Guest guest Posted July 28, 2005 Report Share Posted July 28, 2005 Does this mean that we have been depriving ourselves for nothing? Maybe not. At least we are decreasing our chances of CVD and diabetes. BUT this may mean that extreme dietary restriction may not pay off in extra longevity. This is another argument in favor of moderation. Tony --- In , Al Pater <old542000@y...> wrote: > Hi All, > > Will there be no CR in humans? > > See the not pdf-available Medline citation and abstract below (1). > > Rose, RM had previously written the below (2), with the additional reply (3). > > 1. Phelan JP, Rose MR. > Why dietary restriction substantially increases longevity in animal models but won't > in humans. > Ageing Res Rev. 2005 Jul 23; [Epub ahead of print] > PMID: 16046282 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 2005 Report Share Posted July 28, 2005 >>Does this mean that we have been depriving ourselves for nothing? Maybe not. At least we are decreasing our chances of CVD and diabetes. BUT this may mean that extreme dietary restriction may not pay off in extra longevity. As you said, I never view living responsibly to be able to live as free of disease as possible, and trying to maximize my potential, regardless of whether or not I extend the potential, as " nothing " Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 2005 Report Share Posted July 28, 2005 >Consequently, we develop a hypothesis-neutral model describing the relationship between >diet and longevity. Whenever an individual, or a pair of individuals, says they have a "model" that explains everything, you should bid them a good day, and walk as quickly as possible in the opposite direction. I bet this whole thing is a statistical mush resulting from the "garbage in, garbage out" mentality of many who like to play around with actuarial data. Having said, they could end up being right, but it is not going to be for the reasons they think. For instance, I have not seen any data confirming any sort of definitive relationship between reproduction and lifespan in humans. This is apparently an important consideration for their highly-speculative model. T. pct35768@... .. __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 2005 Report Share Posted July 28, 2005 Hi everyone, A number of us have run the numbers and come up with 8 years as about as long as CR "might" extend life and that only if everything goes perfect. CR is more about quality of life than length of life. Would you rather be 60 y/o and have the body and energy of a 30 y/o or be all worn out and barely able to fetch your next beer while watching TV? One thing I STRONGLY disagree with the other CR group is the philosophy that CR is not about weight loss. Weight loss helps relieve arthritis, digestive problems, heart disease, lowers cancer risk, makes your social life better in many cases, increases energy and much more. You may not live a lot longer with CR but you will be a whole lot healthier. A common error believed by many into CR is that we die of old age anyway. Factor in accidents, infectious disease, death due to lifestyle factors, genetic disorders, murder, war and more and very few of us ever die of old age. CR will not help one live to 120 y/o if a bus runs them over at age 60. Finally, animal experiments do not take stress into consideration. Many people die of stress related problems. CR is not as effective and may even be detrimental if under long term chronic stress which describes a whole lot of people. Pushing CR to the extent that one might get substantial life extension for most people causes additional stress that might well make it ineffective. I'm not talking physical stress as that may be a mechanism by which CR works. I'm talking psychological stress of years of not being able to enjoy meals with friends and family, for example. IMO for most people moderate CRON with weight loss to a low normal BMI for their frame is probably the best compromise between what CR might do and what actually will happen in their life when everything is considered. CR more intense than that is about body modification and/or a sense of adventure. I.E. it is a life style choice. Nothing wrong with this, mind you. But, let us call it what it is. NerissaAl Pater <old542000@...> wrote: Hi All,Will there be no CR in humans?See the not pdf-available Medline citation and abstract below (1).Rose, RM had previously written the below (2), with the additional reply (3).1. Phelan JP, Rose MR.Why dietary restriction substantially increases longevity in animal models but won'tin humans.Ageing Res Rev. 2005 Jul 23; [Epub ahead of print] PMID: 16046282http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=16046282 & query_hl=2... The apparent generality of the longevity-increasing effects of CR has promptedspeculation that similar results could be obtained in humans. Longevity, however, isnot a trait that exists in a vacuum; it evolves as part of a life history and thephysiological mechanisms that determine longevity are undoubtedly complex. Longevityis intertwined with reproduction and there is a cost to reproduction. The impact ofthis cost on longevity can be age-independent or age-dependent. Given the complexityof the physiology underlying reproductive costs and other mechanisms affecting lifehistory, it is difficult to construct a simple model for the relationship betweenthe particulars of the physiology involved and patterns of mortality. Consequently,we develop a hypothesis-neutral model describing the relationship between diet andlongevity. Applying this general model to the special case of human longevity anddiet indicates that the benefits of caloric restriction in humans would bequantitatively small.2. Phelan JP, Rose MR.Why dietary restriction substantially increases longevity in animal models but won'tin humans.Ageing Res Rev. 2005 Jul 23; [Epub ahead of print] PMID: 16046282... Start your day with - make it your home page Quote Link to comment Share on other sites More sharing options...
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