Re: Re: CR reverses heart tendon glycation?

[Guest guest]

Ignoring hypergly, my take on glycation is that it is the normal thing a body does to clean up the trash as opposed to causing aging. We cycle the protein, as I recall, 500 gms per day and much is recovered.

Hypergly, OTOH, is a disease which may cause increased glycation. Another system out of control.

Regards.

----- Original Message -----

From: T

Sent: Sunday, July 24, 2005 3:14 AM

Subject: [ ] Re: CR reverses heart tendon glycation?

Heh, the THREE interesting pieces of data from this study are the following:

"Results. Mean and maximum longevities were similar in CON and TG mice....."

"In peripheral muscle, glycation and glycemic damage were generally higher in TG mice...."

"Conclusions. Lifetime overexpression of GLUT4 in muscle results in a small decrease in mean glycemia......"

Somebody help me understand this and integrate these three concepts. I sometimes need help due to the fact that my math/logic skills sometimes leave something to be desired, as I tend to work in a "inductive, subjective fuzz" that, much to the consternation of others, tends to be right with a annoyingly high frequency.

It would seem that this study confirms previous research indicating that glycemic changes have nothing to do with lifespan modifying interventions, sending this whole research front into the same conceptual rubbish heap that de Grey's tripe has already been relegated to. If one organism [ the transgenic ] is experiencing less glycemia, and yet it lives exactly the same length of time as the other *eating the same amount of food*, then we don't have a variable that is contributing to aging significantly, do we?

The only way you could argue that it still had an impact is if you suggest that the reduction in glycemia was perfectly negated by the increase in peripheral muscle glycation, but, that is a bit of stretch in my book.

I'm not saying that we shouldn't think about such influences "at all", but, in a world of stuff to worry about, I want to pick my fights intelligently and not go tilting at windmills.

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Exp Gerontol. 2005 Apr;40(4):303-14.

Related Articles,

Links

Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock.

"Taken together, these findings suggest that neither a reduction of blood glucose levels nor an increase in glucose tolerance is necessary for life span extension in mice." - PMID: 15820611 =-=-=-=-=-=-=-=-=-=

T.

pct35768@...

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