Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 We know that omega-6 fatty acids are necessary for human health, but they also increase tumor growth, once tumors have developed. Tony ========= http://www.sciencedaily.com/upi/index.php?feed=Science & article=UPI-1-20050801-21\ 063500-bc-us-omega6.xml Study: Omega-6 promotes prostate tumors SAN FRANCISCO, Aug. 1 (UPI) -- A San Francisco medical center study has demonstrated omega-6 fatty acids promote the growth of prostate tumor cells in the laboratory. The study was led by Millie -Fulford, director of the San Francisco Veterans Affairs Medical Center's Laboratory of Cell Growth, and scientific adviser to the U.S. Undersecretary of Health for the Department of Veterans Affairs. -Fulford and her team identified for the first time a direct chain of causation: When introduced into human prostate tumor cells in culture, omega-6 fatty acid causes the production of cPLA2, which then causes the production of the enzyme COX2. In turn, COX2 stimulates the release of PGE2, a hormone-like molecule that promotes cell growth. " What's important about this is that omega-6 fatty acids are found in corn oil and most of the oils used in bakery goods, " said -Fulford. " Which means that if you're eating a diet high in omega-6 fatty acids, it's possible that you're turning on this cancer cascade, which has been shown to be a common denominator in the growth of prostate, colorectal, and some breast cancers. " The study appears in the September issue of Carcinogenesis. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 Hi All, Not amega-6 fats, but only the bad one seen in red meats. See the pdf-available below. : -Fulford M, Tjandrawinata RR, Li CF, Sayyah S. Arachidonic acid, an Omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis. 2005 May 5; [Epub ahead of print] PMID: 15878913 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\ ct & list_uids=15878913 & query_hl=13 http://tinyurl.com/b4o3o --- citpeks <citpeks@...> wrote: > We know that omega-6 fatty acids are necessary for human health, but > they also increase tumor growth, once tumors have developed. > > Tony > > ========= > > http://www.sciencedaily.com/upi/index.php?feed=Science & article=UPI-1-20050801-21\ 063500-bc-us-omega6.xml > Study: Omega-6 promotes prostate tumors > > SAN FRANCISCO, Aug. 1 (UPI) -- A San Francisco medical center study > has demonstrated omega-6 fatty acids promote the growth of prostate > tumor cells in the laboratory. > > > The study was led by Millie -Fulford, director of the San > Francisco Veterans Affairs Medical Center's Laboratory of Cell Growth, > and scientific adviser to the U.S. Undersecretary of Health for the > Department of Veterans Affairs. > > -Fulford and her team identified for the first time a direct > chain of causation: When introduced into human prostate tumor cells in > culture, omega-6 fatty acid causes the production of cPLA2, which then > causes the production of the enzyme COX2. In turn, COX2 stimulates the > release of PGE2, a hormone-like molecule that promotes cell growth. > > " What's important about this is that omega-6 fatty acids are found in > corn oil and most of the oils used in bakery goods, " said > -Fulford. " Which means that if you're eating a diet high in > omega-6 fatty acids, it's possible that you're turning on this cancer > cascade, which has been shown to be a common denominator in the growth > of prostate, colorectal, and some breast cancers. " > > The study appears in the September issue of Carcinogenesis. > > > Al Pater, PhD; email: old542000@... ____________________________________________________ Start your day with - make it your home page http://www./r/hs Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 Hi All, Not amega-6 fats, but only the bad one seen in red meats. See the pdf-available below. : -Fulford M, Tjandrawinata RR, Li CF, Sayyah S. Arachidonic acid, an Omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis. 2005 May 5; [Epub ahead of print] PMID: 15878913 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\ ct & list_uids=15878913 & query_hl=13 http://tinyurl.com/b4o3o --- citpeks <citpeks@...> wrote: > We know that omega-6 fatty acids are necessary for human health, but > they also increase tumor growth, once tumors have developed. > > Tony > > ========= > > http://www.sciencedaily.com/upi/index.php?feed=Science & article=UPI-1-20050801-21\ 063500-bc-us-omega6.xml > Study: Omega-6 promotes prostate tumors > > SAN FRANCISCO, Aug. 1 (UPI) -- A San Francisco medical center study > has demonstrated omega-6 fatty acids promote the growth of prostate > tumor cells in the laboratory. > > > The study was led by Millie -Fulford, director of the San > Francisco Veterans Affairs Medical Center's Laboratory of Cell Growth, > and scientific adviser to the U.S. Undersecretary of Health for the > Department of Veterans Affairs. > > -Fulford and her team identified for the first time a direct > chain of causation: When introduced into human prostate tumor cells in > culture, omega-6 fatty acid causes the production of cPLA2, which then > causes the production of the enzyme COX2. In turn, COX2 stimulates the > release of PGE2, a hormone-like molecule that promotes cell growth. > > " What's important about this is that omega-6 fatty acids are found in > corn oil and most of the oils used in bakery goods, " said > -Fulford. " Which means that if you're eating a diet high in > omega-6 fatty acids, it's possible that you're turning on this cancer > cascade, which has been shown to be a common denominator in the growth > of prostate, colorectal, and some breast cancers. " > > The study appears in the September issue of Carcinogenesis. > > > Al Pater, PhD; email: old542000@... ____________________________________________________ Start your day with - make it your home page http://www./r/hs Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 All omegas 6s, regardless of the source, have the potential when consumed in excess total amounts and in relation to the amount of omega 3s, to " cascade " into the more harmful ones, like Arachidonic Acid, the ones found in meat. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 All omegas 6s, regardless of the source, have the potential when consumed in excess total amounts and in relation to the amount of omega 3s, to " cascade " into the more harmful ones, like Arachidonic Acid, the ones found in meat. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 I wonder about the "cascade". What do you think about the ETYA, eicosatetraynoic acid, a metabolite of AA, that limits delta 6 desaturase? Conceivably that limits EPA and AA production. As I recall the highest levels of AA in foods is fish. Beef like 0.09 gms per oz, versus canned salmon 0.17. http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=5267213 5,8,11,14-Eicosatetraynoic acid, a competitive inhibitor of arachidonic acid metabolism, rapidly and reversibly inhibited DNA synthesis in U937 cells.^ PMID: 12837767 Arachidonic acid or 5,8,11,14-eicosatetraynoic acid (ETYA), a non-metabolized analog of arachidonic acid, induced a time-dependent inhibition of Na+ transport. Regards. RE: [ ] omega-6 and tumors All omegas 6s, regardless of the source, have the potential when consumed in excess total amounts and in relation to the amount of omega 3s, to "cascade" into the more harmful ones, like Arachidonic Acid, the ones found in meat. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 I wonder about the "cascade". What do you think about the ETYA, eicosatetraynoic acid, a metabolite of AA, that limits delta 6 desaturase? Conceivably that limits EPA and AA production. As I recall the highest levels of AA in foods is fish. Beef like 0.09 gms per oz, versus canned salmon 0.17. http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=5267213 5,8,11,14-Eicosatetraynoic acid, a competitive inhibitor of arachidonic acid metabolism, rapidly and reversibly inhibited DNA synthesis in U937 cells.^ PMID: 12837767 Arachidonic acid or 5,8,11,14-eicosatetraynoic acid (ETYA), a non-metabolized analog of arachidonic acid, induced a time-dependent inhibition of Na+ transport. Regards. RE: [ ] omega-6 and tumors All omegas 6s, regardless of the source, have the potential when consumed in excess total amounts and in relation to the amount of omega 3s, to "cascade" into the more harmful ones, like Arachidonic Acid, the ones found in meat. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 >>What do you think about the ETYA, eicosatetraynoic acid, a metabolite of AA, that limits delta 6 desaturase? Conceivably that limits EPA and AA production. I agree and thats why this " ratio " between the EFAs and their metabolites and enzymes may also be important. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 >>What do you think about the ETYA, eicosatetraynoic acid, a metabolite of AA, that limits delta 6 desaturase? Conceivably that limits EPA and AA production. I agree and thats why this " ratio " between the EFAs and their metabolites and enzymes may also be important. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 The earlier article about omega-6 stimulating tumor growth probably should not be a cause of concern. Tumors have a greater growth rate than ordinary tissues. For this reason, tumors need extra nutrition, some of which will be in the form of essential fatty acids. Our concern should be to avoid tumors in the first place. Exactly how is the question. Below is an article about omega-6 to omega-3 fat ratios. Tony ==== http://www.sciencedaily.com/upi/index.php?feed=Science & article=UPI-1-20050712-10\ 565300-bc-us-boneloss.xml Essential fats might prevent bone loss WEST LAFAYETTE, Ind., July 12 (UPI) -- A recent study suggests maintaining a proper balance of dietary fats might prevent much of the bone loss associated with post-menopausal osteoporosis. Researchers at Purdue University and the Indiana University School of Medicine found diets with a low ratio of omega-6 fatty acids to omega-3 fatty acids minimized the bone loss typically brought on by estrogen deficiency, which is common in post-menopausal females. Omega-6 fatty acids are typically found in foods such as grains and beef, while omega-3 fatty acids are found in foods such as walnuts and salmon. " Our lab and others have shown that omega-3 fatty acids help promote bone formation, " said Bruce Watkins, professor and director of Purdue's Center for Enhancing Foods to Protect Health. " We also have shown that higher intakes of omega-6 fatty acids lead to an increased production of compounds associated with bone loss. " The research appears in the Journal of Nutritional Biochemistry. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2005 Report Share Posted August 2, 2005 The earlier article about omega-6 stimulating tumor growth probably should not be a cause of concern. Tumors have a greater growth rate than ordinary tissues. For this reason, tumors need extra nutrition, some of which will be in the form of essential fatty acids. Our concern should be to avoid tumors in the first place. Exactly how is the question. Below is an article about omega-6 to omega-3 fat ratios. Tony ==== http://www.sciencedaily.com/upi/index.php?feed=Science & article=UPI-1-20050712-10\ 565300-bc-us-boneloss.xml Essential fats might prevent bone loss WEST LAFAYETTE, Ind., July 12 (UPI) -- A recent study suggests maintaining a proper balance of dietary fats might prevent much of the bone loss associated with post-menopausal osteoporosis. Researchers at Purdue University and the Indiana University School of Medicine found diets with a low ratio of omega-6 fatty acids to omega-3 fatty acids minimized the bone loss typically brought on by estrogen deficiency, which is common in post-menopausal females. Omega-6 fatty acids are typically found in foods such as grains and beef, while omega-3 fatty acids are found in foods such as walnuts and salmon. " Our lab and others have shown that omega-3 fatty acids help promote bone formation, " said Bruce Watkins, professor and director of Purdue's Center for Enhancing Foods to Protect Health. " We also have shown that higher intakes of omega-6 fatty acids lead to an increased production of compounds associated with bone loss. " The research appears in the Journal of Nutritional Biochemistry. Quote Link to comment Share on other sites More sharing options...
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