Guest guest Posted January 12, 2011 Report Share Posted January 12, 2011 Dear Members, Fondaparinux is a synthetic pentasaccharide based on the structure of the antithrombin binding region of heparin. It mediates inhibition of factor Xa by antithrombin but does not cause thrombin inhibition due to its short polymer length. Fondaparinux is administered by subcutaneous injection, reaches peak plasma levels in 2 hours, and is excreted in the urine with a half-life of 17 to 21 hours. It should not be used in patients with renal failure. Because it does not interact significantly with blood cells or plasma proteins other than antithrombin, fondaparinux can be given once a day at a fixed dose without coagulation monitoring. Fondaparinux appears to be much less likely than heparin or low-molecular-weight heparin to trigger the syndrome of heparin-induced thrombocytopenia. Fondaparinux is approved for thromboprophylaxis of patients undergoing hip or knee surgery and for the therapy of pulmonary embolism and deep venous thrombosis. Regards,Dr. Vijaya Chaudhari.JR-3,Dept. of Pharmacology,Government Medical College, Nagpur. Quote Link to comment Share on other sites More sharing options...
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