[Gene atm and Chronic Lymphocytic Leukemia - Review.]

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[Gene atm and Chronic Lymphocytic Leukemia - Review.]

DX Zhu, W Xu, and JY Li

Zhongguo Shi Yan Xue Ye Xue Za Zhi, October 1, 2008; 16(5): 1242-6.

Department of Hematology, The First Hospital, Nanjing Medical University;

Jiangsu Province People Hospital, Nanjing 210029, Jiangsu Province, China.

The ataxia telangiectasia mutated gene (atm) is a tumor-suppressing gene,

locates in the human chromosome 11q22-23. This gene mainly participates in

recognition and repairment of DNA damage and plays a critical role in signal

transduction pathway induced by double strand breaks (DSB). In chronic

lymphocytic leukemia (CLL) there is high frequency of loss of heterozygosity

(LOH) and mutation of atm gene, which related to pathopoiesis and progression of

CLL. This article reviewed the progress of recent studies on the characteristics

and mechanism of atm gene, as well as its role in the pathogenesis of CLL.

PMID: 18928637