Mucous membrane plasmacytosis of the nose in a patient affected by B-cell chronic lymphocytic leukemia.

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Mucous membrane plasmacytosis of the nose in a patient affected by B-cell

chronic lymphocytic leukemia.

Massimiliano Garzaro, Giancarlo Pecorari, Matteo Pezzoli, Marisa Arrondini,

Domenico Novero, Juri Nadalin, and Carlo Giordano

Eur Arch Otorhinolaryngol, November 29, 2008; .

ENT Clinic, Physiopatology Department, University of Turin, Strada Val San

o Sup. 18/10, 10131, Turin, Italy, garz@....

Mucous membrane plasmacytosis (MMP) is a rare idiopathic condition characterized

by infiltration of the mucosa by non neoplastic plasma cells. In this report we

describe a case of mucous membrane plasmacytosis of the nose in a 72-year-old

woman patient affected by B-cell chronic lymphocytic leukemia (B-CLL). Two

different biopsies of the lesion showed diffuse plasma cell, lymphocyte and

granulocyte infiltration compatible with granulation tissue. A complete exeresis

of the neoplasm was performed endoscopically without complications, allowing the

diagnosis of MMP; a monthly follow up was performed with no signs of local

relapse 15 months after surgery. Topical steroid therapy with budesonide nasal

spray was administered. There is no standardized treatment for MMP: we have

reported good result of surgical approach in a unique case of nasal MMP in a

patient with B-CLL; the relation between these two diseases deserves more

studies.

PMID: 19043729