Mars plans Chocolate-based drugs

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FYI, Mike

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Candy good for you? Mars to probe cocoa benefits

LONDON, July 25 (Reuters) - Mars, the company that made its fortune

satisfying chocolate cravings, unveiled plans on Monday to develop

medications that use a component of cocoa to help treat diabetes,

strokes and vascular disease.

The privately held U.S. company that produces M & Ms and Mars bars

said it hoped to make medications based on flavanols -- plant

chemicals with health benefits found in cocoa, as well as red wine

and green tea.

It is now in talks with several large pharmaceutical companies for a

licensing or joint venture agreement to develop medicinal products

based on its research.

After 15 years and more than $10 million worth of studies, Mars said

it had developed hundreds of compounds that copy the aspirin-like

blood-thinning properties of cocoa flavanols.

" We know we have an interesting and powerful property that would

help people, " said Mars Chief Science Officer Dr Harold Schmitz.

" In order for these to be developed we need a big partner...It takes

not tens of million but hundreds of millions of dollars to bring a

product to market. "

He declined to say which companies Mars is in talks with.

" The mounting scientific evidence is extraordinary, " said Dr Norm

Hollenberg, Professor of Medicine at Harvard Medical School, which

has collaborated with Mars on cocoa research.

" This is a scientific breakthrough that could well lead to a medical

breakthrough. "

Hollenberg was chairing a two-day seminar with 20 science and

medical experts in Switzerland to discuss the newest research on

cocoa's potential health benefits.

Two clinical trials have found that cocoa flavanols can boost the

flow of blood to key areas of the brain, raising the possibility of

treatments for dementia and strokes.

A new clinical study has also shown flavanols' ability to improve

synthesis of nitric oxide by blood vessels could aid treatment of

blood circulation problems associated with long-term diabetes.

A medicinal drug based on Mars's research would probably use

synthetic compounds although in some areas natural cocoa compounds

had also shown to be quite promising, Schmitz said.

" Every month we are making new and different compounds, " he said.

It would take about five to seven years from agreeing a joint

venture to get a product to market, he added.

Mars has already launched CocoaVia, a nutrition bar containing 80

calories and specially preserved flavanols, which typically get

destroyed in usual cocoa processing.

The chocolate industry had to rid its products of a junk food image

and highlight cocoa's healthier qualities to encourage demand for a

produce mainly grown by poor African farmers, industry experts said

at a conference in Malaysia last week.