catovsky, and S Houlston

Nat Genet, August 31, 2008; .

[1] Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2

5NG. UK. [2] These authors contributed equally to this work.

We conducted a genome-wide association study of 299,983 tagging SNPs for chronic

lymphocytic leukemia (CLL) and performed validation in two additional series

totaling 1,529 cases and 3,115 controls. We identified six previously unreported

CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985,

SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1

(rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and

19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first

evidence for the existence of common, low-penetrance susceptibility to a

hematological malignancy and new insights into disease causation in CLL.

PMID: 18758461