CRer brain hormones

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Hi All,

Brain hormones that affect our chronobiology may play a role in CR. We tend to

sleep less on average and the urge to go out and get our daily meager food

rations

may be benefited, might it not?

See the not pdf-available below.

First, for definition, there are:

adrenocorticotropic hormone: The hormone of the anterior lobe of the hypophysis

which governs the nutrition and growth of the adrenal cortex, stimulates it to

functional activity, and also possesses extraadrenal adipokinetic activity ...

Synonym: adrenocorticotropin, adrenotropic hormone, adrenotropin, corticotropic

hormone, corticotropin.

hypophysis --> pituitary gland

adipokinetic: Denoting a substance or factor that causes mobilization of stored

lipid.

corticosterone: An adrenocortical steroid that has modest but significant

activities

as a mineralocorticoid and a glucocorticoid. Pharmacological action: steroidal

anti-inflammatory agents.

Chacon F, Esquifino AI, Perello M, Cardinali DP, Spinedi E, Alvarez MP. Related

Articles, Links

24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in

young

male rats subjected to calorie restriction.

Chronobiol Int. 2005;22(2):253-65.

PMID: 16021842

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=16021842 & query_hl=1

Calorie restriction of young male rats increases plasma prolactin, decreases

luteinizing hormone (LH) and testosterone, and disrupts their 24 h secretory

pattern. To study whether this could be the consequence of stress, we examined

the

24 h variations of plasma adrenocorticotropic hormone (ACTH) corticosterone,

growth

hormone (GH), leptin, and adrenal corticosterone. Rats were submitted to a

calorie

restriction equivalent to a 66% of usual intake for 4 weeks, starting on day 35

of

life. ... Significantly lower ACTH levels were detected in calorie-restricted

rats.

Plasma corticosterone levels during the light phase of the daily cycle were

significantly higher in calorie-restricted rats. Time-of-day variation in plasma

ACTH and corticosterone levels attained significance in calorie-restricted rats

only, with a maximum toward the end of the resting phase. The daily pattern of

adrenal gland corticosterone mirrored that of circulating corticosterone;

however,

calorie restriction reduced its levels. Plasma ACTH and corticosterone

correlated

significantly in controls only. Calorie restriction decreased plasma GH and

leptin,

and it distorted 24h rhythmicity. In a second study, plasma ACTH and

corticosterone

levels were measured in group-caged rats, isolated control rats, and

calorie-restricted rats during the light phase of the daily cycle. Plasma ACTH

of

calorie-restricted rats was lower, and plasma corticosterone was higher,

compared

with isolated or group-caged controls. The changes in the secretory pattern of

hormones hereby reported may be part of the neuroendocrine and metabolic

mechanisms

evolved to maximize survival during periods of food shortage.

Al Pater, PhD; email: old542000@...

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