Guest guest Posted January 10, 2011 Report Share Posted January 10, 2011 Dear Members, It is also important to note that the coagulation mechanism in vivo does not occur in solution, but is localized to activated cell surfaces expressing anionic phospholipids such as phosphatidylserine, and is mediated by Ca2+ bridging between the anionic phospholipids and gamma-carboxyglutamic acid residues of the clotting factors. This is the basis for using calcium chelators such as EDTA or citrate to prevent blood from clotting in a test tube. Regards,Dr. Vijaya Chaudhari.JR-3,Dept. of Pharmacology,Government Medical College, Nagpur. Quote Link to comment Share on other sites More sharing options...
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