This bloke called it months ago....

[Guest guest]

I just wanted to emphasize that I do not think that everyone in the UK is clueless. This "Merry" lad from Liverpool has been saying all the right things for some time now, but some attention-phile from Cambridge tended to hog the spotlight too much. Instead of interviewing de Grey every 3 minutes, someone should have sat down with this dude for a moment and gotten the truth.

Together with his disciple Lambert, they already found what today is becoming more obvious. But, he is the first of only a handful of scientists in his "community" (which happens to exist in "Splendid Isolation") that would embrace the notion that radicals are not all they were "hyped to be".

[bollocks?]

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Mech Ageing Dev. 2005 May 11; [Epub ahead of print]

Dietary restriction in rodents-delayed or retarded ageing?Merry BJ.School of Biological

Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK."A general lack of consistency is evident in the data and this is apparent when evaluating the free radical hypothesis of ageing in this model. Further, this hypothesis as currently viewed may be too simplistic to explain the variety and complexity of the ageing phenotype. What may be more important is not oxidative macromolecular damage but the slow transition to this cellular endpoint through the slow development of oxidative stress and the role it plays in modifying cell gene expression profiles." PMID: 15893804 [PubMed - as supplied by publisher]

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J Gerontol A Biol Sci Med Sci. 2005 Feb;60(2):175-80.

Related Articles,

Links

Lack of effect of caloric restriction on bioenergetics and reactive oxygen species production in intact rat hepatocytes.Lambert AJ, Merry BJ.Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge, CB2 2XY, UK. adrian.lambert@...To investigate the hypothesis that caloric restriction alters mitochondrial function in situ, intact hepatocytes were isolated from fully fed and calorie-restricted (55% of control food intake, 4 months duration) male Brown-Norway rats at 6 months of age, and various parameters were determined. Overall, the production of reactive oxygen species was not affected by caloric restriction, neither were the mitochondrial membrane potential, oxygen consumption driving proton leak, or oxygen consumption driving ATP turnover. It is

concluded that while isolated mitochondria from liver tissue of calorie-restricted animals display a reduction in the generation of reactive oxygen species, it was not possible to confirm this effect in isolated hepatocytes. Further work is required to establish what effect, if any, caloric restriction has on the rate of generation of reactive oxygen species in intact cells and tissues and importantly at the whole-animal level.PMID: 15814858 [PubMed - indexed for MEDLINE]

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T. pct35678@...

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