Eating like Buck does little for redox balance

[Guest guest]

It turns out that eating like you are a space cadet at Federation headquarters does not do as much for your "redox balance" as eating "real, whole food".

Maybe they will find the right extracts of natural foods to induce this effect, but, at the moment, taken the compounds regarded by the chemistry community (you know who I'm talking about, the Harman/ing crowd) as antioxidants does not do "that much".

It is a seperate issue of "how much" oxidative stress directly mediates aging, but I don't think you will find anyone who would contend with the notion that the capacity to handle oxidative stress is essential for "successful aging". This particular experimental model has "built-in" defects that may compromise the generalizeability of the data.

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Free Radic Biol Med. 2005 Aug 15;39(4):549-57.

Links

Effect of antioxidant-enriched diets on glutathione redox status in tissue homogenates and mitochondria of the senescence-accelerated mouse.Rebrin I, Zicker S, Wedekind KJ, Paetau- I, Packer L, Sohal RS.Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA.The main purpose of this study was to investigate whether consumption of diets enriched in antioxidants attenuates the level of oxidative stress in the senescence-accelerated mouse (SAM). In separate and independent studies, two different dietary mixtures, one enriched with vitamin E, vitamin C, L-carnitine, and lipoic acid (Diet I) and another diet including vitamins E and C and 13 additional ingredients containing micronutrients with bioflavonoids, polyphenols,

and carotenoids (Diet II), were fed for 8 and 10 months, respectively. The amounts of glutathione (GSH) and glutathione disulfides (GSSG) and GSH:GSSG ratios were determined in plasma, tissue homogenates, and mitochondria isolated from five different tissues of SAM (P8) mice. Both diets had a reductive effect in plasma; however Diet I had relatively little effect on the glutathione redox status in tissue homogenates or mitochondria. Remarkably, Diet II caused a large increase in the amount of glutathione and a marked reductive shift in glutathione redox state in mitochondria. Overall, the effects of Diet II were tissue and gender specific. Results indicated that the glutathione redox state in mitochondria and tissues can be altered by supplemental intake of a relatively complex mixture of dietary antioxidants that contains substances known to induce phase 2 enzymes, glutathione, and antioxidant defenses. Whether corresponding

attenuations occur in age-associated deleterious changes in physiological functions or life span remains unknown.PMID: 16043026 [PubMed - in process]

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=16043026

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