Guest guest Posted February 22, 2011 Report Share Posted February 22, 2011 Dear members, Fixed dose combinations in India. In India a variety of combinations of drugs are available which are not included in WHOs list of essential medicine and are irrational. Following are examples of some. Pediatric formulations of Nimesulide + Paracetamol can induce severe hypothermia in small children and lead to shock. FDCs of Diclofenac + Serratiopeptidase do not offer any particular advantage over the individual drugs despite vigorous claims that Serratiopeptidase promotes more rapid resolution of inflammation. On the other hand, the patient is exposed to greater risk of gastrointestinal [GI] irritation and serious bleeding from unsuspected peptic ulceration. FDCs of quinolones and nitroimidazoles (e.g. Norfloxacin + Metronidazole, Ciprofloxacin + Tinidazole, Ofloxacin + Ornidazole) have not been recommended in any standard books, but continue to be heavily prescribed drugs in GI infections, pelvic inflammatory disease, dental infections, etc.. Such injudicious use of antibiotic FDCs can rapidly give rise to resistant strains of organisms, which is a matter of serious concern to the health care situation in our country. Regards, Dr.Sonali Pimpalkhute, Lecturer,Pharmacology. GMC,Nagpur. Quote Link to comment Share on other sites More sharing options...
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