Postponing human aging

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Hi All,

Prospects for postponing human aging, it seems, are fair, based on the

apparently

available and also available from our library of the below.

Rose MR, Nusbaum TJ.

Prospects for postponing human aging.

FASEB J. 1994 Sep;8(12):925-8. Review.

PMID: 8088458

The postponement of human aging is a long-standing aspiration in many cultures,

particularly non-Western ones. Renewed interest in this goal is now being shown

within the biomedical research context. This interest has probably arisen

because

several different approaches have yielded dramatic increases in mean and maximum

life span in laboratory organisms. Among the cases where aging has been

postponed in

animal models are the nematode, Caenorhabditis elegans, the common lab fruit

fly,

Drosophila melanogaster, and the dietarily restricted rodent, both Mus and

Rattus.

These successes raise the question of whether similar postponement of aging

might be

achieved in humans. Among the broad research strategies available, five can be

delineated: 1) random testing of favorite interventions; 2) searching for genes

that

can postpone aging among all or most species; 3) study of in vitro mammalian

cell

cultures; 4) study of dietarily restricted mammals; and 5) selecting mammals for

postponed aging. Although all these methods could conceivably lead to the

postponement of human aging, they are very different from each other with

respect to

their degree of uncertainty, cost, and delay.

http://www.fasebj.org/cgi/reprint/8/12/925

Al Pater, PhD; email: old542000@...

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